Applications of polymeric nanoparticles in drug delivery for glioblastoma
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 6, 2025
Glioblastoma
(GBM)
remains
one
of
the
most
aggressive
and
treatment-resistant
brain
tumors,
necessitating
innovative
therapeutic
approaches.
Polymer-based
nanotechnology
has
emerged
as
a
promising
solution,
offering
precise
drug
delivery,
enhanced
blood-brain
barrier
(BBB)
penetration,
adaptability
to
tumor
microenvironment
(TME).
This
review
explores
diverse
applications
polymeric
nanoparticles
(NPs)
in
GBM
treatment,
including
delivery
chemotherapeutics,
targeted
therapeutics,
immunotherapeutics,
other
agents
for
radiosensitization
photodynamic
therapy.
Recent
advances
multifunctional
polymer
highlight
their
potential
overcome
challenges
that
brought,
such
heterogeneity
tumor,
BBB
limitation,
immunosuppressive
TME,
consideration
biocompatibility
safety.
Meanwhile,
future
directions
address
these
are
also
proposed.
By
addressing
obstacles,
polymer-based
represents
transformative
strategy
improving
treatment
outcomes,
paving
way
more
effective
patient-specific
therapies.
Язык: Английский
Progress in Drug Delivery Systems Based on Nanoparticles for Improved Glioblastoma Therapy: Addressing Challenges and Investigating Opportunities
Cancers,
Год журнала:
2025,
Номер
17(4), С. 701 - 701
Опубликована: Фев. 19, 2025
Glioblastoma
multiforme
(GBM)
is
a
highly
malignant
brain
tumor
that
has
bleak
outlook
despite
existing
treatments
such
as
surgery,
radiation,
and
chemotherapy.
The
utilization
of
nanoparticles
for
drug
delivery
presents
promising
method
by
which
to
improve
the
effectiveness
treatment
while
reducing
harmful
effects
on
entire
body.
This
review
examines
application
in
GBM,
focusing
different
types
nanoparticles,
including
lipid-based,
polymeric,
metallic,
those
under
development.
Every
variety
analyzed
its
distinct
characteristics
therapeutic
capacity.
Lipid-based
liposomes
solid
lipid
enhance
transport
medicines
are
not
soluble
water
have
shown
considerable
potential
preclinical
investigations.
Polymeric
benefits
terms
controlled
release
targeted
distribution,
whereas
metallic
both
therapy
imaging.
In
current
we
would
like
emphasize
ways
medicine
delivery,
specifically
enhancing
penetration
blood-brain
barrier
(BBB),
targeting
tumors,
enabling
release.
Additionally,
also
discuss
clinical
discoveries,
highlighting
achievements
obstacles
process
converting
these
technologies
into
effective
GBM.
study
offers
thorough
examination
present
status
prospects
Язык: Английский
A Comprehensive review on exploring Thymoquinone as novel therapeutic molecule for clinical management of Glioblastoma Multiforme
Pharmacological Research - Natural Products,
Год журнала:
2024,
Номер
unknown, С. 100107 - 100107
Опубликована: Окт. 1, 2024
Язык: Английский
Nanoparticle-Based Approaches in the Diagnosis and Treatment of Brain Tumors
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(23), С. 7449 - 7449
Опубликована: Дек. 6, 2024
Glioblastomas
are
highly
invasive
brain
tumors
among
perilous
diseases.
They
characterized
by
their
fast
proliferation
and
delayed
detection
that
render
them
a
significant
focal
point
for
medical
research
endeavors
within
the
realm
of
cancer.
Among
glioblastomas,
Язык: Английский
Advances in Nanotheranostic Systems for Concurrent Cancer Imaging and Therapy: An Overview of the Last 5 Years
Molecules,
Год журнала:
2024,
Номер
29(24), С. 5985 - 5985
Опубликована: Дек. 19, 2024
The
rapid
development
of
nanotechnology
during
the
last
two
decades
has
created
new
opportunities
to
design
and
generate
more
advanced
nanotheranostics
with
diversified
capabilities
for
diagnosis,
drug
delivery,
treatment
response
monitoring
in
a
single
platform.
To
date,
several
approaches
have
been
employed
order
develop
nanotheranostics.
purpose
this
review
is
briefly
discuss
key
components
nanotheranostic
systems,
present
conventional
upcoming
imaging
therapeutic
modalities
that
employ
evaluate
recent
progress
field
cancer
systems
past
five
years
(2020–2024).
Special
attention
focused
on
their
composition,
specificity,
potential
multimodal
therapy,
vitro
vivo
characterization.
Язык: Английский