Preparation of Ca-Mg Double-Doped Mesoporous Silica Nanoparticles and Their Drug-Loading and Drug-Releasing Properties DOI Creative Commons
Qian Zhang, Jiamin Huang, Chao Liu

и другие.

Inorganics, Год журнала: 2025, Номер 13(1), С. 12 - 12

Опубликована: Янв. 4, 2025

Breast cancer is a common clinical malignant tumor that seriously threatens women’s physical and mental health. Chemotherapy, as the first choice of breast treatment, has limited its application in clinic due to problems poor stability, short half-life, serious toxic side effects. With emergence nanotechnology, inorganic materials prepare mesoporous silica nanoparticles (MSNs) have been widely used anti-tumor drug carriers. However, their slow degradation rate limits biomedical field. Therefore, developing low-toxicity MSNs with good biocompatibility, biodegradability, rapid release at site key scientific issue be addressed. Here, we prepared DOX-loaded Ca-Mg-doped by electrostatic adsorption obtain Ca-Mg@DOX@MSNs suitable particle sizes zeta potential, incorporation calcium magnesium also led an increase under acidic conditions accelerated release, which reduced toxicity DOX promoted cellular uptake This study provides new idea for treatment cancer.

Язык: Английский

Preparation of Ca-Mg Double-Doped Mesoporous Silica Nanoparticles and Their Drug-Loading and Drug-Releasing Properties DOI Creative Commons
Qian Zhang, Jiamin Huang, Chao Liu

и другие.

Inorganics, Год журнала: 2025, Номер 13(1), С. 12 - 12

Опубликована: Янв. 4, 2025

Breast cancer is a common clinical malignant tumor that seriously threatens women’s physical and mental health. Chemotherapy, as the first choice of breast treatment, has limited its application in clinic due to problems poor stability, short half-life, serious toxic side effects. With emergence nanotechnology, inorganic materials prepare mesoporous silica nanoparticles (MSNs) have been widely used anti-tumor drug carriers. However, their slow degradation rate limits biomedical field. Therefore, developing low-toxicity MSNs with good biocompatibility, biodegradability, rapid release at site key scientific issue be addressed. Here, we prepared DOX-loaded Ca-Mg-doped by electrostatic adsorption obtain Ca-Mg@DOX@MSNs suitable particle sizes zeta potential, incorporation calcium magnesium also led an increase under acidic conditions accelerated release, which reduced toxicity DOX promoted cellular uptake This study provides new idea for treatment cancer.

Язык: Английский

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