Biosensors,
Год журнала:
2024,
Номер
14(12), С. 580 - 580
Опубликована: Ноя. 28, 2024
Point-of-care
(POC)
immunoassays
have
become
convincing
alternatives
to
traditional
immunosensing
methods
for
the
sensitive
and
real-time
detection
of
targets.
Immunoassays
based
on
gas-generating
reactions
were
recently
developed
been
used
in
various
fields
due
their
advantages,
such
as
rapid
measurement,
direct
reading,
simple
operation,
low
cost.
Enzymes
or
nanoparticles
modified
with
antibodies
can
effectively
catalyze
convert
immunorecognition
events
into
gas
pressure
signals,
which
be
easily
recorded
by
multifunctional
portable
devices.
This
article
summarizes
advances
gas-generating-reaction-based
immunoassays,
according
different
types
signal
output
systems,
including
distance-based
readout,
differential,
visualized
detection,
thermal
measurement.
The
review
mainly
focuses
role
photothermal
materials
working
principle
immunoassays.
In
addition,
challenges
prospects
future
development
are
briefly
discussed.
Molecules,
Год журнала:
2024,
Номер
29(12), С. 2796 - 2796
Опубликована: Июнь 12, 2024
Enzyme-linked
electrochemical
immunosensors
have
attracted
considerable
attention
for
the
sensitive
and
selective
detection
of
various
targets
in
clinical
diagnosis,
food
quality
control,
environmental
analysis.
In
order
to
improve
performances
conventional
immunoassays,
significant
efforts
been
made
couple
enzyme-linked
or
nanozyme-based
catalysis
redox
cycling
signal
amplification.
The
current
review
summarizes
recent
advances
development
enzyme-
with
special
features
reactions
their
synergistic
functions
amplification
are
discussed.
Additionally,
challenges
future
directions
addressed.
Accounts of Chemical Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 12, 2025
ConspectusBoronic
acids
(BAs)
are
one
of
the
most
important
classes
reagents
in
modern
synthesis,
enabling
a
wide
range
powerful
transformations
that
facilitate
formation
key
carbon–carbon
and
carbon–heteroatom
bonds.
While
their
success
as
is
well-known,
remarkable
potential
building
blocks
for
creating
functional
molecules
often
overlooked.At
core
BAs'
uniqueness
ability
to
form
reversible
covalent
bonds,
thanks
interconversion
boron
atom
between
its
uncharged
trigonal
planar
structure
an
anionic
sp3-hybridized
form.
This
coordination
chemistry
has
paved
way
exciting
developments
fields
such
medicinal
chemical
biology.
In
recent
years,
BAs
have
been
used
create
variety
materials,
including
small-molecule
drugs,
bioconjugates,
drug
delivery
vehicles,
polymeric
nanomaterials,
sensors,
even
photosensitizers.
What
makes
this
strategy
particularly
unique
structural
diversity
can
be
achieved
by
functionalizing
BA
sphere,
along
with
possibility
incorporating
stimuli-responsive
mechanisms.
reactivity
further
enhanced
well-known
oxidation
presence
reactive
oxygen
species
(ROS).A
detailed
understanding
mechanisms
governing
dynamic
nature
enables
engineering
sophisticated
materials
respond
specific
molecular
stimuli,
changes
pH,
carbohydrate
or
glutathione
concentrations,
hydrogen
peroxide.
These
stimuli
indicators
diseases
cancer,
inflammation,
neurodegeneration,
placing
at
forefront
tools
designing
potentially
influence
behind
these
diseases.In
Account,
we
draw
on
our
group's
expertise
explore
design
materials.
The
focus
response
different
complexes
biologically
relevant
stimuli.
We
describe
preparation
boronated
esters
(BEs),
BA–salicylhydroxamic
acid
(BA–SHA)
complexes,
iminoboronates,
diazaborines,
thiazolidines
discuss
how
chemotypes
disease-relevant
triggers.
Given
growing
importance
using
external
control
efficacy
also
some
compounds
chemicals.
Account
not
meant
exhaustive
survey
every
example
stimulus-responsiveness,
aim
integrate
existing
Our
goal
provide
overview
enabled
could
day
lead
innovative
therapeutic
options
human
diseases.
Drug-resistant
bacterial
infections
are
among
the
most
severe
physiological
challenges
facing
human
health.
Therefore,
detection
and
inactivation
of
pathogenic
bacteria
remains
a
crucial
therapeutic
goal
in
modern
society.
In
this
study,
we
design
multifunctional
nanocomposites
aimed
at
binding,
fluorescence
labeling,
synergistic
antibacterial
treatment.
These
prepared
by
introducing
cationic
polymers
with
quaternary
ammonium
compounds
onto
silica
nanoparticles
using
surface-initiated
atom
transfer
radical
polymerization,
followed
incorporation
copper-doped
carbon
dots
modification
boronic
acid.
The
polymer
units
acid
end
groups
enhance
binding
capacity
bactericidal
effects
cooperation
dots.
Due
to
stable
fluorescent
properties
dots,
can
generate
signals
around
bacteria,
enabling
imaging.
Overall,
study
demonstrates
nanocomposite-assisted
strategy
for
imaging,
deactivation,
providing
novel
approach
Sensors,
Год журнала:
2024,
Номер
24(16), С. 5442 - 5442
Опубликована: Авг. 22, 2024
Saccharides,
being
one
of
the
fundamental
molecules
life,
play
essential
roles
in
physiological
and
pathological
functions
cells.
However,
their
intricate
structures
pose
challenges
for
detection.
Nanopore
technology,
with
its
high
sensitivity
capability
single-molecule-level
analysis,
has
revolutionized
identification
structural
analysis
saccharide
molecules.
This
review
focuses
on
recent
advancements
nanopore
technology
carbohydrate
detection,
presenting
an
array
methods
that
leverage
molecular
complexity
saccharides.
Biological
techniques
utilize
specific
protein
binding
or
pore
modifications
to
trigger
typical
resistive
pulses,
enabling
high-sensitivity
detection
monosaccharides
oligosaccharides.
In
solid-state
sensing,
boronic
acid
modification
pH
gating
mechanisms
are
employed
recognition
quantitative
polysaccharides.
The
integration
artificial
intelligence
algorithms
can
further
enhance
accuracy
reliability
analyses.
Serving
as
a
crucial
tool
we
foresee
significant
potential
application
disease
diagnosis,
drug
screening,
biosensing,
fostering
innovative
progress
related
research
domains.
