Journal of Phytomolecules and Pharmacology, Год журнала: 2024, Номер 3(2), С. 73 - 86
Опубликована: Янв. 1, 2024
Язык: Английский
Antioxidants, Год журнала: 2025, Номер 14(1), С. 108 - 108
Опубликована: Янв. 18, 2025
The study of mitochondrial dysfunction has become increasingly pivotal in elucidating the pathophysiology various cerebral pathologies, particularly neurodegenerative disorders. Mitochondria are essential for cellular energy metabolism, regulation reactive oxygen species (ROS), calcium homeostasis, and execution apoptotic processes. Disruptions function, driven by factors such as oxidative stress, excitotoxicity, altered ion balance, lead to neuronal death contribute cognitive impairments several brain diseases. Mitochondrial can arise from genetic mutations, ischemic events, hypoxia, other environmental factors. This article highlights critical role progression diseases discusses need targeted therapeutic strategies attenuate damage, restore enhance neuroprotection.
Язык: Английский
Процитировано
1
Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13
Опубликована: Март 12, 2025
The advent of mRNA vaccines, accelerated by the global response to COVID-19 pandemic, marks a transformative shift in vaccine technology. In this article, we discuss development, current applications, and prospects vaccines for both prevention treatment infectious diseases oncology. By leveraging capacity encode antigens within host cells directly, provide versatile scalable platform suitable addressing broad spectrum pathogens tumor-specific antigens. We highlight recent advancements design, innovative delivery mechanisms, ongoing clinical trials, with particular emphasis on their efficacy combating diseases, such as COVID-19, Zika, influenza, well emerging potential cancer immunotherapy. also address critical challenges, including stability, optimization immune responses, broader issue accessibility. Finally, review strategies advancing next-generation aim overcoming limitations technology enhancing preventive therapeutic approaches oncological diseases.
Язык: Английский
Процитировано
1
Frontiers in Medicine, Год журнала: 2025, Номер 12
Опубликована: Янв. 21, 2025
Knee osteoarthritis (OA) is a common condition that causes pain and reduces the quality of life for many people. It also leads to high health financial costs. Managing knee OA requires using different methods together best results. This review overviews current therapeutic options pain, focusing on their efficacy, safety, potential roles in clinical practice. Topical treatments, such as NSAIDs capsaicin, offer significant relief with minimal systemic side effects are suitable initial therapy, nonpharmacologic interventions like exercise and, when relevant, weight loss. Oral analgesics, including acetaminophen opioids, have limited efficacy serious effects, making them appropriate only short-term or rescue therapy. Intra-articular injections, corticosteroids, hyaluronic acid, platelet rich plasma, demonstrate varying levels safety. Nutritional supplements, curcumin, Boswellia serrata , glucosaminechondroitin combinations, modest benefits used adjuncts standart treatment. Nonpharmacological transcutaneous electrical nerve stimulation (TENS), acupuncture, local heat provide variable should be customized based individual patient responses. Targeted biologic agents, antibodies TNF-α, IL-1, NGF, hold promise more precise relief; however, further research required establish routine use. Treating personalized, combining several methods. Research must continue improve treatments make safer.
Язык: Английский
Процитировано
0
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Март 19, 2025
Background Osteoarthritis (OA) and impaired glucose tolerance (IGT) frequently coexist, leading to compounded clinical metabolic challenges. This study investigates the effects of metformin in improving both outcomes (pain, stiffness, physical function) parameters (inflammatory markers, lipid profile, BMI) patients with knee OA IGT. Methods The included 60 diagnosed Participants were divided into two groups: 26 received standard treatment without (Without Metf), while 34 (500 mg twice daily) for 3 months, addition (With Metf). Clinical assessments (WOMAC, Lequesne Algofunctional Index, KOOS, VAS) markers (CRP, NLR, SOD, measured before treatment, after 1 month, months. Results With Metf group showed significantly greater improvements pain, function, quality life compared Without group. Metformin also led significant reductions inflammatory profiles health indicators. demonstrated enhanced BMI, waist-to-hip ratio, waist-to-height ratio. Furthermore, need increased NSAID doses was predicted by factors such as pain severity markers. Conclusion effectively alleviates osteoarthritis symptoms improves Further research is needed explore its long-term on joint health, potential role management
Язык: Английский
Процитировано
0
Journal of King Saud University - Science, Год журнала: 2025, Номер 37, С. 1032024 - 1032024
Опубликована: Март 22, 2025
Язык: Английский
Процитировано
0
Cells, Год журнала: 2025, Номер 14(7), С. 519 - 519
Опубликована: Март 31, 2025
Small extracellular vesicles (sEVs) derived from different osteoarthritic (OA) tissues regulate OA-related biological processes through transporting their content (proteins, miRNAs, etc.) to recipient cells. This study aimed characterize the miRNA profile of synovial fibroblasts-derived small EVs (FS_OA_sEVs) and investigate role in inflammation chondrocytes. Chondrocytes were isolated macroscopically preserved lesioned OA cartilage (C_OAmin C_OAmax) fibroblasts synovium. Synovial characterized according ISEV guidelines used for profiling bioinformatics analysis. miR-21-5p was identified as one most abundant, its target genes, such KLF6, enriched including inflammation. Treatment C_OAmin chondrocytes with FS_OA_sEVs resulted decreased expression COL2A1 ACAN an increase catabolic markers MMP-3 MMP-13. Moreover, C-OAmin receiving exhibited increased levels inflammatory expression, resembling chondrocytes’ phenotype cartilage, whereas inhibition reversed miR-21-5p. Compared C_OA min, C_OAmax KLF6 expression. led upregulation suppression mediators, co-treatment siRNA against negated this effect, confirming a potential direct regulatory relationship between KLF6. Our results provide novel insights into FS_OA_sEV-mediated axis, highlighting FS_OA_sEV-derived driver progression via regulating
Язык: Английский
Процитировано
0
Egyptian Journal of Basic and Applied Sciences, Год журнала: 2025, Номер 12(1), С. 220 - 236
Опубликована: Апрель 14, 2025
Язык: Английский
Процитировано
0
Journal of Personalized Medicine, Год журнала: 2025, Номер 15(4), С. 156 - 156
Опубликована: Апрель 17, 2025
Background: This study investigated the role of genetic polymorphisms in IFNAR2, OAS1, OAS3, and ACE2 as predictors Paxlovid treatment response, specifically examining their influence on clinical course laboratory parameters COVID-19 patients. Methods: We analyzed impact genes associated with interferon pathway (IFNAR2 rs2236757), antiviral response (OAS1 rs10774671, OAS3 rs10735079), viral entry (ACE2 rs2074192) individuals treated Paxlovid. Results: Our findings suggest that variations these may modulate immune coagulation pathways context during infection. Specifically, IFNAR2 rs2236757 G allele was alterations inflammatory markers, while OAS1 influenced parameters. Furthermore, specific genotypes were linked to changes such oxygen saturation, leukocyte count, liver function markers Paxlovid-treated Conclusions: These results highlight potential considering factors understanding individual responses informing future personalized approaches.
Язык: Английский
Процитировано
0
Viruses, Год журнала: 2024, Номер 16(12), С. 1938 - 1938
Опубликована: Дек. 18, 2024
Metformin, a widely used antidiabetic medication, has emerged as promising broad-spectrum antiviral agent due to its ability modulate cellular pathways essential for viral replication. By activating AMPK, metformin depletes energy reserves that viruses rely on, effectively limiting the replication of pathogens such influenza, HIV, SARS-CoV-2, HBV, and HCV. Its role in inhibiting mTOR pathway, crucial protein synthesis reactivation, is particularly significant managing infections caused by CMV, EBV. Furthermore, reduces oxidative stress reactive oxygen species (ROS), which are critical replicating arboviruses Zika dengue. The drug also regulates immune responses, differentiation, inflammation, disrupting life cycle HPV potentially other viruses. These diverse mechanisms suppress replication, enhance system functionality, contribute better clinical outcomes. This multifaceted approach highlights metformin’s potential an adjunctive therapy treating wide range infections.
Язык: Английский
Процитировано
1
Journal of Phytomolecules and Pharmacology, Год журнала: 2024, Номер 3(2), С. 73 - 86
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0