International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 136066 - 136066
Опубликована: Сен. 1, 2024
Язык: Английский
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141833 - 141833
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
1
Microorganisms, Год журнала: 2024, Номер 12(3), С. 470 - 470
Опубликована: Фев. 26, 2024
There is currently growing interest in the creation of artificial microbial consortia, especially field developing and applying various bioremediation processes. Heavy metals, dyes, synthetic polymers (microplastics), pesticides, polycyclic aromatic hydrocarbons pharmaceutical agents are among pollutants that have been mainly targeted by based on consortia containing fungi (mycelial types yeasts). Such can be designed both for treatment soil water. This review aimed at analyzing recent achievements research useful environmental technologies, where fungal cells applied. The main tendencies formation certain combinations, preferences their forms usage (suspended or immobilized), evaluated using current publications, place genetically modified with assessed. effect multicomponence estimated, as well influence this factor functioning efficiency pollutant removal efficacy. conclusions development new mixed biocatalysts eco-compatible remediation processes implement cells.
Язык: Английский
Процитировано
5
Salud Ciencia y Tecnología, Год журнала: 2025, Номер 5, С. 1647 - 1647
Опубликована: Март 12, 2025
Mycosis poses a significant threat to global health, particularly in immune-compromised individuals, and the rise of antifungal resistance has further complicated their treatment. The fungal infections (FIs) is growing concern, contributing significantly morbidity mortality rates. Medicinal plants (MPs), with long history use traditional medicine, have emerged as valuable source bioactive compounds potent properties. current study explores mechanisms by which plant active constituents (PACs) exert effects, including inhibition cell membrane (CM) wall (CW) synthesis, mitochondrial dysfunction, Nucleic acids (Nas) protein synthesis (PS), inhibiting electron transport chain, decreasing ATP production, glycolysis, oxidative phosphorylation, oxygen uptake cells, this lead affect division, /or its mycelial growth spore germination. Compounds such flavonoids, alkaloids, terpenoids, other PACs demonstrated activity through these diverse mechanisms, offering potential alternatives conventional drugs. This highlights MPs foundation for developing novel therapies. Furthermore, it underscores importance understanding intraocular action (MsOA) combat improve therapeutic outcomes. comprehensive analysis not only validates medicine but also provides roadmap future research drug development fight against FIs. aligns supports sustainable goals (SDGs), good health well-being (SDG 3) goals.
Язык: Английский
Процитировано
0
Biomolecules, Год журнала: 2024, Номер 14(3), С. 383 - 383
Опубликована: Март 21, 2024
Since the growing number of fungi resistant to fungicides used is becoming a serious threat human health, animals, and crops, there need find other effective approaches in eco-friendly suppression fungal growth. One main mechanisms development resistance fungi, as well bacteria, antimicrobial agents quorum sensing (QS), which various lactone-containing compounds participate signaling molecules. This work aimed study effectiveness action enzymes exhibiting lactonase activity against For this, molecular docking method was estimate interactions between these different QS molecules fungi. The catalytic characteristics such AiiA, metallo-β-lactamase NDM-1, organophosphate hydrolase His6-OPH, selected for wet experiments based on results computational modeling, were investigated. (butyrolactone I γ-heptalactone) involved substrates. Further, antifungal evaluated yeast cells using bioluminescent ATP-metry. efficient hydrolysis γ-heptalactone by all three butyrolactone His6-OPH demonstrated first time. high efficacy AiiA NDM-1 most tested revealed.
Язык: Английский
Процитировано
3
Biomimetics, Год журнала: 2024, Номер 9(7), С. 425 - 425
Опубликована: Июль 12, 2024
In light of rising public health threats like antifungal and antimicrobial resistance, alongside the slowdown in new development, biomimetics have shown promise as therapeutic agents. Multidrug-resistant fungi pose significant challenges they quickly develop making traditional antifungals less effective. Developing is also complicated by need to target eukaryotic cells without harming host. This review examines biomimetic materials that mimic natural biological mechanisms for targeted efficient action. It covers a range agents, including peptides, alginate-based antifungals, chitosan derivatives, nanoparticles, plant-derived polyphenols, probiotic bacteria. These agents work through such disrupting cell membranes, generating reactive oxygen species, inhibiting essential fungal processes. Despite their potential, remain terms ensuring biocompatibility, optimizing delivery, overcoming potential resistance. Production scalability economic viability are concerns. Future research should enhance stability efficacy these materials, integrate multifunctional approaches, sophisticated delivery systems. Interdisciplinary efforts needed understand interactions between cells, host environment. Long-term environmental impacts, resistance mechanisms, standardized testing protocols require further study. conclusion, while represent revolutionary approach combating multidrug-resistant fungi, extensive development fully realize potential.
Язык: Английский
Процитировано
1
Microorganisms, Год журнала: 2024, Номер 12(8), С. 1650 - 1650
Опубликована: Авг. 12, 2024
The unresolved challenges in the development of highly efficient, stable and controlled synthetic microbial consortia, as well use natural are very attractive for science technology. However, consortia management should be done with knowledge how not only to accelerate but also stop action such "little pots". Moreover, there a lot activity which suppressively controlled. processes, catalyzed by various microorganisms being complex slowed down or completely cancelled, typical environment (biocorrosion, landfill gas accumulation, biodegradation building materials, water sources deterioration etc.), industry (food biotechnological production), medical practice (vaginitis, cystitis, intestinal dysbiosis, etc.). search ways suppress functioning heterogeneous each these areas is relevant. purpose this review summarize general trends studies regarding targets new means influence used. analysis features applied approaches solving main problem confirms possibility obtaining combined effect, selective on individual components consortia. Of particular interest role viruses suppressing different compositions.
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 136066 - 136066
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
1