Neurobiological and Microbiota Alterations After Bariatric Surgery: Implications for Hunger, Appetite, Taste, and Long-Term Metabolic Health
Brain Sciences,
Год журнала:
2025,
Номер
15(4), С. 363 - 363
Опубликована: Март 31, 2025
Bariatric
surgery
(BS)
is
an
effective
intervention
for
obesity,
inducing
significant
neurobiological
and
gut
microbiota
changes
that
influence
hunger,
appetite,
taste
perception,
long-term
metabolic
health.
This
narrative
review
examines
these
alterations
by
analyzing
recent
findings
from
clinical
preclinical
studies,
including
neuroimaging,
microbiome
sequencing,
hormonal
assessments.
BS
modulates
appetite-regulating
hormones,
reducing
ghrelin
while
increasing
glucagon-like
peptide-1
(GLP-1)
peptide
tyrosine-tyrosine
(PYY),
leading
to
enhanced
satiety
decreased
caloric
intake.
Neuroimaging
studies
reveal
structural
functional
in
brain
regions
involved
reward
processing
cognitive
control,
contributing
reduced
cravings
altered
food
choices.
Additionally,
reshapes
the
microbiota,
beneficial
species
such
as
Akkermansia
muciniphila,
which
pathways
through
short-chain
fatty
acid
production
bile
metabolism.
These
highlight
complex
interplay
between
post-surgical
regulation.
Understanding
mechanisms
essential
optimizing
post-operative
care,
nutritional
strategies
behavioral
interventions.
Future
research
should
explore
how
impact
outcomes,
guiding
development
of
targeted
therapies
enhance
recovery
quality
life
patients.
Язык: Английский
Dietary live microbe intake and its association with Parkinson’s disease in American adults: an NHANES analysis (1999–2018)
Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Май 29, 2025
Background
Diet
plays
a
crucial
role
in
sustaining
healthy
body,
and
microbes
have
attracted
significant
scholarly
interest
recent
years
as
an
essential
component
of
diet.
This
study
aims
to
explore
the
association
between
dietary
live
microbe
intake
incidence
Parkinson’s
Disease
(PD)
among
adults
over
40
old.
Methods
A
total
26,033
subjects
NHANES
1999–2018
were
included
this
study,
comprising
314
patients
with
PD,
which
divided
into
three
groups
based
on
their
foods
different
levels
microbial
content:
high,
medium,
low.
The
assessment
subjects’
was
conducted
through
self-reported
questionnaire.
Results
distribution
follows:
34.5%
had
low
intake,
45.4%
medium
20.1%
high
intake.
multivariable
logistic
regression
analysis
revealed
that
(OR
=
0.52,
95%
CI:
0.37–0.74)
0.73,
0.57–0.93)
exhibits
reduced
prevalence
PD
compared
those
Restricted
cubic
spline
(RCS)
indicated
linear
PD.
Furthermore,
stratified
analyses
demonstrate
research
variables
more
pronounced
without
obesity.
Conclusion
demonstrates
inverse
Язык: Английский