Alterations in the inflammatory homeostasis of aging‐related cardiac dysfunction and Alzheimer's diseases

The FASEB Journal, Год журнала: 2025, Номер 39(1)

Опубликована: Янв. 6, 2025

Alzheimer's disease (AD) is well known among the elderly and has a profound impact on both patients their families. Increasing research indicates that AD systemic disease, with strong connection to cardiovascular disease. They share common genetic factors, such as mutations in presenilin (PS1 PS2) apolipoprotein E (APOE) genes. Cardiovascular conditions can lead reduced cerebral blood flow increased oxidative stress. These factors contribute accumulation of Aβ plaques formation abnormal tau protein tangles, which are key pathological features AD. Additionally, deposits responses have been observed cardiomyocytes peripheral tissues. The toxic deposition intensifies damage microvascular structure associated blood-brain barrier disruption initiation neuroinflammation, may accelerate onset neurocognitive deficits dysfunction. Thus, we discuss main mechanisms linking cardiac dysfunction enhance our understanding these conditions. Ultimately, insights into brain-heart axis help us develop effective treatment strategies future.

Язык: Английский

---

Cardiac biomarkers as predictors of cognitive decline in neurodegenerative conditions

Progress in brain research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

---

Metabolomic and transcriptomic features of the cardiometabolic disease spectrum in people living with HIV

Infectious Diseases & Immunity, Год журнала: 2025, Номер unknown

Опубликована: Апрель 25, 2025

Abstract Background: Human immunodeficiency virus (HIV) infection is associated with significant metabolic disruptions, and understanding how these disruptions contribute to cardiovascular disease (CVD) essential for improving patient management therapeutic strategies. By integrating metabolomics transcriptomics, we aimed elucidate the cardiometabolic spectrum of people living HIV (PLWH) identify biomarkers pathways progression in this population. Methods: We conducted a cross-sectional observational study between October 2022 June 2023 at Third People’s Hospital Shenzhen, China. Participants were categorized into one four groups: HIV+ without abnormalities (healthy control [HC]), + untreated (UM) (HIV UM), treated (TM) TM), CVD CVD). Key transcriptomic features identified through comparative analysis using untargeted RNA sequencing, followed by statistical pathway enrichment analyses. Results: This included 114 PLWH: HC group ( n = 30), UM 19), TM 46), 19). Through analyses metabolomic data across groups, 580 dysmetabolic (DMFs) based on changes UM/TM no statistically differences vs. comparisons. Notably, 90.52% DMFs (525/580) exhibited reduced abundance group. In contrast, 241 CVD-specific groups. These features, primarily found group, metabolites genes strongly chronic inflammation endothelial dysfunction—key processes pathogenesis among PLWH. Features that indicated transition from termed escalation (ESCFs). ESCFs early lipid dysregulation, such as phosphatidylcholine (O-22:1/20:4), upregulated genes, CAMP , both which showed progressive groups reversal expression trends—such those increasing but decreasing or vice versa—were de-escalation (DSCFs). DSCFs species involved metabolism mitochondrial function. The integration revealed pathways, glycerophospholipid arachidonic acid metabolism, concurrent upregulation cholesterol biosynthesis immune response. Receiver operating characteristic curve markedly improved prediction PLWH, an area under 0.965, sensitivity 84.2%, specificity 96.9%. Conclusions: key alterations alterations, driven activation, inflammation, reflect unique molecular characteristics Our findings underscore importance detection tailored interventions manage risk population, providing insights potential progression.

Язык: Английский

---

Dysregulation of synaptic-related genes of neuroimmune networks within peripheral blood mononuclear cells in major depressive disorder

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 14, 2024

ABSTRACT Major depressive disorder (MDD) involves complex neuroimmune interactions linked to gene modulation. Our study investigates synaptic-related dysregulation in peripheral blood mononuclear cells (PBMCs) from MDD patients, showing how these immune mirror neural processes. Using RNA-seq data, we identified 1,383 differentially expressed genes (DEGs) related crosstalk, with 49 DEGs effectively distinguishing patients controls based on synaptic functions. Synaptic genes, enriched for roles like vesicle transport, suggest mechanistic links between and signaling. Eleven were shared PBMCs brain regions involved mood regulation, highlighting a common molecular signature. Among them, ADORA3 RPS28 emerged as potential biomarkers. These findings highlight the of diagnosis treatment MDD, reinforcing development future neuroimmune-targeted therapies depression.

Язык: Английский

---

Targeting the Ca2+ signaling toolkit as an alternative strategy to mitigate SARS-CoV-2-induced cardiovascular adverse events

Vascular Pharmacology, Год журнала: 2024, Номер unknown, С. 107458 - 107458

Опубликована: Дек. 1, 2024

Язык: Английский

---