Neurobiological and Microbiota Alterations After Bariatric Surgery: Implications for Hunger, Appetite, Taste, and Long-Term Metabolic Health DOI Creative Commons
Sebastián Chapela, Ludwig Roberto Álvarez Córdova, Andrés Martinuzzi

и другие.

Brain Sciences, Год журнала: 2025, Номер 15(4), С. 363 - 363

Опубликована: Март 31, 2025

Bariatric surgery (BS) is an effective intervention for obesity, inducing significant neurobiological and gut microbiota changes that influence hunger, appetite, taste perception, long-term metabolic health. This narrative review examines these alterations by analyzing recent findings from clinical preclinical studies, including neuroimaging, microbiome sequencing, hormonal assessments. BS modulates appetite-regulating hormones, reducing ghrelin while increasing glucagon-like peptide-1 (GLP-1) peptide tyrosine-tyrosine (PYY), leading to enhanced satiety decreased caloric intake. Neuroimaging studies reveal structural functional in brain regions involved reward processing cognitive control, contributing reduced cravings altered food choices. Additionally, reshapes the microbiota, beneficial species such as Akkermansia muciniphila, which pathways through short-chain fatty acid production bile metabolism. These highlight complex interplay between post-surgical regulation. Understanding mechanisms essential optimizing post-operative care, nutritional strategies behavioral interventions. Future research should explore how impact outcomes, guiding development of targeted therapies enhance recovery quality life patients.

Язык: Английский

Neurobiological and Microbiota Alterations After Bariatric Surgery: Implications for Hunger, Appetite, Taste, and Long-Term Metabolic Health DOI Creative Commons
Sebastián Chapela, Ludwig Roberto Álvarez Córdova, Andrés Martinuzzi

и другие.

Brain Sciences, Год журнала: 2025, Номер 15(4), С. 363 - 363

Опубликована: Март 31, 2025

Bariatric surgery (BS) is an effective intervention for obesity, inducing significant neurobiological and gut microbiota changes that influence hunger, appetite, taste perception, long-term metabolic health. This narrative review examines these alterations by analyzing recent findings from clinical preclinical studies, including neuroimaging, microbiome sequencing, hormonal assessments. BS modulates appetite-regulating hormones, reducing ghrelin while increasing glucagon-like peptide-1 (GLP-1) peptide tyrosine-tyrosine (PYY), leading to enhanced satiety decreased caloric intake. Neuroimaging studies reveal structural functional in brain regions involved reward processing cognitive control, contributing reduced cravings altered food choices. Additionally, reshapes the microbiota, beneficial species such as Akkermansia muciniphila, which pathways through short-chain fatty acid production bile metabolism. These highlight complex interplay between post-surgical regulation. Understanding mechanisms essential optimizing post-operative care, nutritional strategies behavioral interventions. Future research should explore how impact outcomes, guiding development of targeted therapies enhance recovery quality life patients.

Язык: Английский

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