Prolactin in sleep and EEG regulation: new mechanisms and sleep-related brain targets complement classical data
Neuroscience & Biobehavioral Reviews,
Год журнала:
2025,
Номер
unknown, С. 106000 - 106000
Опубликована: Янв. 1, 2025
The
role
of
prolactin
in
sleep
regulation
has
been
the
subject
extensive
research
over
past
50
years,
resulting
identification
multiple,
disparate
functions
for
hormone.
Prolactin
demonstrated
a
characteristic
circadian
release
pattern
with
elevation
during
dark
and
diminution
light.
High
levels
were
linked
to
non-rapid
eye
movement
electroencephalogram
delta
activity
humans.
Conversely,
hyperprolactinemia
showed
strong
correlation
REM
rodent
studies.
may
be
implicated
alterations
female
patterns
observed
reproductive
cycle,
it
play
enhancement
following
stress
sleep-related
immunological
processes.
In
conclusion,
appears
have
sleep-promoting
role,
particularly
phase.
However,
does
not
appear
central
coherent
regulation,
as
some
neuropeptides
such
orexin.
its
principal
function
facilitate
situational,
yet
adaptive,
changes
response
challenging
physiological
phases,
those
associated
stress,
challenges,
or
cycle.
Neuronal
substrates
prolactin-mediated
effects
remain
unknown;
however,
recent
studies
provide
insights
into
potential
sites
these
effects.
Язык: Английский
Sleep Disorders: Pathogenesis and Therapeutic Interventions
Cheng Liu,
Zhigang He,
Yanqiong Wu
и другие.
MedComm,
Год журнала:
2025,
Номер
6(3)
Опубликована: Март 1, 2025
Sleep
disorder
significantly
disrupts
the
quality
of
life
for
patients.
Although
it
is
clinically
acknowledged,
fundamental
neuropathological
mechanisms
are
still
not
understood.
Recent
preclinical
research
has
been
directed
toward
understanding
underlying
sleep
deprivation
and
sleep/wake
dysregulation.
linked
to
changes
in
structure
function
neural
basis
cognition.
We
reviewed
circuits
related
disorders,
along
with
alterations
connectivity
brain
region
functions,
based
on
advancements
electrophysiology
optogenetic/chemogenetic
techniques.
subsequently
outline
cellular
molecular
modifications
disorders
studies,
primarily
involving
neuronal
metabolism,
electrophysiological
activity,
synaptic
plasticity,
glial
cells.
Correspondingly,
crosstalk
between
peripheral
organs,
we
elucidate
involvement
celiac
disease
hepatic
pathogenesis
disorders.
In
this
review,
mainly
discussed
at
molecular,
cellular,
circuit
levels
that
contribute
disorder.
The
review
also
covered
potential
strategies
treating
future
avenues.
Язык: Английский
Noradrenaline enhances Na‐K ATPase subunit expression by HuR‐induced mRNA stabilization and their transportation to the cell surface through PLC and PKC mediated pathway: Implications with REMS‐loss associated disorders
Journal of Neurochemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 26, 2024
Rapid
eye
movement
sleep
(REMS)
maintains
brain
excitability
at
least
by
regulating
Na-K
ATPase
activity.
Although
REMS
deprivation
(REMSD)-associated
elevated
noradrenaline
(NA)
increases
protein
expression,
its
mRNA
transcription
did
not
increase.
We
hypothesized
and
confirmed
both
in
vivo
as
well
vitro
that
stability
explains
the
apparent
puzzle.
The
was
measured
control
REMSD
rat
with
or
without
treatment
α
Язык: Английский