Effect of knockdown LncRNA SNHG1 on autophagic function in SH-SY5Y cells: a model of Alzheimer’s disease (AD) DOI

Xiaoxu Li,

Xu-Sheng Yan,

Chunjie Zhang

и другие.

Journal of Toxicology and Environmental Health, Год журнала: 2025, Номер unknown, С. 1 - 9

Опубликована: Март 5, 2025

Alzheimer 's disease, a neurodegenerative is considered serious global type of dementia affecting predominantly elderly associated with progressive memory loss. disease exhibits typical pathological manifestations including neuronal loss, β-amyloid deposition, and tau protein neurofibrillary tangles. Significantly increased expression long-non -coding transcript RNA, LncRNA SNHG1, was detected in the brain AD patients. However, it not clear whether knockdown SNHG1 might improve autophagy function SH-SY5Y cells reduce number apoptotic cells. The aim this study to (1) examine role on autophagic following induction by Aβ1-42 (2) elucidate underlying mechanisms. were transfected lentiviral vectors construct cell line stable genetic ability knock down compared control empty vector line. Following for 24 hr, an model constructed. Downregulation significantly viability lowered Concomitantly downregulation induced significant decrease p-tau caspase3 elevated Beclin1 AMBRA1. Our results showed that reduced enhancing Data suggest knocking may be potential target compounds treat AD.

Язык: Английский

LncRNAs Orchestrating Neuroinflammation: A Comprehensive Review DOI Creative Commons

Arash Esmaeili,

Niloufar Yazdanpanah, Nima Rezaei

и другие.

Cellular and Molecular Neurobiology, Год журнала: 2025, Номер 45(1)

Опубликована: Март 8, 2025

CNS diseases account for a major part of the comorbidity and mortality human population; moreover, neuroinflammation has become an indication different diseases, instance, Parkinson's Alzheimer's disease. Microglia astrocytes are two main glial cells that can be found in CNS. Each these plays important role mediating immune responses like inflammation. There many studies suggesting LncRNAs neuroinflammation. Indeed, orchestrate through various mechanisms, namely miRNA sponge, transcriptional activation/inhibition. In addition, regulate downstream pathways NF-κB, PI3K/AKT. this study, we gathered existing regarding mechanisms action pathogenesis neurodegenerative traumatic injuries regulating We aim to elaborate on regulatory roles bring more profound understanding etiology terms

Язык: Английский

Процитировано

0
Effect of knockdown LncRNA SNHG1 on autophagic function in SH-SY5Y cells: a model of Alzheimer’s disease (AD) DOI

Xiaoxu Li,

Xu-Sheng Yan,

Chunjie Zhang

и другие.

Journal of Toxicology and Environmental Health, Год журнала: 2025, Номер unknown, С. 1 - 9

Опубликована: Март 5, 2025

Alzheimer 's disease, a neurodegenerative is considered serious global type of dementia affecting predominantly elderly associated with progressive memory loss. disease exhibits typical pathological manifestations including neuronal loss, β-amyloid deposition, and tau protein neurofibrillary tangles. Significantly increased expression long-non -coding transcript RNA, LncRNA SNHG1, was detected in the brain AD patients. However, it not clear whether knockdown SNHG1 might improve autophagy function SH-SY5Y cells reduce number apoptotic cells. The aim this study to (1) examine role on autophagic following induction by Aβ1-42 (2) elucidate underlying mechanisms. were transfected lentiviral vectors construct cell line stable genetic ability knock down compared control empty vector line. Following for 24 hr, an model constructed. Downregulation significantly viability lowered Concomitantly downregulation induced significant decrease p-tau caspase3 elevated Beclin1 AMBRA1. Our results showed that reduced enhancing Data suggest knocking may be potential target compounds treat AD.

Язык: Английский

Процитировано

0