Wet chemical synthesis of nanohydroxyapatite within poly(sodium sulfonated butylene fumarate‐co‐acrylic acid) as bone scaffold: effects of sulfonate and carboxylic acid groups DOI Open Access

Nadia Mahmoudzadeh,

Hadi Shirali, Faramarz Afshar Taromi

и другие.

Polymer International, Год журнала: 2024, Номер unknown

Опубликована: Дек. 22, 2024

Abstract This study investigates the synthesis, nucleation and modification of biodegradable poly(sodium sulfonated butylene fumarate‐ co ‐acrylic acid)/hydroxyapatite nanocomposite scaffolds for bone tissue engineering, with a focus on effects incorporating hydrophilic sulfonate carboxylic acid groups. Poly(butylene fumarate) was at varying degrees used to form nanocomposites through in situ nanohydroxyapatite (nHA) simulated body fluid solution. Critical parameters such as water absorption, swelling behavior, mechanical properties, nanoparticle dispersion biocompatibility were evaluated. Water uptake ratios ranged from 2.72 6.88 g −1 , while compressive modulus values increased up 25.9 times compared corresponding homopolymers, demonstrating improved stability. Despite formation over 80% nanoparticles, well‐distributed nHA, sizes averaging 39 ± 13 nm, achieved incorporation groups, preventing agglomeration within scaffold matrix. Additionally, supported human dermal fibroblast adhesion proliferation, cell viability remaining high throughout culture period. These results suggest that developed offer enhanced biocompatibility, strength osteogenic potential, making them promising candidates regeneration applications. © 2024 Society Chemical Industry.

Язык: Английский

Process Development for Fabricating 3D-Printed Polycaprolactone-Infiltrated Hydroxyapatite Bone Graft Granules: Effects of Infiltrated Solution Concentration and Agitating Liquid DOI Creative Commons

Faungchat Thammarakcharoen,

Autcharaporn Srion, Waraporn Suvannapruk

и другие.

Biomedicines, Год журнала: 2024, Номер 12(9), С. 2161 - 2161

Опубликована: Сен. 23, 2024

Bone grafts are commonly used in orthopedic and dental surgeries to facilitate bone repair regeneration. A new type of graft, polycaprolactone-infiltrated three dimensionally printed hydroxyapatite (3DP HA/PCL), was previously developed by infiltrating polycaprolactone (PCL) into preformed three-dimensional-printed HA) that fabricated using binder jetting technology combined with a low-temperature phase transformation process. However, when producing small granules, which often for grafting, issues granule agglomeration emerged, complicating the application this method. This study aimed develop fabrication process 3DP HA/PCL graft granules solution infiltration liquid agitation. The effects varying PCL concentrations (40% 50% w/w) different agitating liquids (deionized water or DI, N-Methyl-2-Pyrrolidone NMP, an NMP-DI mixture) on properties resulting composites were investigated. XRD FTIR analysis confirmed coexistence HA within composites. final content comparable across all conditions. contact angles 26.3 69.8 degree 40% solution, respectively, but zero NMP NMP-DI. highest compression load resistance diametral tensile strength achieved DI mixture. resulted dense coating, while mixture produced porous irregular surface morphology. All samples exhibited internal microstructure due initial pores 3D-printed HA. Biocompatibility tests showed supported proliferation MC3T3-E1 cells, greatest OD values observed at each cultured period. Considering microstructural, mechanical, biological properties, demonstrated overall desirable properties.

Язык: Английский

Процитировано

0
3D Bioprinting of Alginate Biogel with Gelatin-Coated Octa-Calcium Phosphate Micro/Nanoparticles for Bone Tissue Engineering DOI

Nelli Tolmacheva,

Amitava Bhattacharyya,

DaJeong Kim

и другие.

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0
3D Bioprinting of Alginate Biogel with Gelatin-Coated Octa-Calcium Phosphate Micro/Nanoparticles for Bone Tissue Engineering DOI

Nelli Tolmacheva,

Amitava Bhattacharyya,

DaJeong Kim

и другие.

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0
Wet chemical synthesis of nanohydroxyapatite within poly(sodium sulfonated butylene fumarate‐co‐acrylic acid) as bone scaffold: effects of sulfonate and carboxylic acid groups DOI Open Access

Nadia Mahmoudzadeh,

Hadi Shirali, Faramarz Afshar Taromi

и другие.

Polymer International, Год журнала: 2024, Номер unknown

Опубликована: Дек. 22, 2024

Abstract This study investigates the synthesis, nucleation and modification of biodegradable poly(sodium sulfonated butylene fumarate‐ co ‐acrylic acid)/hydroxyapatite nanocomposite scaffolds for bone tissue engineering, with a focus on effects incorporating hydrophilic sulfonate carboxylic acid groups. Poly(butylene fumarate) was at varying degrees used to form nanocomposites through in situ nanohydroxyapatite (nHA) simulated body fluid solution. Critical parameters such as water absorption, swelling behavior, mechanical properties, nanoparticle dispersion biocompatibility were evaluated. Water uptake ratios ranged from 2.72 6.88 g −1 , while compressive modulus values increased up 25.9 times compared corresponding homopolymers, demonstrating improved stability. Despite formation over 80% nanoparticles, well‐distributed nHA, sizes averaging 39 ± 13 nm, achieved incorporation groups, preventing agglomeration within scaffold matrix. Additionally, supported human dermal fibroblast adhesion proliferation, cell viability remaining high throughout culture period. These results suggest that developed offer enhanced biocompatibility, strength osteogenic potential, making them promising candidates regeneration applications. © 2024 Society Chemical Industry.

Язык: Английский

Процитировано

0