Neurology neuropsychiatry Psychosomatics,
Год журнала:
2024,
Номер
16(3), С. 26 - 30
Опубликована: Июнь 21, 2024
Objective
:
to
determine
the
sensitivity
and
specificity
of
method
determining
concentration
immunoglobulin
free
light
chains
(FLCs)
in
cerebrospinal
fluid
(CSF)
diagnosis
differential
multiple
sclerosis
(MS).
Material
methods
.
80
patients
participated
study.
The
main
group
consisted
54
diagnosed
with
MS
according
2017
McDonald
criteria.
comparison
(n=26)
comprised
other
diseases
nervous
system.
An
enzyme-linked
immunosorbent
assay
(ELISA)
was
used
FLCs
(kappa-
lambda-chains)
CSF.
Results
In
MS,
an
increase
kappa-chains
(к-FLCs)
CSF
found
compared
(p<0.001).
With
κ-FLCs,
a
decrease
for
observed.
к-FLCs
cut-off
value
0.17
μg/ml
had
68.5
%
92.3
%.
0.22
59.3
100
concentrations
lambda-FLCs
comparison,
did
not
differ
significantly
(p=0.1).
Conclusion
results
obtained
indicate
patients.
This
biomarker
showed
high
this
pathology.
However,
further
development
optimal
thresholds
is
required
clarify
diagnostic
Multiple Sclerosis Journal,
Год журнала:
2020,
Номер
26(14), С. 1816 - 1821
Опубликована: Ноя. 11, 2020
Background:
High-quality
epidemiologic
data
worldwide
are
needed
to
improve
our
understanding
of
disease
risk,
support
health
policy
meet
the
diverse
needs
people
with
multiple
sclerosis
(MS)
and
advocacy
efforts.
Objectives:
The
Atlas
MS
is
an
open-source
global
compendium
regarding
epidemiology
availability
resources
for
reported
at
country,
regional
levels.
Methods:
Country
representatives
their
sources
via
survey
between
September
2019
March
2020,
covering
prevalence
incidence
in
males,
females
children,
age
type
diagnosis.
Regional
analyses
comparisons
2013
were
conducted.
Results:
A
total
2.8
million
estimated
live
(35.9
per
100,000
population).
has
increased
every
world
region
since
but
gaps
estimates
persist.
pooled
rate
across
75
reporting
countries
2.1
persons/year,
mean
diagnosis
32
years.
Females
twice
as
likely
males.
Conclusions:
risen
2013,
good
surveillance
not
universal.
Action
by
stakeholders
close
knowledge
gaps.
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Сен. 23, 2022
Multiple
sclerosis
(MS)
is
a
chronic
inflammatory
disease
of
the
central
nervous
system
(CNS)
characterized
by
destruction
myelin
sheath
structure.
The
loss
leads
to
damage
neuron’s
axon
and
cell
body,
which
identified
as
brain
lesions
on
magnetic
resonance
image
(MRI).
pathogenesis
MS
remains
largely
unknown.
However,
immune
mechanisms,
especially
those
linked
aberrant
lymphocyte
activity,
are
mainly
responsible
for
neuronal
damage.
Th1
Th17
populations
lymphocytes
were
primarily
associated
with
pathogenesis.
These
essential
differentiation
encephalitogenic
CD8
+
T
crossing
blood
barrier
targeting
in
CNS.
B-lymphocytes
could
also
contribute
producing
anti-myelin
basic
protein
antibodies.
In
later
studies,
function
Treg
Th9
cells
was
contributing
MS.
This
review
summarizes
count
lymphocyte,
contributions
these
mechanisms
Additionally,
we
have
outlined
novel
therapeutics
aimed
amend
or
counts
lymphocytes.
Pakistan Journal of Medical Sciences,
Год журнала:
2025,
Номер
41(2), С. 437 - 442
Опубликована: Янв. 23, 2025
Objectives:
To
investigate
the
clinico-epidemiological
characteristics
of
multiple
sclerosis
(MS)
in
southern
region
Republic
Azerbaijan,
which
has
a
population
930,601.
Methods:
This
prospective,
single-center,
longitudinal
study
was
conducted
from
January
1,
2013,
to
December
31,
2022.
MS
patients
this
underwent
examination
and
treatment
under
State
Program.
During
period,
123
individuals
visited
Neurological
Center,
104
confirmed
cases
were
included
digital
database.
Age-standardized
incidence
prevalence
rates
per
100,000
calculated
using
world
European
standards.
Data
analysis
performed
IBM
SPSS
Statistics
27.
Results:
The
mean
diagnostic
age
36.31±6.93
years,
higher
than
countrywide
average
34.9
years.
delay
7.01
significantly
longer
national
5.2
Regional
10.96/100,000,
with
urban
but
no
significant
sex
difference.
10-years
0.94±0.32/100,000.
Compared
neighboring
regions,
such
as
Iran’s
East
Azerbaijan
Province
Turkiye,
area
is
lower.
Although
are
below
levels,
they
exceed
those
some
Asian
countries.
Conclusion:
first
on
epidemiology
Southern
Azerbaijan.
findings
underscore
need
for
public
awareness
campaigns
enhanced
training
healthcare
professionals,
particularly
primary
care,
facilitate
early
symptom
detection
reduce
delays.
Further
research
recommended
regional
factors
affecting
diagnosis
improve
timely
access.
doi:
https://doi.org/10.12669/pjms.41.2.11373
How
cite
this:
Aliyev
RR,
Mehtiyeva
ShN,
Shiraliyeva
RK.
Clinical
epidemiological
Pak
J
Med
Sci.
2025;41(2):437-442.
an
Open
Access
article
distributed
terms
Creative
Commons
Attribution
License
(http://creativecommons.org/licenses/by/3.0),
permits
unrestricted
use,
distribution,
reproduction
any
medium,
provided
original
work
properly
cited.
S S Korsakov Journal of Neurology and Psychiatry,
Год журнала:
2025,
Номер
125(1), С. 119 - 119
Опубликована: Фев. 11, 2025
Objective.
To
study
the
dynamics
of
epidemiological
characteristics
multiple
sclerosis
(MS)
from
01.01.2003
to
01.01.2024
in
Novosibirsk
comparison
with
previous
20-year
study.
Material
and
methods.
The
prevalence
cohort
included
2254
patients
MS
living
on
01.01.2024.
cases
1998
onset
disease
31.12.2023
inclusive.
In
order
level
out
influence
heterogeneous
sex
age
composition
population
Novosibirsk,
method
standardization
indicators
was
used
(standard
European
population,
13.07.2013).
results
our
analysis
were
compared
city
(Malkova
N.A.,
2005).
Results.
as
calculated
137.83
per
100
thousand
(standardized
indicator
—
123.43).
average
46.146±0.479
years.
ratio
men
women
1:2.1.
incidence
2003
2023
shows
a
trend
toward
an
increase
(5.12±0.0662
7.71±0.0246
population/year
(p<0.05),
which
is
mainly
due
significant
proportion
(6.56±0.1118
11.01±0.091
population/year,
p<0.05),
but
not
(p>0.05).
increased
by
0.146
years
annually
during
period
amounted
30.479±0.329
(rxy=0.08,
p<0.001).
An
early-onset
late-onset
also
noted
(rxy=0.45,
p=0.041
rxy=0.622,
p=0.003,
respectively).
A
decrease
«onset—diagnosis»
interval
recorded
(mean
5.28±6.41
01.01.2003;
mean
1.77±0.921
01.01.2024).
Conclusions.
era
controlled
progression,
showed
(54.4
population).
does
demonstrate
global
3—4-fold
women.
(p<0.05).
has
significantly
over
(27.73±0.6
2003;
2023).
separate
towards
shown
part,
associated
improved
diagnostic
criteria
health
care
services.
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(10), С. 5313 - 5313
Опубликована: Май 18, 2021
Dopamine
is
a
neurotransmitter
that
mediates
neuropsychological
functions
of
the
central
nervous
system
(CNS).
Recent
studies
have
shown
modulatory
effect
dopamine
on
cells
innate
and
adaptive
immune
systems,
including
Th17
cells,
which
play
critical
role
in
inflammatory
diseases
CNS.
This
article
reviews
literature
data
regulation
neuroinflammation
multiple
sclerosis
(MS).
The
influence
dopaminergic
receptor
targeting
experimental
autoimmune
encephalomyelitis
(EAE)
MS
pathogenesis,
as
well
therapeutic
potential
drugs
add-on
pathogenetic
therapy
MS,
discussed.
Neurological Research,
Год журнала:
2021,
Номер
44(1), С. 14 - 23
Опубликована: Авг. 19, 2021
Objectives
Multiple
sclerosis
(MS)
is
a
progressive
demyelinating
and
degenerative
disease
of
the
CNS,
which
highly
variable
geographically.
The
objectives
are
to
establish
comprehensive
nationwide
MS
epidemiological
data
compare
it
with
similar
studies
conducted
in
regional
international
communities.
To
best
our
knowledge,
this
first
study
Iraq.Methods
This
retrospective
including
4355
cases
from
10
officially
authorized
clinics
Iraq
January
2000
December
2018.
All
were
diagnosed
according
McDonald's
criteria
2010,
new
patients'
records
reviewed
by
scientific
committee.Results
Our
found
that
68.51%
females
female-to-male
ratio
2.18:1
4.07%
patients
before
they
reached
18
years
age.
mean
age
was
32.3
±
9.8.
prevalence
be
11.73/100,000;
16.2/100,000
among
7.3/100,000
males.
incidence
0.05
year
1.5
2017.
Initial
symptoms
visual
32.06%,
motor
28.11%,
25.58%
sensory
symptoms,
89.97%
clinical
form
relapsing/remitting
(RRMS)
81.65%
on
first-line
treatment.
Meanwhile,
66.97%
within
weeks
or
months
symptom
onset.
Summer
had
most
frequencies
regarding
birth
season.Conclusions
has
significantly
increased
Iraq,
while
low
compared
neighboring
countries.
RRMS
common
showed
highest
frequency
presenting
symptoms.
