Developing Non-Invasive Molecular Markers for Early Risk Assessment of Alzheimer's Disease
Biomarkers in Neuropsychiatry,
Год журнала:
2025,
Номер
unknown, С. 100120 - 100120
Опубликована: Янв. 1, 2025
Язык: Английский
Regional brain structural alterations in reward and salience networks in asthma
Brain Behavior and Immunity,
Год журнала:
2025,
Номер
126, С. 80 - 97
Опубликована: Фев. 5, 2025
Язык: Английский
RhoA/ROCK/GSK3β Signaling: A Keystone in Understanding Alzheimer’s Disease
Current Issues in Molecular Biology,
Год журнала:
2025,
Номер
47(2), С. 124 - 124
Опубликована: Фев. 14, 2025
Alzheimer's
disease
(AD)
is
a
neurodegenerative
characterized
by
progressive
cognitive
decline
and
loss
of
neuronal
integrity.
Emerging
evidence
suggests
that
RhoA,
Rho-associated
coiled-coil
kinase
(ROCK),
their
downstream
effector
molecule
glycogen
synthase
3β
(GSK3β)
interact
within
complex
signaling
pathway
(RhoA/ROCK/GSK3β)
plays
crucial
role
in
the
pathogenesis
AD.
small
GTPase,
along
with
its
effector,
ROCK,
regulates
various
cellular
processes,
including
actin
cytoskeleton
dynamics,
apoptosis,
synaptic
plasticity.
GSK3β,
serine/threonine
kinase,
key
function
AD
pathology,
regulation
tau
phosphorylation
amyloid-beta
cleavage.
Overactive
GSK3β
has
been
closely
linked
to
hyperphosphorylation,
neurodegeneration,
progression
Thus,
considered
as
promising
therapeutic
target
for
treating
mitigating
impairment.
However,
clinical
trials
have
faced
considerable
challenges
due
complexity
specific
inhibition
GSK3β.
In
this
review,
we
summarize
literature
regarding
relationship
RhoA/ROCK
pathways
pathogenesis.
We
further
discuss
recent
findings
sTREM2-transgelin-2
(TG2)
axis
potential
mediator
provide
our
review
on
novel
targeting
strategy
Язык: Английский
The Neuroimmune Axis in Gastrointestinal Disorders – An Underrecognized Problem
Current Gastroenterology Reports,
Год журнала:
2025,
Номер
27(1)
Опубликована: Апрель 15, 2025
Язык: Английский
Association between air quality and neurodegenerative diseases in River Sacco Valley: A retrospective cohort study in Latium, central Italy
International Journal of Hygiene and Environmental Health,
Год журнала:
2025,
Номер
267, С. 114578 - 114578
Опубликована: Апрель 16, 2025
Язык: Английский
Evaluating the Cost-Effectiveness of Pharmacological Therapy in Alzheimer Disease in Brazil
Value in Health Regional Issues,
Год журнала:
2025,
Номер
49, С. 101130 - 101130
Опубликована: Май 27, 2025
Язык: Английский
Cholinesterase inhibitor use in amyloid PET-negative mild cognitive impairment and cognitive changes
Alzheimer s Research & Therapy,
Год журнала:
2024,
Номер
16(1)
Опубликована: Окт. 2, 2024
Язык: Английский
Overlapping Receptor-Based Pathogenic Cascades in Degenerative Disease: Implications Ranging from Tumor Targeting to Aging and Dementia Therapeutics
International Journal of Translational Medicine,
Год журнала:
2024,
Номер
4(1), С. 152 - 162
Опубликована: Фев. 6, 2024
Previous
research
has
already
shown
that
apolipoprotein
(apo)A-I
is
adsorbed
from
the
bloodstream
onto
surface
of
certain
colloidal
lipid
particles
after
intravenous
injection
such
nanocarriers.
As
a
result,
various
blood–brain
barrier
(BBB)
scavenger
receptors
are
targeted
by
these
(apoA-I-coated)
This
molecular
interaction
mediated/facilitated
apoA-I,
which
then
followed
receptor-mediated
endocytosis
and
subsequent
transcytosis
nanocarrier
across
BBB.
A
multifunctional
combination
therapy
obtained
adding
appropriate
drug(s)
to
biomimetic
(lipid
cubic
phase)
therapeutic
targets
specific
cell-surface
receptors,
primarily
class
B
type
I
(SR-BI),
crosses
barrier.
The
contents
artificial
(nanoemulsion)
naturally
occurring
high-density
lipoproteins
(HDL)
have
been
be
similar,
enables
partially
imitate
or
simulate
known
heterogeneity
(i.e.,
subpopulations
subspecies)
HDL
particles.
Hence,
drug
nanocarriers
potential
used
in
biomedical
treatment
complicated
medical
conditions
including
dementia,
as
well
elements
aging.
Widespread
inflammation
oxidative
stress—two
processes
include
several
pathophysiological
cascades—are
brought
on
dementia
risk
factors.
More
recent
studies
suggest
proinflammatory
cytokines
may
released
response
prolonged
inflammatory
stimulus
gut,
for
example
through
serum
amyloid
(SAA).
Therefore,
pharmacologically
targeting
major
SAA
receptor
implicated
SAA-mediated
cell
signaling
cause
aging
and/or
cognitive
decline,
ultimately
Alzheimer’s
disease
(late-onset)
could
an
effective
preventive
approach.
Язык: Английский