Immune Cell Interplay in the Fight Against GBM
Cancers,
Год журнала:
2025,
Номер
17(5), С. 817 - 817
Опубликована: Фев. 26, 2025
Despite
multimodal
therapies,
the
treatment
of
glioblastoma
remains
challenging.
In
addition
to
very
complex
mechanisms
cancer
cells,
including
specialized
phenotypes
that
enable
them
proliferate,
invade
tissues,
and
evade
immunosurveillance,
they
exhibit
a
pronounced
resistance
chemo-
radiotherapy.
More
advanced
tumors
create
hypoxic
environment
supports
their
proliferation
survival,
while
robust
angiogenesis
ensures
constant
supply
nutrients.
GBM,
these
structures
are
contribute
creation
maintenance
highly
immunosuppressive
microenvironment
promotes
tumor
growth
immune
escape.
addition,
high
accumulation
tumor-infiltrating
leukocytes
other
expression
checkpoint
molecules,
low
mutational
burden,
i.e.,
number
neoantigens,
hallmarks
GBM
challenge
therapeutic
approaches.
Here,
we
review
exploits
support
potential
treatments.
These
include
new
chemotherapeutics,
treating
fields,
small
compounds
targeting
or
blockers
tyrosine
kinases
inhibit
cell
survival.
focus
on
immunotherapies
such
as
blockade
in
particular
vaccination
with
dendritic
cells
CAR-T
which
can
either
kill
directly
bypass
immunosuppression
by
modulating
boosting
patient's
own
response.
Язык: Английский
The potential link between the development of Alzheimer’s disease and osteoporosis
Biogerontology,
Год журнала:
2025,
Номер
26(1)
Опубликована: Янв. 20, 2025
Язык: Английский
Potential of Curcumin and Its Analogs in Glioblastoma Therapy
Antioxidants,
Год журнала:
2025,
Номер
14(3), С. 351 - 351
Опубликована: Март 18, 2025
Curcumin,
a
polyphenol
found
in
turmeric,
demonstrates
multifaceted
anti-cancer
activity
against
glioblastoma.
Its
therapeutic
potential
stems
from
its
ability
to
modulate
various
molecular
pathways
implicated
glioblastoma
development
and
progression,
enhance
the
effectiveness
of
radiation
therapy,
induce
cancer
cell
death
through
diverse
mechanisms,
including
apoptosis,
autophagy,
cycle
arrest.
These
combined
actions
make
curcumin
promising
candidate
for
treatment,
warranting
further
investigation
into
clinical
application.
In
this
review,
we
summarize
latest
research
on
analogs'
therapy.
Язык: Английский