Syzygium aromaticum extract mediated, sustainable silver nanoparticle synergetic with heterocyclic antibiotic clarithromycin and their antimicrobial activities

Frontiers in Chemistry, Год журнала: 2025, Номер 12

Опубликована: Янв. 15, 2025

Microorganisms are becoming resistant to drugs and antimicrobials, making it a significantly critical global issue. Nosocomial infections resulting in alarmingly increasing rates of morbidity mortality. Plant derived compounds hold numerous antimicrobial properties, them very capable source counteract microbial strains. Syzygium aromaticum (Clove) extract has been proven by studies contain active ingredients that demonstrate antibacterial, antifungal, antioxidant, insecticidal properties. It also used historically for its pain relief especially tooth ache. Clove nanoparticle synthesis is promising method combining therapeutics with metals at nanoscale. Such nanostructured systems combination the heterocyclic antibiotic clarithromycin could potentiate action plant extracts, decrease drug side effects improve activity. In this study, clove (C) was successfully synthesize silver nanoparticles (AgNP) create AgNPC AgNPCA (A = clarithromycin). The two underwent different analytical methods consisting SEM, EDS, DLS, UV-vis, FTIR XRD. These were against variety 10 pathogens exhibited good intermediate antibacterial resulted better properties smaller size. This study demonstrates potential mediated AgNP without clarithromycin.

Язык: Английский

Bio-Based Interpolyelectrolyte Complexes for the Stabilization of Pickering-like Emulsions

Colloids and Interfaces, Год журнала: 2025, Номер 9(1), С. 9 - 9

Опубликована: Янв. 22, 2025

This work studies the stabilization of Pickering-like emulsions using dispersions interpolyelectrolyte complexes (IPECs) formed by chitosan (CS) and sodium alginate (ALG), two polymers from natural resources, as aqueous phase soybean oil phase. The ability these bio-based IPECs to form stable was evaluated varying compositional ratio CS ALG (Z-ratio) volume fraction (ϕo). Turbidity, zeta potential, dynamic light scattering measurements revealed dependence IPEC properties on Z-ratio, with separation observed near stoichiometric ratios. Phase diagram analysis showed that oil-in-water (O/W) water-in-oil (W/O) could be obtained under certain combinations Z-ratio ϕo. Emulsion stability increased higher Z-ratios due interfacial activity reduced coalescence. Emulsions high ϕo exhibited transitions discrete droplets bicontinuous interfacially jammed emulsion gels (bijels), suggesting tunable morphologies. These results highlight potential CHI-ALG eco-friendly efficient stabilizers for applications in food, cosmetics pharmaceuticals.

Язык: Английский

Hydrogen bond-driven interactions between chitosan and biobased surfactants: A study of bulk behavior and surface adsorption

Journal of Molecular Liquids, Год журнала: 2025, Номер unknown, С. 127259 - 127259

Опубликована: Фев. 1, 2025

Язык: Английский