Modulating Microbiota as a New Strategy for Breast Cancer Prevention and Treatment DOI Creative Commons
Huixin Wu, Sebanti Ganguly, Trygve O. Tollefsbol

и другие.

Microorganisms, Год журнала: 2022, Номер 10(9), С. 1727 - 1727

Опубликована: Авг. 27, 2022

Breast cancer (BC) is the most common in women United States. There has been an increasing incidence and decreasing mortality rate of BC cases over past several decades. Many risk factors are associated with BC, such as diet, aging, personal family history, obesity, some environmental factors. Recent studies have shown that healthy individuals patients different microbiota composition, indicating microbiome a new factor for BC. Gut breast alterations prognosis. This review will evaluate altered populations gut, tissue, milk patients, well mechanisms interactions between modulation Probiotics prebiotics commercially available dietary supplements to alleviate side-effects therapies. They also shape population human gut microbiome. evaluates novel means modulating by nutritional treatment probiotics emerging promising strategies prevention The mechanistic role probiotic partially depend on estrogen metabolism, systematic immune regulation, epigenetics regulation.

Язык: Английский

Decoding the Tumor-Associated Microbiota: From Origins to Nanomedicine Applications in Cancer Therapy DOI Creative Commons

Ruiqi Wang,

Weizheng Li, Hongqian Cao

и другие.

Biology, Год журнала: 2025, Номер 14(3), С. 243 - 243

Опубликована: Фев. 27, 2025

Growing evidence reveals that the tumor microbiome—comprising distinct microbial communities within neoplastic tissues—exerts a profound influence on cancer initiation, progression, and therapeutic response. These microbes actively reshape microenvironment (TME) through metabolite secretion, modulation of immune pathways, direct interactions with host cells, thereby affecting biology outcomes. Despite substantial heterogeneity among types, recent insights underscore microbiome’s potential as both diagnostic/prognostic biomarker targetable component for innovative treatments. In this review, we synthesize emerging knowledge mechanistic roles tumor-associated microbiota in shaping TME, focus how these discoveries can guide novel strategies. We further explore interdisciplinary advances, including convergence microbiomics nanotechnology, to enhance drug delivery, circumvent resistance, foster TME remodeling. By highlighting cutting-edge developments, our review underscores transformative integrating microbiome research into precision oncology advancing more personalized therapies.

Язык: Английский

Процитировано

1
Gut Microbiota as Potential Biomarker and/or Therapeutic Target to Improve the Management of Cancer: Focus on Colibactin-Producing Escherichia coli in Colorectal Cancer DOI Open Access
Julie Véziant, Romain Villéger, Nicolas Barnich

и другие.

Cancers, Год журнала: 2021, Номер 13(9), С. 2215 - 2215

Опубликована: Май 5, 2021

The gut microbiota is crucial for physiological development and immunological homeostasis. Alterations of this microbial community called dysbiosis, have been associated with cancers such colorectal (CRC). pro-carcinogenic potential dysbiotic has demonstrated in the colon. Recently role efficacy anti-tumor therapeutic strategies described digestive other (e.g., melanoma sarcoma). Different bacterial species seem to be implicated these mechanisms: F. nucleatum, B. fragilis, colibactin-associated E. coli (CoPEC). CoPEC bacteria are prevalent colonic mucosa patients CRC they promote carcinogenesis susceptible mouse models CRC. In review, we report preclinical clinical data that suggest could a new factor predictive poor outcomes used improve cancer management. Moreover, describe possibility using as targets.

Язык: Английский

Процитировано

49
Comprehensive profiles and diagnostic value of menopausal-specific gut microbiota in premenopausal breast cancer DOI Creative Commons
Ming‐Feng Hou,

Fu Ou‐Yang,

Chung-Liang Li

и другие.

Experimental & Molecular Medicine, Год журнала: 2021, Номер 53(10), С. 1636 - 1646

Опубликована: Окт. 1, 2021

Abstract In Western countries, breast cancer tends to occur in older postmenopausal women. However, Asian the proportion of younger premenopausal patients is increasing. Increasing evidence suggests that gut microbiota plays a critical role cancer. studies on context have mainly focused Little known about This study aimed comprehensively explore microbial profiles, diagnostic value, and functional pathways patients. Here, we analyzed 267 with different menopausal statuses age-matched female controls. The α-diversity was significantly reduced patients, β-diversity differed between By performing multiple analyses classification, 14 markers were identified Bacteroides fragilis specifically found young women Klebsiella pneumoniae statuses. addition, menopausal-specific could exhibit excellent discriminatory ability distinguishing from Finally, Our findings provide first differs shed light for diagnosis investigation, ultimately providing noninvasive approach detection novel strategy preventing

Язык: Английский

Процитировано

46
The Role of Microbiota in the Immunopathogenesis of Endometrial Cancer DOI Open Access
Małgorzata Sobstyl,

Peet Brecht,

Anna Sobstyl

и другие.

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(10), С. 5756 - 5756

Опубликована: Май 20, 2022

The female reproductive tract hosts a specific microbiome, which plays crucial role in sustaining equilibrium and good health. In the majority of women, microbiota (all bacteria, viruses, fungi, other single-celled organisms within human body) vaginal cervical microenvironment are dominated by Lactobacillus species, benefit host through symbiotic relationships, comparison to uterus, fallopian tubes, ovaries, may contain low-biomass microbiome with diverse mixture microorganisms. Although disruption balance develops, altered immune metabolic signaling cause an impact on diseases such as cancer. These pathophysiological modifications gut–uterus axis spark gynecological cancers. New information displays that gastrointestinal dysbiosis (disruption homeostasis) can play active advancement metastasis neoplasms, cervical, endometrial, ovarian Understanding relationship between endometrial cancer is critical for prognosis, diagnosis, prevention, development innovative treatments. Identifying become effective method characterization involved carcinogenesis. aim this study was summarize current state knowledge describes correlation regard formation immunological pathologies.

Язык: Английский

Процитировано

36
Modulating Microbiota as a New Strategy for Breast Cancer Prevention and Treatment DOI Creative Commons
Huixin Wu, Sebanti Ganguly, Trygve O. Tollefsbol

и другие.

Microorganisms, Год журнала: 2022, Номер 10(9), С. 1727 - 1727

Опубликована: Авг. 27, 2022

Breast cancer (BC) is the most common in women United States. There has been an increasing incidence and decreasing mortality rate of BC cases over past several decades. Many risk factors are associated with BC, such as diet, aging, personal family history, obesity, some environmental factors. Recent studies have shown that healthy individuals patients different microbiota composition, indicating microbiome a new factor for BC. Gut breast alterations prognosis. This review will evaluate altered populations gut, tissue, milk patients, well mechanisms interactions between modulation Probiotics prebiotics commercially available dietary supplements to alleviate side-effects therapies. They also shape population human gut microbiome. evaluates novel means modulating by nutritional treatment probiotics emerging promising strategies prevention The mechanistic role probiotic partially depend on estrogen metabolism, systematic immune regulation, epigenetics regulation.

Язык: Английский

Процитировано

36