Journal of Anesthesia,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 4, 2024
Abstract
Purpose
Postoperative
delirium
(POD)
in
patients
with
obstructive
sleep
apnea
(OSA)
is
associated
increased
mortality
and
healthcare
costs.
In
this
study,
we
investigated
the
association
of
OSA
risk,
serum
biomarkers
for
central
nervous
ischemia
(S100B
NSE),
POD.
Methods
After
research
ethics
approval,
completed
STOP
BANG
assessment
before
undergoing
elective
surgery.
Blood
was
drawn
S100B
NSE
measurement,
cognitive
performance
tested
using
Montreal
Cognitive
Assessment
(MoCA)
at
study
admission
postoperatively
discharge.
Delirium
performed
Nursing
Screening
Scale
(NuDESC)
Confusion
Method
(CAM).
Results
One
hundred
twenty-four
enrolled
were
separated
into
three
OSA-risk
groups
based
on
score
testing
(low
n
=
22;
intermediate
67;
high
35).
Preoperative
values
risk
(NSE
ng/ml;
mean
[range];
low
risk:
15.6
[9.2–44.3];
21.8
[7.6–114.1];
29.2
[10.1–151];
p
0.039).
MoCA
NuDESC
assessments
not
different
between
groups.
We
found
a
decreasing
incidence
POD
increasing
(positive
CAM:
18.1%,
12.0%;
11.5%,
0.043).
However,
no
longer
detectable
complete
case
analysis.
POD,
postoperative
ischemic
biomarker
Conclusion
trend
which
robust
Our
results
possibly
support
phenomenon
hypoxic
preconditioning.
High Altitude Medicine & Biology,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 10, 2024
Many
Andean
highlanders
exposed
to
chronic
hypoxemia
are
susceptible
excessive
erythrocytosis
(EE)
and
mountain
sickness
(CMS).
Nocturnal
is
more
marked
than
diurnal
includes
sustained
intermittent
components.
The
potential
for
cognitive
impairments
related
nocturnal
in
this
population
has
not
been
extensively
studied,
but
improved
understanding
may
provide
opportunities
the
prevention
of
long-term
effects
EE
CMS.
PubMed,
Год журнала:
2023,
Номер
48(10), С. 1464 - 1478
Опубликована: Окт. 28, 2023
The
plateau
is
a
special
environment
with
low
pressure,
oxygen,
temperature,
and
high
ultraviolet
radiation.
exercise
performance
of
people
on
the
generally
reduced,
which
seriously
affects
life
health
living
in
entering
plateau.
In
recent
years,
prevention
treatment
injury
caused
by
altitude
hypoxia
has
attracted
wide
attention.
It
shown
that
higher
longer
duration
exercise,
faster
stationing,
greater
impact
people's
sports
performance.
Rapid
entry
into
long-term
stay
have
an
explosive
power,
endurance
fine
operation.
Advances
medical
technology
enable
various
methods
to
be
used
acclimate
environments.
However,
vitro
intervention
are
costly,
easy
rebound
possess
limited
effects.
Therefore,
drug
obviously
more
economical
choice.
Chemical
drugs
increase
efficiency
improving
ischemic
hypoxic
symptoms
heart
brain,
increasing
lung
ventilation
arterial
oxygenation
capacity,
accelerating
elimination
adverse
product
accumulation
after
exercise.
Single
Chinese
medicine,
patent
compound
preparations
can
improve
promoting
body
metabolism,
muscle
endurance,
enhancing
immunity,
other
mechanisms.
Traditional
medicine
unique
advantage
application
prospect
damage.
High Altitude Medicine & Biology,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 9, 2024
Gstir,
Claudia,
Timo
Schurr,
Roxana
Ehlers,
Johannes
Burtscher,
Barbara
Sperner-Unterweger,
and
Katharina
Hüfner.
Is
it
possible
for
individuals
with
pre-existing
mental
disorders
to
perform
mountain
sports
at
high
altitude-First
evidence
from
a
pilot
cross-sectional
questionnaire
study.
Journal Archives of Health,
Год журнала:
2024,
Номер
5(3), С. e2034 - e2034
Опубликована: Июль 30, 2024
Introdução:
Este
artigo
revisa
os
efeitos
da
exposição
à
altitude
sobre
aspectos
neuropsicológicos,
abordando
impactos
cognitivos
e
comportamentais
observados
em
indivíduos
expostos
a
diferentes
altitudes.
A
pesquisa
visa
consolidar
o
conhecimento
atual
identificar
lacunas
na
literatura
este
tema.
Materiais,
Sujeitos
Métodos:
Foram
revisados
estudos
publicados
bases
de
dados
científicas
utilizando
palavras-chave
relacionadas
neuropsicológicos.
Os
critérios
inclusão
selecionaram
que
investigaram
tanto
saudáveis
quanto
pacientes
com
condições
clínicas
específicas
altitudes
ao
redor
do
mundo.
Resultados
Discussão:
resultados
destacam
uma
variedade
neuropsicológicos
associados
altitude,
incluindo
alterações
função
cognitiva,
humor
desempenho
psicomotor.
As
discussões
abordam
mecanismos
fisiológicos
subjacentes,
como
hipoxemia
perfusão
cerebral,
podem
explicar
esses
efeitos.
Além
disso,
são
discutidas
as
implicações
práticas
desses
achados,
adaptações
ambientais
intervenções
terapêuticas
potenciais.
Considerações
Finais:
estudo
destaca
complexidade
dos
necessidade
abordagens
integradas
prática
clínica.
São
sugeridas
direções
futuras
para
pesquisa,
longitudinais
mitigar
adversos
observados.
Conclui-se
compreensão
mais
aprofundada
é
crucial
otimizar
saúde
populações
expostas
Journal of Anesthesia,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 4, 2024
Abstract
Purpose
Postoperative
delirium
(POD)
in
patients
with
obstructive
sleep
apnea
(OSA)
is
associated
increased
mortality
and
healthcare
costs.
In
this
study,
we
investigated
the
association
of
OSA
risk,
serum
biomarkers
for
central
nervous
ischemia
(S100B
NSE),
POD.
Methods
After
research
ethics
approval,
completed
STOP
BANG
assessment
before
undergoing
elective
surgery.
Blood
was
drawn
S100B
NSE
measurement,
cognitive
performance
tested
using
Montreal
Cognitive
Assessment
(MoCA)
at
study
admission
postoperatively
discharge.
Delirium
performed
Nursing
Screening
Scale
(NuDESC)
Confusion
Method
(CAM).
Results
One
hundred
twenty-four
enrolled
were
separated
into
three
OSA-risk
groups
based
on
score
testing
(low
n
=
22;
intermediate
67;
high
35).
Preoperative
values
risk
(NSE
ng/ml;
mean
[range];
low
risk:
15.6
[9.2–44.3];
21.8
[7.6–114.1];
29.2
[10.1–151];
p
0.039).
MoCA
NuDESC
assessments
not
different
between
groups.
We
found
a
decreasing
incidence
POD
increasing
(positive
CAM:
18.1%,
12.0%;
11.5%,
0.043).
However,
no
longer
detectable
complete
case
analysis.
POD,
postoperative
ischemic
biomarker
Conclusion
trend
which
robust
Our
results
possibly
support
phenomenon
hypoxic
preconditioning.
