Recent Advancements in Fused Deposition Modeling
Polymers for Advanced Technologies,
Год журнала:
2025,
Номер
36(1)
Опубликована: Янв. 1, 2025
ABSTRACT
Additive
manufacturing
(AM)
is
a
continuously
growing
field
composed
of
numerous
part‐building
approaches
that
involve
the
creation
products
in
layer‐by‐layer
fashion.
Fused
deposition
modeling
(FDM)
three‐dimensional
printing
or
AM
technique
being
adopted
on
an
industrial
scale
and
utilized
to
make
parts
for
commercial
use
mainly
medical
sector
these
days.
It
has
become
need
hour
study
parameters
FDM
understand
print
behavior
optimize
process
with
better
mechanical
properties.
This
review
paper
provides
understanding
development
optimization
various
materials
like
Nylon,
polylactic
acid
(PLA),
acrylonitrile
butadiene
styrene
(ABS),
polyether
ether
ketone
(PEEK)
by
utilizing
different
designs
techniques
Taguchi
response
surface
methodology.
Regarding
relevant
properties,
influence
layer
thickness,
raster
angle,
build
orientations,
width,
infill
density
are
underlined
carefully.
The
also
concludes
optimized
obtain
best
properties
such
as
tensile
flexural
strength
PLA,
PEEK,
ABS.
literature
up‐to‐date
references
highlights
future
recommendations
fabricated
components.
Язык: Английский
Lymphoma-on-chip model reveals that lymph node stromal cells promote diffuse large B-cell lymphoma survival and migration
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101544 - 101544
Опубликована: Фев. 7, 2025
Diffuse
large
B-cell
lymphoma
(DLBCL)
is
the
most
common
aggressive
non-Hodgkin
lymphoma,
often
developing
resistance
to
current
treatments.
Development
and
testing
of
new
therapies
hampered
by
lack
good
in
vivo
vitro
models
mimicking
human
disease.
Here,
we
developed
a
lymphoma-on-chip
model
investigate
tumor-supportive
roles
lymph
node
stromal
cells
(LNSCs)
-
fibroblastic
reticular
(FRCs)
lymphatic
endothelial
(LECs)
DLBCL
microenvironment.
The
includes
tubular
vessel
lined
with
LECs
surrounded
hydrogel
FRCs.
Our
findings
reveal
that
FRCs
promote
survival
facilitate
tumor
cell
migration
towards
vessels.
Moreover,
demonstrate
increase
permeability
vessels,
which
further
enhanced
presence
This
reveals
important
role
LNSCs
progression,
offers
an
innovative
tool
study
microenvironment
test
potential
therapeutic
targets
improve
patient
outcomes.
Язык: Английский
Tumor Microenvironment Based on Extracellular Matrix Hydrogels for On-Chip Drug Screening
Biosensors,
Год журнала:
2024,
Номер
14(9), С. 429 - 429
Опубликована: Сен. 5, 2024
Recent
advances
in
three-dimensional
(3D)
culturing
and
nanotechnology
offer
promising
pathways
to
overcome
the
limitations
of
drug
screening,
particularly
for
tumors
like
neuroblastoma.
In
this
study,
we
develop
a
high-throughput
microfluidic
chip
that
integrates
concentration
gradient
generator
(CGG)
with
3D
co-culture
system,
constructing
vascularized
microenvironment
by
co-culturing
neuroblastoma
(SY5Y
cell
line)
human
brain
microvascular
endothelial
cells
(HBMVECs)
within
decellularized
extracellular
matrix
(dECM)
hydrogels.
The
automated
platform
enhances
simulation
tumor
allows
precise
control
concentrations
nanomedicines,
which
is
crucial
evaluating
therapeutic
efficacy.
findings
demonstrate
can
significantly
accelerate
discovery.
It
efficiently
screens
analyzes
interactions
biologically
relevant
setting,
potentially
revolutionizing
screening
process.
Язык: Английский
Microscale Flow Control and Droplet Generation Using Arduino-Based Pneumatically-Controlled Microfluidic Device
Biosensors,
Год журнала:
2024,
Номер
14(10), С. 469 - 469
Опубликована: Сен. 30, 2024
Microfluidics
are
crucial
for
managing
small-volume
analytical
solutions
various
applications,
such
as
disease
diagnostics,
drug
efficacy
testing,
chemical
analysis,
and
water
quality
monitoring.
The
precise
control
of
flow
devices
can
generate
diverse
patterns
using
pneumatic
with
solenoid
valves
a
microcontroller.
This
system
enables
the
active
modulation
pressure
through
Arduino
programming
connected
to
source.
Additionally,
incorporation
valve
sets
allows
multichannel
control,
enabling
simultaneous
creation
manipulation
microflows
at
low
cost.
proposed
microfluidic
controller
facilitates
accurate
regulation,
especially
periodic
beneficial
droplet
generation
continuous
production
microdroplets
different
sizes.
Overall,
we
expect
drive
innovative
advancements
in
technology
medicine
owing
its
engineering
precision
versatility.
Язык: Английский