Neurodegenerative Disease Management,
Год журнала:
2024,
Номер
unknown, С. 1 - 17
Опубликована: Сен. 30, 2024
Deep
brain
stimulation
(DBS)
has
been
established
as
an
effective
neuromodulatory
treatment
for
Parkinson's
disease
(PD)
with
motor
complications
or
refractory
tremor.
Various
DBS
devices
unique
technology
platforms
are
commercially
available
and
deliver
continuous,
open-loop
stimulation.
The
Percept™
family
of
neurostimulators
use
BrainSense™
five
key
features
to
sense
local
field
potentials
while
stimulating,
enabling
integration
physiologic
data
into
the
routine
practice
programming.
newly
approved
rechargeable
RC
implantable
pulse
generator
offers
a
smaller,
thinner
design
reduced
recharge
time
prolonged
interval.
In
this
review,
we
describe
application
potential
sensing-based
programming
in
PD
highlight
future
clinical
implementation
closed-loop
using
generator.
Frontiers in Human Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Фев. 21, 2024
The
Deep
Brain
Stimulation
(DBS)
Think
Tank
XI
was
held
on
August
9–11,
2023
in
Gainesville,
Florida
with
the
theme
of
“Pushing
Forefront
Neuromodulation”.
keynote
speaker
Dr.
Nico
Dosenbach
from
Washington
University
St.
Louis,
Missouri.
He
presented
his
research
recently
published
Nature
inn
a
collaboration
Evan
Gordon
to
identify
and
characterize
somato-cognitive
action
network
(SCAN),
which
has
redefined
motor
homunculus
led
new
hypotheses
about
integrative
networks
underpinning
therapeutic
DBS.
DBS
founded
2012
provides
an
open
platform
where
clinicians,
engineers,
researchers
(from
industry
academia)
can
freely
discuss
current
emerging
technologies,
as
well
logistical
ethical
issues
facing
field.
group
estimated
that
globally
more
than
263,000
devices
have
been
implanted
for
neurological
neuropsychiatric
disorders.
This
year's
meeting
focused
advances
following
areas:
cutting-edge
translational
neuromodulation,
physiology,
neuromodulation
Europe
Asia,
neuroethical
dilemmas,
artificial
intelligence
computational
modeling,
time
scales
mood
disorders,
future
devices.
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Март 19, 2025
Transcranial
ultrasound
stimulation
(TUS)
offers
precise,
non-invasive
neuromodulation,
though
its
impact
on
human
deep
brain
structures
remains
underexplored.
Here
we
examined
TUS-induced
changes
in
the
basal
ganglia
of
10
individuals
with
movement
disorders
(Parkinson's
disease
and
dystonia)
15
healthy
participants.
Local
field
potentials
were
recorded
using
(DBS)
leads
globus
pallidus
internus
(GPi).
Compared
to
sham,
theta
burst
TUS
(tbTUS)
increased
power
during
stimulation,
while
Hz
enhanced
beta
power,
effects
lasting
up
40
min.
In
participants,
a
stop-signal
task
assessed
tbTUS
GPi,
pulvinar
serving
as
an
active
sham.
GPi
prolonged
reaction
times,
indicating
impaired
response
inhibition,
whereas
had
no
effect.
These
findings
provide
direct
electrophysiological
evidence
target
engagement
specificity
structures,
suggesting
potential
noninvasive
DBS
strategy
for
neurological
psychiatric
disorders.
is
method
modulate
activity.
Using
recordings
from
implanted
electrodes,
showed
that
engages
internus,
neural
oscillations
behavior.
Epilepsia,
Год журнала:
2023,
Номер
64(11), С. 3025 - 3035
Опубликована: Авг. 22, 2023
Thalamic
deep
brain
stimulation
(DBS)
is
an
effective
therapeutic
option
in
patients
with
drug-resistant
epilepsy.
Recent
DBS
devices
sensing
capabilities
enable
chronic,
outpatient
local
field
potential
(LFP)
recordings.
Whereas
beta
oscillations
have
been
demonstrated
to
be
a
useful
biomarker
movement
disorders,
the
clinical
utility
of
epilepsy
remains
unclear.
Our
aim
was
determine
LFP
features
that
distinguish
ictal
from
inter-ictal
states,
which
may
aid
tracking
seizure
outcomes
DBS.Electrophysiology
data
were
obtained
implanted
anterior
nucleus
(N
=
12)
or
centromedian
2)
thalamus.
Power
spectra
recorded
during
patient/caregiver-marked
events
analyzed
method
quantitatively
separates
oscillatory
and
non-oscillatory/aperiodic
components
using
non-parametric
statistics,
without
need
for
pre-specification
frequency
bands
interest.
Features
parameterized
this
algorithm
compared
those
power
clinic.Oscillatory
activity
multiple
canonical
identified
86.48%
patient-marked
events.
Delta
present
all
patients,
followed
by
theta
10)
9).
Although
there
no
differences
between
steeper
decline
1/f
slope
aperiodic
component
seizures.Our
work
highlights
shortcomings
chronic
recordings
thalamic
Findings
suggest
single
band
isolation
clearly
differentiates
seizures,
clinically-relevant
biomarkers
seizures.
Deep Brain Stimulation,
Год журнала:
2023,
Номер
2, С. 1 - 5
Опубликована: Май 16, 2023
ObjectivesParkinson
patients
with
chronic
DBS
routinely
receive
sensing-enabled
implantable
pulse
generators
upon
battery
replacement.
Here
we
aimed
to
assess
whether
and/or
how
local
field
potential
based
reprogramming
may
be
of
use
in
this
population.MethodsIn
four
Parkinson
on
treatment
bilateral
STN-DBS
and
implanted
the
Percept™
PC
generator,
employed
an
approach
select
stimulation
contacts
amplitudes
beta-activity.
When
applicable,
effect
parameter
adjustments
effectiveness
DBS-induced
side
effects
was
assessed.ResultsIn
one
out
eight
electrodes,
LFP-guided
contact
different
from
clinically
determined
one.
Beta-based
therapeutic
windows
could
defined
five
electrodes.
were
performed
two
patients,
resulting
improved
motor
fluctuations
decreased
stimulation-induced
respectively.DiscussionLFP-guided
has
improve
decrease
selected
cases.
Prospective
controlled
research
is
required
clinical
usefulness
reprogramming.
Journal of Neuroscience,
Год журнала:
2023,
Номер
43(45), С. 7575 - 7586
Опубликована: Ноя. 8, 2023
Deep
brain
stimulation
(DBS)
is
an
effective
therapy
for
various
neurologic
and
neuropsychiatric
disorders,
involving
chronic
implantation
of
electrodes
into
target
regions
electrical
delivery.
Despite
its
safety
efficacy,
DBS
remains
underutilized
therapy.
Advances
in
the
field
DBS,
including
technology,
mechanistic
understanding,
applications
have
potential
to
expand
access
use
while
also
improving
clinical
outcomes.
Developments
such
as
MRI
compatibility
bidirectional
systems
capable
sensing
neural
activity
providing
therapeutic
stimulation,
enabled
advances
our
understanding
mechanisms
application.
In
this
review,
we
summarize
recent
work
exploring
modulation
networks.
We
cover
current
focusing
on
improved
programming
development
novel
paradigms
that
go
beyond
standards
many
which
are
by
sensing-enabled
DBS.
Brain Sciences,
Год журнала:
2025,
Номер
15(2), С. 116 - 116
Опубликована: Янв. 25, 2025
Background/Objections:
The
pharmacological
management
of
Parkinson’s
Disease
(PD)
is
often
supplemented
by
deep
brain
stimulation
(DBS)
to
tackle
problems
advanced
disease
such
as
motor
fluctuation,
dyskinesias
or
medication-resistant
tremor.
DBS
uses
high-frequency
with
spatially
distributed
electrodes
produce
electrical
fields
that
influence
neuronal
networks.
programming
complex
and
time-consuming.
Recent
technological
advancements
have
enabled
systems
record
local
field
potentials
(LFPs).
In
conjunction
biomarker
discovery,
beta
oscillations,
this
shows
promise
in
streamlining
the
process.
This
review
aims
synthesize
current
literature
investigating
LFP
characteristics
PD
order
understand
place
LFPs
assisting
programming.
Methods:
A
comprehensive
search
was
conducted
using
databases
including
OVID
MEDLINE,
Scopus,
Cochrane
Library,
resulting
738
identified
articles;
122
studies
remained
after
screening
87
were
selected
for
detailed
analysis.
Results:
Analyzing
clearly
has
potential
assist
streamline
clinical
practice,
but
there
are
knowledge
gaps
challenges
overcome,
especially
utilization
intraoperative
LFPs.
Conclusions:
More
research
required
compare
different
algorithms
utilize
identify
a
simple,
practical
time-saving
algorithm
incorporating
reliable
biomarkers
will
enhance
experience
both
patients
clinicians.
