Cancers,
Год журнала:
2022,
Номер
14(15), С. 3786 - 3786
Опубликована: Авг. 3, 2022
Phosphatase
and
Tensin
Homolog
deleted
on
Chromosome
10
(PTEN)
is
one
of
the
critical
tumor
suppressor
genes
main
negative
regulator
PI3K
pathway.
PTEN
frequently
found
to
be
inactivated,
either
partially
or
fully,
in
various
malignancies.
The
PI3K/AKT
pathway
considered
signaling
cues
that
drives
proliferation
cells.
Perhaps
it
not
surprising,
then,
this
hyperactivated
highly
proliferative
tumors.
Importantly,
also
coordinates
epithelial–mesenchymal
transition
(EMT),
which
pivotal
for
initiation
metastases
hence
regarded
as
an
attractive
target
treatment
metastatic
cancer.
It
was
shown
suppresses
EMT,
although
exact
mechanism
effect
still
fully
understood.
This
review
attempt
systematize
published
information
role
development
malignant
tumors,
with
a
focus
regulation
EMT.
International Journal of Molecular Sciences,
Год журнала:
2020,
Номер
22(1), С. 173 - 173
Опубликована: Дек. 26, 2020
Breast
cancer
is
a
serious
health
problem
worldwide,
representing
the
second
cause
of
death
through
malignancies
among
women
in
developed
countries.
Population,
endogenous
and
exogenous
hormones,
physiological,
genetic
breast-related
factors
are
involved
breast
pathogenesis.
The
phosphatidylinositol
3-kinase
(PI3K)/protein
kinase
B
(AKT)/mammalian
target
rapamycin
(mTOR)
signaling
pathway
cell
proliferation,
survival,
invasion,
migration,
apoptosis,
glucose
metabolism
DNA
repair.
In
tumors,
PIK3CA
somatic
mutations
have
been
reported,
located
exon
9
20.
Up
to
40%
estrogen
receptor
(ER)
positive
human
epidermal
growth
factor
2
(HER2)
-negative
primary
metastatic
cancer.
HER2
overexpressed
20–30%
cancers.
HER1,
HER2,
HER3
HER4
membrane
tyrosine
kinases
HER
which
various
ligands
can
be
attached,
leading
PI3K/AKT
activation.
Currently,
clinical
studies
evaluate
inhibitors
PI3K/AKT/mTOR
axis.
main
purpose
this
review
present
general
aspects
cancer,
components
AKT
pathway,
that
activate
protein
B,
PI3K/AKT-breast
mutations,
PI3K/AKT/mTOR-inhibitors,
relationship
between
everolimus,
temsirolimus
endocrine
therapy.
Abstract
The
PI3
K/AKT/mTOR
signalling
pathway
plays
an
important
role
in
the
regulation
of
signal
transduction
and
biological
processes
such
as
cell
proliferation,
apoptosis,
metabolism
angiogenesis.
Compared
with
those
other
pathways,
components
PI3K/AKT/mTOR
are
complicated.
regulatory
mechanisms
functions
many
human
diseases,
including
ischaemic
brain
injury,
neurodegenerative
tumours.
inhibitors
include
single-component
dual
inhibitors.
Numerous
PI3K
have
exhibited
good
results
preclinical
studies,
some
been
clinically
tested
haematologic
malignancies
solid
In
this
review,
we
briefly
summarize
research
on
discuss
structural
composition,
activation,
communication
processes,
pathogenesis
diseases
Cancers,
Год журнала:
2021,
Номер
13(16), С. 3949 - 3949
Опубликована: Авг. 5, 2021
The
PI3K/AKT
pathway
is
one
of
the
most
frequently
over-activated
intracellular
pathways
in
several
human
cancers.
This
pathway,
acting
on
different
downstream
target
proteins,
contributes
to
carcinogenesis,
proliferation,
invasion,
and
metastasis
tumour
cells.
A
multi-level
impairment,
involving
mutation
genetic
alteration,
aberrant
regulation
miRNAs
sequences,
abnormal
phosphorylation
cascade
factors,
has
been
found
multiple
cancer
types.
deregulation
this
counteracts
common
therapeutic
strategies
multidrug
resistance.
In
review,
we
underline
involvement
patho-physiological
cell
survival
mechanisms,
emphasizing
its
key
role
development
drug
We
also
provide
an
overview
potential
inhibition
currently
available.
Journal of Hematology & Oncology,
Год журнала:
2021,
Номер
14(1)
Опубликована: Авг. 21, 2021
Biomarkers-guided
precision
therapeutics
has
revolutionized
the
clinical
development
and
administration
of
molecular-targeted
anticancer
agents.
Tailored
cancer
therapy
exhibits
better
response
rate
compared
to
unselective
treatment.
Protein
kinases
have
critical
roles
in
cell
signaling,
metabolism,
proliferation,
survival
migration.
Aberrant
activation
protein
is
for
tumor
growth
progression.
Hence,
are
key
targets
molecular
targeted
therapy.
The
serine/threonine
kinase
Akt
frequently
activated
various
types
cancer.
Activation
promotes
progression
drug
resistance.
Since
first
inhibitor
was
reported
2000,
many
inhibitors
been
developed
evaluated
either
early
or
late
stage
trials,
which
take
advantage
liquid
biopsy
genomic
profiling
realize
personalized
Two
inhibitors,
capivasertib
ipatasertib,
being
tested
phase
III
trials
Here,
we
highlight
recent
progress
signaling
pathway,
review
up-to-date
data
from
studies
discuss
potential
biomarkers
that
may
help
treatment
with
inhibitors.
In
addition,
also
how
confer
vulnerability
cells
some
kinds
Advanced Materials,
Год журнала:
2023,
Номер
36(4)
Опубликована: Авг. 7, 2023
Abstract
Lipid
nanoparticles
(LNPs)
are
currently
the
most
promising
clinical
nucleic
acids
drug
delivery
vehicles.
LNPs
prevent
degradation
of
cargo
during
blood
circulation.
Upon
entry
into
cell,
specific
components
lipid
can
promote
endosomal
escape
acids.
These
basic
properties
as
acid
carriers.
As
exhibit
hepatic
aggregation
characteristics,
enhancing
targeting
out
liver
is
a
crucial
way
to
improve
administrated
in
vivo.
Meanwhile,
loaded
often
considered
inadequate,
and
therefore,
much
effort
devoted
intracellular
release
efficiency
Here,
different
strategies
efficiently
deliver
from
concluded
their
mechanisms
investigated.
In
addition,
based
on
information
that
trials
or
have
completed
trials,
issues
necessary
be
approached
translation
discussed,
which
it
hoped
will
shed
light
development
LNP
drugs.
Aging,
Год журнала:
2020,
Номер
12(9), С. 8137 - 8150
Опубликована: Май 4, 2020
Methyltransferase-like
protein
3
(METTL3)
regulates
multiple
cell
functions
and
diseases
by
modulatingN
6methyladenosine
(m
6
A)
modifications.However,
it
is
still
unclear
whether
METTL3
involves
in
the
pathogenesis
of
diabetic
retinopathy
(DR).In
present
study,
we
found
that
high-glucose
inhibited
RPE
proliferation,
promoted
apoptosis
pyroptosis
a
time-dependent
manner.In
addition,
both
mRNA
miR-25-3p
were
low-expressed
peripheral
venous
blood
samples
diabetes
mellitus
(DM)
patients
compared
to
normal
volunteers,
expressions
cells.As
expected,
upregulation
alleviated
cytotoxic
effects
on
cells,
knockdown
had
opposite
effects.Additionally,
overexpression
increased
levels
cells
microprocessor
DGCR8-dependent
manner,
ablation
abrogated
overexpressed
treated
cells.Furthermore,
PTEN
could
be
negatively
regulated
miR-25-3p,
phosphorylated
Akt
(p-Akt)
targeting
miR-25-3p/PTEN
axis.Consistently,
protective
with
high-glucose.Collectively,
rescued
viability
highglucose
miR-25-3p/PTEN/Akt
signaling
cascade.
