Advances in Materials Science for Precision Melanoma Therapy: Nanotechnology-Enhanced Drug Delivery Systems
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 296 - 296
Опубликована: Фев. 24, 2025
Melanoma,
a
highly
aggressive
form
of
skin
cancer,
poses
major
therapeutic
challenge
due
to
its
metastatic
potential,
resistance
conventional
therapies,
and
the
complexity
tumor
microenvironment
(TME).
Materials
science
nanotechnology
advances
have
led
using
nanocarriers
such
as
liposomes,
dendrimers,
polymeric
nanoparticles,
metallic
nanoparticles
transformative
solutions
for
precision
melanoma
therapy.
This
review
summarizes
findings
from
Web
Science,
PubMed,
EMBASE,
Scopus,
Google
Scholar
highlights
role
in
overcoming
treatment
barriers.
Nanoparticles
facilitate
passive
active
targeting
through
mechanisms
enhanced
permeability
retention
(EPR)
effect
functionalization
with
tumor-specific
ligands,
thereby
improving
accuracy
drug
delivery
reducing
systemic
toxicity.
Stimuli-responsive
systems
multi-stage
further
improve
overcome
challenges
poor
penetration
resistance.
Emerging
platforms
combine
diagnostic
imaging
delivery,
paving
way
personalized
medicine.
However,
there
are
still
issues
scalability,
biocompatibility,
regulatory
compliance.
comprehensive
potential
integrating
genetics
proteomics,
scalable,
patient-specific
therapies.
These
interdisciplinary
innovations
promise
redefine
provide
safer,
more
effective,
accessible
treatments.
Continued
research
is
essential
bridge
gap
between
evidence-based
scientific
clinical
applications.
Язык: Английский
Analysis of IL10 gene promoter haplotypes and changes in mRNA expression and soluble levels in patients with basal cell carcinoma
Archives of Dermatological Research,
Год журнала:
2025,
Номер
317(1)
Опубликована: Янв. 18, 2025
Язык: Английский
Phytoflavonoids as alternative therapeutic effect for melanoma: Integrative Network pharmacology, molecular dynamics and drug-likeness profiling for lead discovery
Computational Biology and Chemistry,
Год журнала:
2025,
Номер
117, С. 108390 - 108390
Опубликована: Фев. 22, 2025
Язык: Английский
Harnessing Folate Receptors: A Comprehensive Review on the Applications of Folate-Adorned Nanocarriers for the Management of Melanoma
Prajakta Sahane,
Niharika Puri,
Pooja Khairnar
и другие.
ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 24, 2025
The
advancement
in
exclusively
tailored
therapeutic
delivery
systems
has
escalated
a
great
deal
of
interest
targeted
to
augment
efficacy
and
lessen
adverse
effects.
approach
promisingly
helps
surmount
the
unmet
clinical
needs
conventional
therapies,
including
chemoresistance,
limited
penetration,
side
In
case
melanoma,
various
receptors
were
overexpressed
on
tumor
site,
among
which
folate
receptor
(FR)
targeting
is
considered
be
progressive
for
managing
melanoma.
FRs
are
macromolecules
glycosyl
phosphatidylinositol-attached
protein
that
possess
globular
assembly
with
greater
affinity
toward
specific
ligands.
So,
functional
ligands
can
utilized
design
nanocarriers
(NCs)
effectively
bind
FRs.
Hence,
folate-adorned
NCs
(FNCs)
offer
benefits
such
as
site-specific
targeting,
cargo
protection,
minimizing
toxicity.
This
review
focuses
insights
implications
FRs,
mechanisms,
challenges,
advantages
FNCs.
Further,
applications
FNCs,
liposomes,
polymeric
NCs,
albumin
nanoparticles,
inorganic
liquid
crystalline
nanogels,
have
been
elaborated
melanoma
therapy.
Likewise,
potential
FNCs
immunotherapy,
photodynamic
therapy,
chemotherapy,
gene
photothermal
imaging
exhaustively
discussed.
Furthermore,
translational
hurdles
solutions
discussed
detail.
present
expected
give
thoughtful
ideas
researchers,
industry
stakeholders,
formulation
scientists
efficacious
development
Язык: Английский
A comprehensive review of PRAME and BAP1 in melanoma: Genomic instability and immunotherapy targets
Cellular Signalling,
Год журнала:
2024,
Номер
unknown, С. 111434 - 111434
Опубликована: Сен. 1, 2024
Язык: Английский
Characterizing CD133 and NANOG Expression in Melanoma: Associations with Histological and Epidemiological Parameters
Medicina,
Год журнала:
2024,
Номер
60(10), С. 1658 - 1658
Опубликована: Окт. 10, 2024
:
Melanoma
is
an
aggressive
skin
malignancy,
and
the
majority
of
deaths
associated
with
melanoma
result
from
malignant
lesions.
Our
study
aims
to
evaluate
expression
markers
CD133
NANOG,
tumor
stem
cells,
analyze
their
link
epidemiological
histological
parameters,
thus
contributing
early
diagnosis
development
targeted
therapies.
Язык: Английский
The roles of cancer stem cells and therapeutic implications in melanoma
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 14, 2024
Melanoma
is
a
highly
malignant
skin
tumor
characterized
by
high
metastasis
and
poor
prognosis.
Recent
studies
have
highlighted
the
pivotal
role
of
melanoma
stem
cells
(MSCs)-a
subpopulation
cancer
(CSCs)-in
driving
growth,
metastasis,
therapeutic
resistance,
recurrence.
Similar
to
CSCs
in
other
cancers,
MSCs
possess
unique
characteristics,
including
specific
surface
markers,
dysregulated
signaling
pathways,
ability
thrive
within
complex
microenvironment
(TME).
This
review
explored
current
landscape
MSC
research,
discussing
identification
MSC-specific
key
pathways
such
as
Wnt/β-catenin,
Notch,
Hedgehog
(Hh),
how
interactions
TME,
hypoxia
immune
cells,
contribute
MSC-mediated
drug
resistance
metastatic
behavior.
Furthermore,
we
also
investigated
latest
strategies
targeting
MSCs,
small-molecule
inhibitors,
immune-based
approaches,
novel
vaccine
developments,
with
an
emphasis
on
their
potential
overcome
progression
improve
clinical
outcomes.
aims
provide
valuable
insights
into
roles
biology
offers
perspectives
for
future
research
advances
against
this
challenging
disease.
Язык: Английский