Current Topics in Medicinal Chemistry,
Год журнала:
2024,
Номер
24(11), С. 986 - 1009
Опубликована: Апрель 1, 2024
This
review
explores
the
advancements
in
nanomaterial-based
electrochemical
sensors
for
multiplex
detection
of
medicinal
compounds.
The
growing
demand
efficient
and
selective
methods
pharmaceutical
field
has
prompted
significant
research
into
development
employing
nanomaterials.
These
materials,
defined
as
functional
materials
with
at
least
one
dimension
between
1
100
nanometers,
encompass
metal
nanoparticles,
polymers,
carbon-based
nanocomposites,
nano-bioprobes.
are
characterized
by
their
enhanced
sensitivity
selectivity,
playing
a
crucial
role
simultaneous
offering
comprehensive
analysis
multiple
complexes
within
single
sample.
comprehensively
examines
design,
fabrication,
application
nanomaterial-
based
sensors,
focusing
on
ability
to
achieve
various
substances.
Insights
strategies
nanomaterials
employed
enhancing
sensor
performance
discussed.
Additionally,
challenges
future
perspectives
this
evolving
field,
highlighting
potential
impact
advancement
technologies.
Chemosensors,
Год журнала:
2023,
Номер
11(7), С. 388 - 388
Опубликована: Июль 12, 2023
Neurotransmitters
(NTs)
play
a
crucial
role
in
regulating
the
behavioral
and
physiological
functions
of
nervous
system.
Imbalances
concentrations
NT
have
been
directly
linked
to
various
neurological
diseases
(e.g.,
Parkinson’s,
Huntington’s,
Alzheimer’s
disease),
addition
multiple
psychotic
disorders
such
as
schizophrenia,
depression,
dementia,
other
neurodegenerative
disorders.
Hence,
rapid
real-time
monitoring
NTs
is
utmost
importance
comprehending
identifying
Among
different
sensing
techniques,
electrochemical
biosensors
garnered
significant
interest
due
their
ability
deliver
fast
results,
compatibility
for
miniaturization
portability,
high
sensitivity,
good
controllability.
Furthermore,
utilization
enzymes
recognition
elements
biosensing
design
has
renewed
attention
unique
advantages
catalytic
biorecognition
coupled
with
simultaneous
signal
amplification.
This
review
paper
primarily
focuses
on
covering
recent
advances
enzymatic
detection
NTs,
encompassing
sensors,
electrode
materials,
electroanalytical
techniques.
Moreover,
we
shed
light
applications
enzyme-based
complex
matrices
vivo
monitoring.
Despite
numerous
biosensors,
there
are
still
challenges
that
need
be
addressed,
which
thoroughly
discussed
this
paper.
Finally,
also
presents
an
outlook
future
perspectives
opportunities
development
detection.
RSC Sustainability,
Год журнала:
2024,
Номер
2(4), С. 832 - 851
Опубликована: Янв. 1, 2024
Nanoplastic
residues
in
our
aquatic
ecosystems
poses
a
serious
global
concern
which
needs
effective
monitoring
to
implement
actions
and
control
measures.
Electrochemical
chemo(bio)sensors
emerge
as
promising
tool
for
their
detection
protect
water
environmental
resources.
Critical Reviews in Analytical Chemistry,
Год журнала:
2024,
Номер
unknown, С. 1 - 22
Опубликована: Март 10, 2024
Catecholamines
(CAs),
which
include
adrenaline,
noradrenaline,
and
dopamine,
are
neurotransmitters
hormones
that
critically
regulate
the
cardiovascular
system,
metabolism,
stress
response
in
human
body.
The
abnormal
levels
of
these
molecules
can
lead
to
development
various
diseases,
including
pheochromocytoma
paragangliomas,
Alzheimer's
disease,
Takotsubo
cardiomyopathy.
Due
their
low
cost,
high
sensitivity,
flexible
detection
strategies,
ease
integration,
miniaturization,
electrochemical
techniques
have
been
extensively
employed
CAs,
surpassing
traditional
analytical
methods.
Electrochemical
CAs
real
samples
is
challenging
due
tendency
poisoning
electrode.
Chemically
modified
electrodes
widely
used
solve
problems
poor
sensitivity
selectivity
faced
by
bare
electrodes.
There
a
few
articles
provide
an
overview
efficient
enrichment
but
there
dearth
updates
on
role
pathogenesis
diseases.
Additionally,
still
lack
systematic
synthesis
with
focus
for
detection.
Thus,
this
review
provides
summary
recent
clinical
published
between
2017
2022.
Moreover,
challenges
future
perspectives
also
highlighted.
This
work
expected
useful
guidance
researchers
entering
interdisciplinary
field,
promoting
further
pathogenesis,
developing
more
novel
chemically
CAs.
Alexandria Engineering Journal,
Год журнала:
2023,
Номер
85, С. 294 - 299
Опубликована: Ноя. 22, 2023
The
human
gut
microbiota
plays
a
vital
role
in
health
and
disease.
Indole
derivatives
like
indole,
tryptamine
indoxyl
sulfate
represent
important
microbiota-associated
metabolites
biomarkers
of
function.
However,
current
techniques
for
analysis
these
mass
spectrometry
HPLC
suffer
from
limitations
including
high
cost,
complex
sample
preparation
procedures,
long
times.
In
contrast,
electrochemical
sensing
offers
rapid,
simple
low-cost
alternative
with
potential
point-of-care
applications.
We
report
nanotip
array-based
platform
sensitive
quantification
indole
derivatives.
Silicon
arrays
were
fabricated
controlled
sub-micron
morphology
coated
gold
to
form
electrodes.
Further
modification
silver
nanoparticles
(AgNPs)
led
significantly
enhanced
signal.
Using
differential
pulse
voltammetry
(DPV),
distinct
oxidation
peaks
observed
sulfate,
enabling
detection
down
nM
levels.
A
broad
linear
dynamic
range
7
orders
magnitude
demonstrated
excellent
quantitative
capabilities.
sensor
showed
reproducibility
(<5
%
RSD)
selectivity
the
presence
interferents.
Importantly,
accurate
spiked
was
achieved
biological
samples
serum
fecal
extracts.
capacity
rapidly
quantify
minimally
processed
highlights
this
strategy
Overall,
work
provides
robust
nanotechnology-enabled
metabolite
profiling
elucidate
Arabian Journal for Science and Engineering,
Год журнала:
2024,
Номер
49(7), С. 9053 - 9065
Опубликована: Янв. 19, 2024
Abstract
Nerve
agents,
including
organophosphorus
compounds
such
as
paraoxon,
are
potent
and
highly
toxic
chemicals
with
grave
implications
for
human
health
the
environment.
In
this
paper,
we
present
development
of
a
novel
enzyme
inhibition-based
biosensor
sensitive
selective
detection
which
is
commonly
used
surrogate
nerve
agents.
The
employs
reduced
graphene
oxide
screen-printed
electrode
surface
modification
nanomaterial,
leading
to
increased
electroactivity
and,
thus,
more
detection.
exhibits
low
limit
0.56
pg/ml
(limit
detection,
LOD)
1.25
quantification,
LOQ),
highlighting
its
high
sensitivity
trace-level
analysis
agents
in
complex
sample
matrices.
Our
demonstrates
remarkable
selectivity
minimal
interference
from
other
non-target
chemicals.
Stability
repeatability
tests
reveal
that
system
maintains
performance
integrity
over
45-day
period
consistently
produces
readings
margin
error
only
5%.
Real
testing
river
water,
wastewater,
tap
water
further
confirms
biosensor's
practical
utility,
recovery
percentages
ranging
84
115%.
This
represents
significant
advancement
technology,
facilitating
rapid,
cost-effective,
reliable
substances
real-world
scenarios.
