Therapeutic potential of fecal microbiota transplantation in colorectal cancer based on gut microbiota regulation: from pathogenesis to efficacy DOI Creative Commons

Chen Gu,

Gengyu Sha, Baoqing Zeng

и другие.

Therapeutic Advances in Gastroenterology, Год журнала: 2025, Номер 18

Опубликована: Янв. 1, 2025

Colorectal cancer (CRC) remains a leading cause of cancer-related deaths worldwide, with its progression intricately linked to gut microbiota dysbiosis. Disruptions in microbial homeostasis contribute tumor initiation, immune suppression, and inflammation, establishing the as key therapeutic target. Fecal transplantation (FMT) has emerged transformative approach restore balance, enhance responses, reshape microenvironment. This review explores mechanisms underlying FMT’s potential, evaluates advantages over other microbiota-based interventions, addresses challenges such donor selection, safety concerns, treatment standardization. Looking forward, integration FMT into personalized CRC therapies requires robust clinical trials identification predictive biomarkers optimize efficacy safety.

Язык: Английский

Microbiome Integrity Enhances the Efficacy and Safety of Anticancer Drug DOI Creative Commons
Alice Njolke Mafe, Dietrich Büsselberg

Biomedicines, Год журнала: 2025, Номер 13(2), С. 422 - 422

Опубликована: Фев. 10, 2025

The intricate relationship between anticancer drugs and the gut microbiome influences cancer treatment outcomes. This review paper focuses on role of integrity in enhancing efficacy safety drug therapy, emphasizing pharmacokinetic interactions microbiota. It explores how disruptions to composition, or dysbiosis, can alter metabolism, immune responses, side effects. By examining mechanisms disruption caused by drugs, this highlights specific case studies like cyclophosphamide, 5-fluorouracil, irinotecan, their impact microbial diversity clinical also discusses microbiome-targeted strategies, including prebiotics, probiotics, postbiotics, fecal microbiota transplantation (FMT), as promising interventions enhance treatment. Furthermore, potential profiling personalizing therapy integrating these into practice is explored. Finally, proposes future research directions, developing novel biomarkers a deeper comprehension drug-microbiome interactions, respond current gaps knowledge improve patient outcomes care.

Язык: Английский

Процитировано

1
Therapeutic potential of fecal microbiota transplantation in colorectal cancer based on gut microbiota regulation: from pathogenesis to efficacy DOI Creative Commons

Chen Gu,

Gengyu Sha, Baoqing Zeng

и другие.

Therapeutic Advances in Gastroenterology, Год журнала: 2025, Номер 18

Опубликована: Янв. 1, 2025

Colorectal cancer (CRC) remains a leading cause of cancer-related deaths worldwide, with its progression intricately linked to gut microbiota dysbiosis. Disruptions in microbial homeostasis contribute tumor initiation, immune suppression, and inflammation, establishing the as key therapeutic target. Fecal transplantation (FMT) has emerged transformative approach restore balance, enhance responses, reshape microenvironment. This review explores mechanisms underlying FMT’s potential, evaluates advantages over other microbiota-based interventions, addresses challenges such donor selection, safety concerns, treatment standardization. Looking forward, integration FMT into personalized CRC therapies requires robust clinical trials identification predictive biomarkers optimize efficacy safety.

Язык: Английский

Процитировано

0