Supplementary Treatment for Alleviating Pain and Enhancing Functional Ability in Geriatric Patients with Osteoarthritis
Healthcare,
Год журнала:
2025,
Номер
13(2), С. 127 - 127
Опубликована: Янв. 11, 2025
Background
and
Objectives:
A
degenerative
joint
disease
that
primarily
affects
elderly
individuals,
osteoarthritis
(OA)
causes
pain,
decreased
mobility,
a
lower
quality
of
life.
Procaine
is
regarded
as
“veteran”
medicine
due
to
its
extensive
clinical
use,
although
it
remains
molecule
interest,
researchers
are
uncovering
new
biological
pharmacological
effects
through
innovative
experimental
methods.
This
study
evaluates
the
efficacy
“procaine
complex”,
developed
in
our
country,
alleviating
pain
improving
functionality
individuals
with
knee
hip.
Materials
Methods:
We
conducted
an
assessment
longitudinal
short-term
involving
177
patients
aged
65
older,
who
were
randomly
divided
into
two
groups.
One
group
received
physical
therapy
complex”
periarticular
injections
(n
=
101),
while
other
just
76).
assessed
using
visual
analog
scale
(VAS),
addition
functional
evaluations
Lequesne
Index,
Activities
Daily
Living
(ADL),
Instrumental
ADL
(IADL)
scores.
evaluated
these
CGA
(complex
geriatric
assessment),
walk
test,
“Up
Go”
Mini
Mental
State
(MMSE)
Geriatric
Depression
Scale
(GDS)
for
cognitive
status.
analyzed
all
data
from
this
PSPP
v3
software.
Results:
The
procaine
complex
treatment
exhibited
significant
reduction
(p
<
0.001)
improvement
daily
activities
relative
control
group.
However,
there
was
no
notable
difference
walking
test
scores
0.171).
No
substantial
detrimental
identified.
did
not
surpass
reducing
depressive
disorders,
but
both
groups
showed
some
enhancement
regard.
Conclusions:
demonstrates
approach
management
by
integrating
therapy.
provides
experiencing
limitations
secure
efficacious
alternative
surgery,
or
may
diminish
years
disability.
Язык: Английский
Rheumatoid Arthritis and COVID-19 at the Intersection of Immunology and Infectious Diseases: A Related PRISMA Systematic Literature Review
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(20), С. 11149 - 11149
Опубликована: Окт. 17, 2024
Rheumatoid
arthritis
(RA)
patients
face
different
health
challenges
when
infected
with
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
than
the
general
population,
due
to
both
their
immunocompromised
state
and
immunosuppressive
therapies
they
receive.
This
systematic
literature
review,
which
follows
Preferred
Reporting
Items
for
Systematic
Reviews
Meta-Analyses
(PRISMA)
paradigm,
explores
interactions
between
RA
SARS-CoV-2
infection,
focusing
on
immunologic
issues,
disease
management,
vaccination,
adverse
outcomes.
In
order
obtain
most
relevant
information,
we
systematically
reviewed
specific
from
1
January
2021
31
December
2023,
based
PRISMA
method,
by
eventually
selected
35
eligible
articles,
added
other
ISI-indexed
studies
enrich
our
results
further.
Consequently,
performed
a
funnel
analysis
evaluate
potential
publication
bias.
Firstly,
data
collected
revealed
impact
of
pandemic
diagnoses
fear
face-to-face
medical
consultations
that
delayed
adequate
treatment.
Secondly,
cardiovascular
metabolic
comorbidities
increase
risk
prolonged
COVID-19
symptoms,
hospitalization,
outcomes
patients.
With
respect
treatment
used
control
RA,
it
was
observed
glucocorticoids
(especially
high-dose
usage)
Rituximab
(RTX)
predispose
poor
outcomes,
as
opposed
Baricitinib
interleukin-6
(IL-6)
tumor
necrosis
factor-alpha
(TNF-α)
inhibitors.
vaccination
has
proven
effective
generally
safe
in
some
studies,
although
Methotrexate
(MTX),
Abatacept
(ABA),
RTX
have
been
associated
impaired
vaccine
immune
response.
review
brings
updated
thorough
information
immunological,
clinical,
management
complex
immune-mediated
inflammatory
(IMID)
like
setting
underlines
faced
this
group
The
lessons
learned
can
be
extended
beyond
shaping
more
informed
compassionate
healthcare
system
offering
long-term
care
RA.
Язык: Английский
Predictive Factors for COVID-19 Severity in Patients with Axial Spondyloarthritis: Real-World Data from the Romanian Registry of Rheumatic Diseases
Medicina,
Год журнала:
2025,
Номер
61(3), С. 411 - 411
Опубликована: Фев. 26, 2025
Background
and
Objectives:
Coronavirus
disease-2019
(COVID-19)
posed
unique
challenges
worldwide,
underscoring
important
gaps
in
healthcare
preparedness
for
patients
receiving
immunosuppressive
therapies,
such
as
the
individuals
with
axial
spondyloarthritis
(axSpA),
a
subgroup
of
(SpA)
characterized
by
chronic
inflammation
immune
dysregulation.
While
global
registry
data
exist
SpA,
specific
on
axSpA
alone
remain
scarce,
especially
Central
Eastern
European
populations.
This
study
aims
to
identify
predictive
factors
severe
COVID-19
outcomes
provide
descriptive
analysis
infected
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2),
using
real-world
from
Romanian
Registry
Rheumatic
Diseases
(RRBR).
Materials
Methods:
is
three-year
retrospective
observational
cohort
that
included
5.786
RRBR,
whom
183
(3.16%)
were
diagnosed
SARS-CoV-2
infection.
Data
analyzed
R
V4.4.1
performing
univariate
multivariate
binary
logistic
regression
estimate
associations
odds
ratios
(ORs),
95%
confidence
intervals
(CIs),
p-values.
A
backward
selection
algorithm
was
applied
create
final
model,
accounting
multicollinearity
through
variance
inflation
(VIFs).
Results:
The
mean
age
48.19
±
12.26
years,
male
predominance
(64.5%).
Serious
(encompassing
moderate
critical
cases)
occurred
46
cases,
≥
52.5
years
(OR
2.64,
CI:
1.28–5.48,
p
=
0.009)
arterial
hypertension
2.57,
1.29–5.16,
0.007)
identified
significant
predictors.
Individuals
advanced
education
levels
had
nearly
three
times
lower
experiencing
serious
0.38,
0.18–0.76,
0.008).
Furthermore,
our
findings
confirm
lack
association
between
HLA-B27
severity
(p
0.194),
contributing
ongoing
discussion
regarding
its
potential
immunological
role.
Moreover,
irrespective
biological
therapy
administered,
likelihood
not
statistically
0.882).
In
only
older
higher
deemed
factors.
Conclusions:
highlights
key
predictors
emphasizes
protective
role
education,
an
underexplored
determinant
health
inflammatory
diseases.
lessons
learned
during
these
last
can
shape
more
informed
compassionate
system.
Язык: Английский
Gynecological Insights into Lynch Syndrome—A Comprehensive Review of Cancer Screening and Prevention
Medicina,
Год журнала:
2024,
Номер
60(12), С. 2013 - 2013
Опубликована: Дек. 6, 2024
Lynch
syndrome,
one
of
the
most
common
genetic
syndromes
predisposing
to
cancer,
is
associated
with
a
series
malignant
conditions,
among
which
frequent
colorectal
but
gynecologic
cancers
(especially
endometrial)
are
also
quite
common.
Despite
significant
progress
made
in
understanding
this
condition
over
time,
there
still
aspects
managing
that
have
not
demonstrated
clear
benefits.
This
article
aims
summarize
recommendations
international
societies
and
present
latest
developments
focusing
on
cancer
screening
possible
prevention
strategies.
Advances
testing
procedures
discoveries
related
association
between
oncological
pathology
frequency
affected
pathogenic
variant
type
will
probably
lead
personalized
medicine
focused
individual
patient
coming
years.
Although
various
methods
for
gynecological
patients
syndrome
been
used
they
shown
survival
highlights
need
studying
implementing
new
diagnostic
methods,
under
investigation
recent
years
mentioned
article.
Язык: Английский