Oligodendrocytes use post-synaptic proteins to coordinate myelin formation on axons of distinct neurotransmitter classes DOI Creative Commons

Natalie Carey,

Caleb A. Doll, Bruce Appel

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Окт. 3, 2024

ABSTRACT Axon myelination can tune neuronal circuits through placement and modulation of different patterns myelin sheaths on distinct types axons. How formation is coordinated axon classes remains largely unknown. Recent work indicates activity vesicle release promote formation, myelin-producing oligodendrocytes express canonical postsynaptic factors that potentially facilitate oligodendrocyte-axon interaction for ensheathment. Here, we examined whether the inhibitory scaffold protein Gephyrin (Gphn) mediates selective specific in larval zebrafish. Consistent with this possibility, Gphn was enriched GABAergic glycinergic Strikingly, gphnb deficient larvae, were longer specifically axons, frequency shifted toward glutamatergic axons at expense Collectively, our results indicate use machinery to coordinate an identity-dependent manner.

Язык: Английский

Editorial for Brain Sciences Special Issue “Advances in Restorative Neurotherapeutic Technologies” DOI Creative Commons
Trenton A. Line, Isabella S. Elkinbard, David Purger

и другие.

Brain Sciences, Год журнала: 2025, Номер 15(3), С. 273 - 273

Опубликована: Март 5, 2025

From Ramon y Cajal and Golgi’s histological techniques to single-cell RNA sequencing, technological innovations have long driven progress in neuroscience [...]

Язык: Английский

Процитировано

0
Oligodendrocytes use post-synaptic proteins to coordinate myelin formation on axons of distinct neurotransmitter classes DOI Creative Commons

Natalie Carey,

Caleb A. Doll, Bruce Appel

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Окт. 3, 2024

ABSTRACT Axon myelination can tune neuronal circuits through placement and modulation of different patterns myelin sheaths on distinct types axons. How formation is coordinated axon classes remains largely unknown. Recent work indicates activity vesicle release promote formation, myelin-producing oligodendrocytes express canonical postsynaptic factors that potentially facilitate oligodendrocyte-axon interaction for ensheathment. Here, we examined whether the inhibitory scaffold protein Gephyrin (Gphn) mediates selective specific in larval zebrafish. Consistent with this possibility, Gphn was enriched GABAergic glycinergic Strikingly, gphnb deficient larvae, were longer specifically axons, frequency shifted toward glutamatergic axons at expense Collectively, our results indicate use machinery to coordinate an identity-dependent manner.

Язык: Английский

Процитировано

0