Immunity and Coagulation in COVID-19
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(20), С. 11267 - 11267
Опубликована: Окт. 19, 2024
Discovered
in
late
2019,
the
SARS-CoV-2
coronavirus
has
caused
largest
pandemic
of
21st
century,
claiming
more
than
seven
million
lives.
In
most
cases,
COVID-19
disease
by
virus
is
relatively
mild
and
affects
only
upper
respiratory
tract;
it
often
manifests
itself
with
fever,
chills,
cough,
sore
throat,
but
also
less-common
symptoms.
patients
do
not
require
hospitalization,
fully
recover.
However,
some
infection
leads
to
development
a
severe
form
COVID-19,
which
characterized
life-threatening
complications
affecting
lungs,
other
organs
systems.
particular,
various
forms
thrombotic
are
common
among
COVID-19.
The
mechanisms
for
remain
unclear.
Accumulated
data
indicate
that
pathogenesis
based
on
disruptions
functioning
innate
immune
key
role
primary
response
viral
assigned
two
These
pattern
recognition
receptors,
primarily
members
toll-like
receptor
(TLR)
family,
complement
system.
Both
systems
first
engage
fight
against
launch
whole
range
aimed
at
its
rapid
elimination.
Normally,
their
joint
activity
destruction
pathogen
recovery.
these
can
cause
an
excessive
inflammatory
dangerous
body.
turn,
inflammation
entails
activation
damage
vascular
endothelium,
as
well
hypercoagulable
state
observed
seriously
ill
Activation
endothelium
hypercoagulation
lead
thrombosis
and,
result,
tissues.
Immune-mediated
termed
"immunothrombosis".
this
review,
we
discuss
detail
features
immunothrombosis
associated
potential
underlying
mechanisms.
Язык: Английский
Mapping of Functional Metabolic Phenotypes in Acute Myeloid Leukemia
Cancer Medicine,
Год журнала:
2025,
Номер
14(10)
Опубликована: Май 1, 2025
ABSTRACT
Background
Acute
myeloid
leukemia
(AML)
is
an
aggressive
hematologic
malignancy
with
a
poor
prognosis,
particularly
in
older
patients.
AML
highly
heterogeneous,
influenced
by
various
chromosomal,
genetic,
and
epigenetic
alterations.
Methods
This
study
investigated
the
metabolic
profiles
of
primary
cells
from
46
patients,
focusing
on
mitochondrial
respiration
glycolysis.
We
hypothesized
that
would
reflect
distinct
disease
characteristics.
Using
Seahorse
technology,
we
measured
oxygen
consumption
rate
(OCR)
for
extracellular
acidification
(ECAR)
Results
Our
results
showed
significant
variability
activity,
some
samples
relying
more
glycolysis
than
respiration.
Mature
(FAB
M4/M5,
CD34
negative)
exhibited
increased
rates
both
glycolysis,
indicating
adaptations.
Higher
glycolytic
activity
was
observed
patients
adverse
cytogenetic
abnormalities.
However,
no
clear
associations
were
found
between
mutations
FLT3
or
NPM1
.
Conclusion
These
findings
highlight
role
suggest
targeting
specific
pathways
could
offer
therapeutic
opportunities,
subgroups
like
FAB
M4/M5
unique
features.
Further
studies
are
needed
to
refine
these
strategies
clinical
application.
Язык: Английский