The gut microbiota-inflammation-HFpEF axis: deciphering the role of gut microbiota dysregulation in the pathogenesis and management of HFpEF

Frontiers in Cellular and Infection Microbiology, Год журнала: 2025, Номер 15

Опубликована: Март 13, 2025

Heart failure with preserved left ventricular ejection fraction (HFpEF) is a disease that affects multiple organs throughout the body, accounting for over 50% of heart cases. HFpEF has significant impact on individuals’ life expectancy and quality life, but exact pathogenesis remains unclear. Emerging evidence implicates low-grade systemic inflammation as crucial role in onset progression HFpEF. Gut microbiota dysregulation associated metabolites alteration, including short-chain fatty acids, trimethylamine N-oxides, amino bile acids can exacerbate chronic inflammatory responses potentially contribute to In light these findings, we propose hypothesis “gut microbiota-inflammation-HFpEF axis”, positing interplay within this axis could be factor development This review focuses gut dysregulation-induced HFpEF’s etiology. It explores potential mechanisms linking cardiac dysfunction evaluates therapeutic restoring balance mitigating severity. The objective offer novel insights strategies management

Язык: Английский

Molecular and Cellular Mechanisms of Immunosenescence: Modulation Through Interventions and Lifestyle Changes

Biology, Год журнала: 2024, Номер 14(1), С. 17 - 17

Опубликована: Дек. 27, 2024

Immunosenescence, the age-related decline in immune function, is a complex biological process with profound implications for health and longevity. This phenomenon, characterized by alterations both innate adaptive immunity, increases susceptibility to infections, reduces vaccine efficacy, contributes development of diseases. At cellular level, immunosenescence manifests as decreased production naive T B cells, accumulation memory senescent thymic involution, dysregulated cytokine production. Recent advances molecular biology have shed light on underlying mechanisms immunosenescence, including telomere attrition, epigenetic alterations, mitochondrial dysfunction, changes key signaling pathways such NF-κB mTOR. These lead functional impairments various cell types, altering their proliferative capacity, differentiation, effector functions. Emerging research suggests that lifestyle factors may modulate rate extent at levels. Physical activity, nutrition, stress management, sleep patterns been shown influence inflammatory markers, oxidative older adults. review provides comprehensive analysis explores how interventions impact these processes. We will examine current understanding genomic, epigenomic, proteomic levels, discuss can potentially mitigate or partially reverse aspects aging. By integrating recent findings from immunology, gerontology, biology, we aim elucidate intricate interplay between aging informing future strategies maintaining competence populations.

Язык: Английский