Deep brain stimulation of the amygdala for treatment-resistant combat post-traumatic stress disorder: Long-term results
Ralph J. Koek,
Josué M. Avecillas-Chasín,
Scott E. Krahl
и другие.
Journal of Psychiatric Research,
Год журнала:
2024,
Номер
175, С. 131 - 139
Опубликована: Май 3, 2024
Deep
brain
stimulation
(DBS)
holds
promise
for
neuropsychiatric
conditions
where
imbalance
in
network
activity
contributes
to
symptoms.
Treatment-resistant
Combat
post-traumatic
stress
disorder
(TR-PTSD)
is
a
highly
morbid
condition
and
50%
of
PTSD
sufferers
fail
recover
despite
psychotherapy
or
pharmacotherapy.
Reminder-triggered
symptoms
may
arise
from
inadequate
top-down
ventromedial
prefrontal
cortex
(vmPFC)
control
amygdala
reactivity.
Here,
we
report
long-term
data
on
two
TR-PTSD
participants
an
investigation
utilizing
high-frequency
DBS.
The
combat
veterans
were
implanted
bilaterally
with
quadripolar
electrodes
targeting
the
basolateral
amygdala.
Following
randomized
staggered
onset,
patients
received
adjustments
based
symptom
severity
four
years
while
psychiatric
symptoms,
neuropsychological
performance,
electroencephalography
systematically
monitored.
Evaluation
vmPFC-Amygdala
engagement
was
assessed
Язык: Английский
Biological treatments for co-occurring eating disorders and psychological trauma: a systematic review
Frontiers in Psychiatry,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 21, 2025
Introduction
Many
people
with
eating
disorders
report
having
experienced
childhood
maltreatment
or
a
traumatic
event
prior
to
developing
an
disorder.
Although
many
have
significant
exposure
symptoms
of
post-traumatic
stress
disorder,
very
little
research
has
examined
the
effects
combined
treatments
for
this
group.
The
purpose
systematic
review
was
synthesize
all
existing
on
biological
those
and
psychological
trauma,
evaluate
their
safety,
identify
future
areas
in
area
support
patients
trauma.
Method
A
multi-step
literature
search,
according
priori
protocol
performed
PubMed,
Embase,
APA
PsycINFO,
Web
Science,
Scopus
Cochrane
Central.
Studies
needed
include
intervention
at
least
one
disorder
trauma
outcome.
Given
limited
area,
minimal
exclusion
criteria
were
applied.
quality
assessment
included
studies
completed
using
Risk
Bias
Non-Randomized
Studies-or
Interventions
(ROBINS-I)
tool.
Results
After
removing
duplicates,
2623
article
titles
abstracts
screened,
43
articles
selected
full-text
review.
Following
review,
11
met
inclusion
criteria.
repurposed
medications
(n
=
3),
ketamine
2),
repetitive
transcranial
magnetic
stimulation
(rTMS;
n
deep
brain
=1)
electroconvulsive
therapy
(ECT;
1),
3,4-methylenedioxymethamphetamine
(MDMA;
neurofeedback
1).
All
reported
some
improvement
either
pathology,
strongest
effect
MDMA.
While
promising,
missing
data
selective
reporting
interpretability
findings.
Adverse
events
across
interventions
common.
Conclusion
is
common
disorders,
few
been
evaluated
population.
Future
work
should
aim
investigate
co-occurring
as
these
evolving
show
potential
benefits
complex
Язык: Английский
Comparison between Single-Dose and Two-Dose Psilocybin Administration in the Treatment of Major Depression: A Systematic Review and Meta-Analysis of Current Clinical Trials
Brain Sciences,
Год журнала:
2024,
Номер
14(8), С. 829 - 829
Опубликована: Авг. 18, 2024
Current
pharmacological
treatments
for
major
depressive
disorder
(MDD)
are
often
only
partially
effective,
with
many
patients
experiencing
no
significant
benefit,
leading
to
treatment-resistant
depression
(TRD).
Psilocybin,
a
classical
serotonergic
psychedelic,
has
emerged
as
notable
emerging
treatment
such
disorders.
The
aim
of
this
systematic
review
and
meta-analysis
is
summarize
discuss
the
most
recent
evidence
about
therapeutic
effects
single-dose
two-dose
psilocybin
administration
on
severity
symptoms,
well
compare
efficacy
these
interventions
among
primary
diagnosis
MDD
or
TRD.
Articles
were
collected
from
EBSCOhost
PubMed
following
PRISMA
guidelines,
yielding
425
articles
138
duplicates.
After
screening
287
records,
12
studies
met
eligibility
criteria
included
in
review.
A
quantitative
analysis
indicates
that
highly
effective
reducing
symptoms
Both
significantly
reduced
severity,
sometimes
more
pronounced
lasting
effects.
However,
it
unclear
if
was
solely
due
dosage
other
factors.
Future
research
should
include
standardized
trials
comparing
dosing
strategies
better
inform
clinical
practice.
Язык: Английский
PTSD Treatment Literature
European Journal of Medical and Health Research,
Год журнала:
2024,
Номер
2(5), С. 4 - 9
Опубликована: Сен. 1, 2024
PTSD
cases
represents
a
growing
expense
for
society
and
the
U.S.
Veterans
Administration
since
proportion
of
veterans
with
symptom
exceed
proportions
in
civilian
population.
The
literature
is
not
agreement
whether
“cure”
exists
what
would
look
like.
A
wide
variety
treatment
approaches
have
been
applied
differing
results
regarding
mitigation
symptoms
duration
mitigation.
Authoritative
sources
from
United
States,
Kingdom
Australia
identity
specific
psychotherapies
as
“gold
standard”
treatment.
Despite
warnings,
patients
prescribed
pharmacological
remedies.
In
States
only
two
drugs
approved
by
US
Food
Drug
(FDA)
However,
wider
array
has
prescribed.
Department
Veteran
Affairs
(DVA)
specifically
concluded
that
benzodiazepines
use
recommended
strategy
treatment,
yet
it
dispensed
to
veterans,
although
at
more
limited
rate
than
previously.
Knowledge
about
relative
effectiveness
alternative
treatments
still
emerging.
As
indicated
changes
guidelines,
conventional
wisdom
fluid
need
periodic
reassessment.
Research
on
new
types
should
be
ongoing.
Язык: Английский
Transcranial Magnetic Stimulation for Posttraumatic Stress Disorder and Generalized Anxiety Disorder
Samantha L. Cilli,
Miriam A Goldberg,
Camila Cosmo
и другие.
Current topics in behavioral neurosciences,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Brain Sciences Special Issue “Neuromodulation of Cortical Networks in Neurological and Neuropsychiatric Disorders: Potential Clinical Indications and the Biophysiological Impact of Stimulation”
Brain Sciences,
Год журнала:
2024,
Номер
14(5), С. 459 - 459
Опубликована: Май 1, 2024
Individuals
with
neurological
and
neuropsychiatric
disorders
face
a
variety
of
difficulties
that
can
significantly
impact
their
daily
lives
[...]
Язык: Английский
The Origin of Natural Neurostimulation: A Narrative Review of Noninvasive Brain Stimulation Techniques
OBM Neurobiology,
Год журнала:
2024,
Номер
08(04), С. 1 - 23
Опубликована: Ноя. 29, 2024
This
narrative
review
of
the
literature
on
noninvasive
brain
stimulation
techniques
observes
four
neurostimulation
domains:
light
therapy,
photobiomodulation,
a
group
within
transcranial
electric
current
and
magnetic
field
stimulations,
low-frequency
sound
including
vibroacoustic
rhythmic
auditory
stimulation.
The
aims
to
determine
whether
or
not
different
approaches
rely
upon
similar
physicochemical
sequence
actions.
study
identifies
relevant
hypotheses
about
processes
at
cellular
level
underlying
data
analysis
reveals
that
mitochondria
activity
will
likely
play
central
role
in
stimulations
implemented
by
approaches.
Additionally,
mother-fetus
neurocognitive
model
gives
insight
into
conditions
natural
fetal
nervous
system
during
pregnancy.
Drawing
these
findings,
article
supposes
hypothesis
origin
gestation.
presents
requisites
nature-based
technique,
called
Acoustic
Photonic
Intellectual
Neurostimulation
(APIN),
derived
from
studying
components.
Язык: Английский
Boosting Psychotherapy With Noninvasive Brain Stimulation: The Whys and Wherefores of Modulating Neural Plasticity to Promote Therapeutic Change
Neural Plasticity,
Год журнала:
2024,
Номер
2024(1)
Опубликована: Янв. 1, 2024
The
phenomenon
of
neural
plasticity
pertains
to
the
intrinsic
capacity
neurons
undergo
structural
and
functional
reconfiguration
through
learning
experiential
interaction
with
environment.
These
changes
could
manifest
themselves
not
only
as
a
consequence
various
life
experiences
but
also
following
therapeutic
interventions,
including
application
noninvasive
brain
stimulation
(NIBS)
psychotherapy.
As
standalone
therapies,
both
NIBS
psychotherapy
have
demonstrated
their
efficacy
in
amelioration
psychiatric
disorders’
symptoms,
certain
variability
terms
effect
sizes
duration.
Consequently,
scholars
suggested
convenience
integrating
two
interventions
into
multimodal
treatment
boost
prolong
outcomes.
Such
an
approach
is
still
its
infancy,
physiological
underpinnings
substantiating
effectiveness
utility
combined
are
be
clarified.
Therefore,
this
opinion
paper
aims
provide
theoretical
framework
consisting
compelling
arguments
why
adding
can
promote
change.
Namely,
we
will
discuss
effects
thus
providing
rationale
explain
potential
advantages
approach.
Язык: Английский