Simulating Arterial Stress for Rapid Evaluation of Antivascular Calcification Therapies from Herbal Extracts DOI
Yu Pan, Yuhang Zhang,

Junsheng Lin

и другие.

ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Янв. 24, 2025

Vascular calcification severely disrupts cardiovascular hemodynamics, leading to high rates of morbidity and mortality. Despite their clinical impact, the development effective treatments remains limited, underscoring an urgent need for efficient reliable drug screening methods. smooth muscle cells (VSMCs) are known play a central role in driving process, undergoing osteogenic transition response pathological conditions. To mimic this we developed cyclic stretching device that replicates physiological mechanical stresses experienced by VSMCs during arterial pulsation. This dramatically accelerates VSMCs, reducing phenotypic switching from 13 days under static conditions just 4 h. Using device, screened 20 herbal extracts anticalcification properties identifiedSalvia miltiorrhizaas candidate with therapeutic potential inhibits VSMC transdifferentiation vitro. The efficacy ofSalvia miltiorrhizawas further validated vitamin D-induced rat model calcification, highlighting its translational potential. platform provides rapid physiologically relevant method evaluating antivascular therapies, significantly improving efficiency discovery translation.

Язык: Английский

Aging-related hyperphosphatemia triggers the release of TNF-α from macrophages, promoting indicators of sarcopenia through the reduction of IL-15 expression in skeletal muscle DOI Creative Commons
Elena Alcalde‐Estévez,

Ariadna Moreno-Piedra,

Ana Asenjo‐Bueno

и другие.

Life Sciences, Год журнала: 2025, Номер 368, С. 123507 - 123507

Опубликована: Фев. 25, 2025

Язык: Английский

Процитировано

1
Simulating Arterial Stress for Rapid Evaluation of Antivascular Calcification Therapies from Herbal Extracts DOI
Yu Pan, Yuhang Zhang,

Junsheng Lin

и другие.

ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Янв. 24, 2025

Vascular calcification severely disrupts cardiovascular hemodynamics, leading to high rates of morbidity and mortality. Despite their clinical impact, the development effective treatments remains limited, underscoring an urgent need for efficient reliable drug screening methods. smooth muscle cells (VSMCs) are known play a central role in driving process, undergoing osteogenic transition response pathological conditions. To mimic this we developed cyclic stretching device that replicates physiological mechanical stresses experienced by VSMCs during arterial pulsation. This dramatically accelerates VSMCs, reducing phenotypic switching from 13 days under static conditions just 4 h. Using device, screened 20 herbal extracts anticalcification properties identifiedSalvia miltiorrhizaas candidate with therapeutic potential inhibits VSMC transdifferentiation vitro. The efficacy ofSalvia miltiorrhizawas further validated vitamin D-induced rat model calcification, highlighting its translational potential. platform provides rapid physiologically relevant method evaluating antivascular therapies, significantly improving efficiency discovery translation.

Язык: Английский

Процитировано

0