The Transorbital Approach: A Comprehensive Review of Targets, Surgical Techniques, and Multiportal Variants

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(9), С. 2712 - 2712

Опубликована: Май 5, 2024

The transorbital approach (TOA) is gaining popularity in skull base surgery scenarios. This represents a valuable surgical corridor to access various compartments and safely address several intracranial pathologies, both intradurally extradurally, including tumors of the olfactory groove anterior cranial fossa (ACF), cavernous sinus middle (MCF), cerebellopontine angle posterior (PCF). TOA exists many variants, from point view invasiveness that entry orbit, corresponding four orbital quadrants: superior eyelid crease (SLC), precaruncular (PC), lateral retrocanthal (LRC), preseptal lower (PS). Moreover, multiportal consisting combination with others, exist are relevant reach peculiar territories. significance neurosurgery, coupled dearth thorough studies assessing its applications adaptations, underscores necessity for this research. extensive review delineates multitude target lesions reachable through route, categorizing them based on complexity. Furthermore, it provides an overview different variations, standalone conjunction other techniques. By offering comprehensive understanding, study aims enhance awareness knowledge regarding current utility neurosurgery. Additionally, steer future investigations toward deeper exploration, refinement, exploration additional perspectives concerning method.

Язык: Английский

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Spontaneous Resolution of Symptomatic Synovial Cysts of the Lumbar Spine: A Comprehensive Review with Two Illustrative Cases

Medicina, Год журнала: 2024, Номер 60(7), С. 1115 - 1115

Опубликована: Июль 9, 2024

Although lumbar synovial cysts (LSCs) are frequently described in the literature, they a relatively uncommon cause of low back and radicular leg pain. Furthermore, their spontaneous resolution is an even rarer event. The standard treatment cyst surgical excision. Spontaneous literature sporadic In our experience, we have had two cases where disappeared spontaneously. To date, only nine been documented literature. this discussion, highlight pathology that typically suggests intervention, yet conservative can be viable alternative. We present large were initially scheduled for surgery but ultimately resolved spontaneously without any treatment. While extremely rare, strategies option should not overlooked. Our contribute to growing body evidence on regression symptomatic LSC, potentially enhancing understanding disease's natural progression future.

Язык: Английский

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The Complexity of Malignant Glioma Treatment

Cancers, Год журнала: 2025, Номер 17(5), С. 879 - 879

Опубликована: Март 4, 2025

Malignant glioma is a highly aggressive, therapeutically non-responsive, and deadly disease with unique tumor microenvironment (TME). Of the 14 currently recognized described cancer hallmarks, five are especially implicated in malignant targetable repurposed drugs: stem-like cells, general, cells particular (GSCs), vascularization hypoxia, metabolic reprogramming, tumor-promoting inflammation sustained proliferative signaling. Each hallmark drives development, both individually through interactions other which TME plays critical role. To combat aggressive spatio-temporal heterogeneity driven by interactions, to overcome its therapeutic challenges, combined treatment strategy including anticancer therapies, drugs multimodal immunotherapy should be aim for future approaches.

Язык: Английский

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MEASegNet: 3D U-Net with Multiple Efficient Attention for Segmentation of Brain Tumor Images

Applied Sciences, Год журнала: 2025, Номер 15(7), С. 3791 - 3791

Опубликована: Март 30, 2025

Brain tumors are a type of disease that affects people’s health and have received extensive attention. Accurate segmentation Magnetic Resonance Imaging (MRI) images for brain is essential effective treatment strategies. However, there scope enhancing the accuracy established deep learning approaches, such as 3D U-Net. In pursuit improved precision tumor MRI images, we propose MEASegNet, which incorporates multiple efficient attention mechanisms into U-Net architecture. The encoder employs Parallel Channel Spatial Attention Block (PCSAB), bottleneck layer leverages Reduce Residual Atrous Pyramid Pooling (CRRASPP) attention, decoder Selective Large Receptive Field (SLRFB). Through integration various mechanisms, enhance capacity detailed feature extraction, facilitate interplay among distinct features, ensure retention more comprehensive information. Consequently, this leads to an enhancement in images. conclusion, our experimentation on BraTS2021 dataset yields Dice scores 92.50%, 87.49%, 84.16% Whole Tumor (WT), Core (TC), Enhancing (ET), respectively. These results indicate marked improvement over conventional

Язык: Английский

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Potential Biomarkers for IDH-Mutant and IDH-Wild-Type Glioblastomas: A Single-Center Retrospective Study

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(7), С. 2518 - 2518

Опубликована: Апрель 7, 2025

Background/Objectives: Glioblastoma ranks among the most aggressive brain tumors, with poor prognosis. Currently, there are insufficient data regarding prognostic value of isocitrate dehydrogenase (IDH) mutation status and inflammatory markers. This study demonstrates IDH preoperative markers in glioblastoma. Methods: single-center retrospective encompassed 66 glioblastoma patients who had surgical treatment our institution from January 2020 to March 2022. The were categorized into two groups: IDH-mutant (n = 30) IDH-wild-type 36). We made a comparative assessment demographic characteristics, clinical parameters, blood survival outcome across groups. Statistical analyses included Kaplan-Meier curves, ROC analysis, multivariate Cox regression. Results: group demonstrated significantly lower mean age (53.93 ± 12.00) compared wild-type (62.39 10.12) (p 0.003). Median overall was notably longer group, at 16.0 months, versus 6.5 months 0.030). An elevated neutrophil/lymphocyte ratio above 3.39 (sensitivity 95.12%, specificity 52.0%) platelet/lymphocyte exceeding 136.25 80.49%, 64.0%) associated regression analysis identified (HR 2.84, 95% CI: 1.56-5.18) NLR 1.84, 1.16-2.92) as independent factors. Conclusions: show that glioblastomal have poorer In this case, metrics seem be supplied some biomarkers for expansion disease predicting likely outcomes.

Язык: Английский

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Revolutionizing Brain Tumor Care: Emerging Technologies and Strategies

Biomedicines, Год журнала: 2024, Номер 12(6), С. 1376 - 1376

Опубликована: Июнь 20, 2024

Glioblastoma multiforme (GBM) is one of the most aggressive forms brain tumor, characterized by a daunting prognosis with life expectancy hovering around 12–16 months. Despite century relentless research, only select few drugs have received approval for tumor treatment, largely due to formidable barrier posed blood–brain barrier. The current standard care involves multifaceted approach combining surgery, irradiation, and chemotherapy. However, recurrence often occurs within months despite these interventions. challenges drug delivery overcoming therapeutic resistance become focal points in treatment tumors are deemed essential recurrence. In recent years, promising wave advanced treatments has emerged, offering glimpse hope overcome limitations existing therapies. This review aims highlight cutting-edge technologies ongoing stages development, providing patients valuable insights guide their choices treatment.

Язык: Английский

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Unveiling the Molecular Mechanisms of Glioblastoma through an Integrated Network-Based Approach

Biomedicines, Год журнала: 2024, Номер 12(10), С. 2237 - 2237

Опубликована: Окт. 1, 2024

: Despite current treatments extending the lifespan of Glioblastoma (GBM) patients, average survival time is around 15-18 months, underscoring fatality GBM. This study aims to investigate impact sample heterogeneity on gene expression in GBM, identify key metabolic pathways and modules, explore potential therapeutic targets.

Язык: Английский

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MetaWise: Combined Feature Selection and Weighting Method to Link the Serum Metabolome to Treatment Response and Survival in Glioblastoma

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(20), С. 10965 - 10965

Опубликована: Окт. 11, 2024

Glioblastoma (GBM) is a highly malignant and devastating brain cancer characterized by its ability to rapidly aggressively grow, infiltrating tissue, with nearly universal recurrence after the standard of care (SOC), which comprises maximal safe resection followed chemoirradiation (CRT). The metabolic triggers leading reprogramming tumor behavior resistance are an area increasingly studied in relation molecular features associated outcome. There currently no metabolomic biomarkers for GBM. Studying alterations GBM patients undergoing CRT could uncover biochemical pathways involved response resistance, identification novel optimization treatment response. feature selection process identifies key factors improve model’s accuracy interpretability. This study utilizes combined approach, incorporating both Least Absolute Shrinkage Selection Operator (LASSO) Minimum Redundancy–Maximum Relevance (mRMR), alongside rank-based weighting method (i.e., MetaWise) link 12-month 20-month overall survival (OS) status Our shows promising results, reducing dimensionality when employed on serum-based large-scale datasets (University Florida) all our analyses. proposed successfully identified set eleven serum shared among three datasets. computational results show that utilized achieves 96.711%, 92.093%, 86.910% rates 48, 46, 33 selected CRT, 12-month, OS-based datasets, respectively. discovery has implications developing personalized plans improving patient outcomes.

Язык: Английский

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Genomic Profiling in Glioma Patients to Explore Clinically Relevant Markers

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 13004 - 13004

Опубликована: Дек. 3, 2024

Gliomas are a heterogeneous group of brain tumors, among which the most aggressive subtype is glioblastoma, accounting for 60% cases in adults. Available systemic treatment options few and ineffective, so new approaches to therapies glioblastoma high demand. In total, 131 patients with diffuse glioma were studied. Paired tumor-normal samples sequenced on Illumina platform; panel included 812 genes associated cancer development. Molecular profiles clinically distinct groups investigated. low-grade (LGG) (n = 18), common mutations

Язык: Английский

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Association of Schimmelpenning Syndrome with Astrocytoma (WHO Grade 3): Case Report

Medicina, Год журнала: 2024, Номер 60(10), С. 1688 - 1688

Опубликована: Окт. 14, 2024

Schimmelpenning syndrome, or epidermal nevus is a rare, neurocutaneous disorder characterized by skin abnormalities, such as nevi, and involvement of the central nervous system, including intracranial tumors. There are only few reported cases tumors associated with syndrome. In most cases, single nucleotide mutation in RAS family proto-oncogenes, like

Язык: Английский

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