Recent advances and clinical translation of liposomal delivery systems in cancer therapy

European Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 193, С. 106688 - 106688

Опубликована: Янв. 1, 2024

The limitations of conventional cancer treatment are driving the emergence and development nanomedicines. Research in liposomal nanomedicine for therapy is rapidly increasing, opening up new horizons treatment. Liposomal nanomedicine, which focuses on targeted drug delivery to improve therapeutic effect while reducing damage normal tissues cells, has great potential field therapy. This review aims clarify advantages systems We describe recent understanding spatiotemporal fate liposomes organism after different routes administration. Meanwhile, various types liposome-based that exert their respective side effects were discussed. Moreover, combination agents with other therapies (such as photodynamic photothermal therapy) demonstrated enhanced tumor-targeting efficiency efficacy. Finally, opportunities challenges faced by liposome nanoformulations entering clinical highlighted.

Язык: Английский

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Design of Magnetic Hydrogels for Hyperthermia and Drug Delivery

Polymers, Год журнала: 2021, Номер 13(23), С. 4259 - 4259

Опубликована: Дек. 4, 2021

Hydrogels are spatially organized hydrophilic polymeric systems that exhibit unique features in hydrated conditions. Among the hydrogel family, composite hydrogels a special class defined as filler-containing with some tailor-made properties. The family includes magnetic-nanoparticle-integrated hydrogels. Magnetic (MHGs) show magneto-responsiveness, which is observed when they placed magnetic field (static or oscillating). Because of their tunable porosity and internal morphology can be used several biomedical applications, especially diffusion-related smart devices. External stimuli may influence physical chemical changes these hydrogels, particularly terms volume shape morphing. One most significant external for field. This review embraces brief overview fabrication MHGs two usages area: drug delivery hyperthermia-based anti-cancer activity. As saturation magnetization imposed on MHGs, easily heated presence an alternating temperature increment dependent nanoparticle concentration exposure time. Herein, we also discuss mode different therapies based non-contact hyperthermia heating.

Язык: Английский

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Advances in screening hyperthermic nanomedicines in 3D tumor models

Nanoscale Horizons, Год журнала: 2024, Номер 9(3), С. 334 - 364

Опубликована: Янв. 1, 2024

Integrating the advances of emerging hyperthermia techniques with 3D tumor models and non-invasive temperature control systems can contribute to identifying top-performing hyperthermic nanomedicines in preclinical evaluation stages.

Язык: Английский

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Targeted intra-tumoral hyperthermia using uniquely biocompatible gold nanorods induces strong immunogenic cell death in two immunogenically ‘cold’ tumor models

Frontiers in Immunology, Год журнала: 2025, Номер 15

Опубликована: Янв. 13, 2025

Introduction Hyperthermia is an established adjunct in multimodal cancer treatments, with mechanisms including cell death, immune modulation, and vascular changes. Traditional hyperthermia applications are resource-intensive often associated patient morbidity, limiting their clinical accessibility. Gold nanorods (GNRs) offer a precise, minimally invasive alternative by leveraging near-infrared (NIR) light to deliver targeted therapy (THT). THT induces controlled tumor heating, promoting immunogenic death (ICD) modulating the microenvironment (TME) enhance engagement. This study explores synergistic potential of GNR-mediated immunotherapies immunogenically ‘cold’ tumors achieve durable anti-tumor immunity. Methods GNRs from Sona Nanotech Inc.™ were intratumorally injected activated using NIR induce mild (42–48°C) for 5 minutes. Tumor responses analyzed pathways modulation. The effects assessed alone combination intratumoral interleukin-2 (i.t. IL-2) or systemic PD-1 checkpoint blockade. Immune infiltration, gene expression changes, growth kinetics evaluated. Results reduced burden through mechanisms, upregulated ICD marked calreticulin exposure within 48 hours. By hours, CD45+ levels increased, increased immunosuppressive M2 macrophages. While led innate stimulations highlighted upregulation STING cGAS pathway enhanced M1 dendritic levels, regrowth was observed six days post-treatment. To THT's effects, combined Sequential administration i.t. IL-2 post-THT induced robust CD8+ T-cell infiltration sustained regression both treated distant tumors, accompanied emergence memory T cells. However, IL-2-induced T-reg populations also endpoint suggesting that could be further enhanced. Additionally, expression, which cells THT, inhibition, augmenting engagement TME. Discussion These combinatory treatments demonstrated memory. Collectively, effectively reduces remodels TME, potentiating immunity enhancing impact complementary immunotherapies.

Язык: Английский

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Understanding MNPs Behaviour in Response to AMF in Biological Milieus and the Effects at the Cellular Level: Implications for a Rational Design That Drives Magnetic Hyperthermia Therapy toward Clinical Implementation

Cancers, Год журнала: 2021, Номер 13(18), С. 4583 - 4583

Опубликована: Сен. 12, 2021

Hyperthermia has emerged as a promising alternative to conventional cancer therapies and in fact, traditional hyperthermia is now commonly used combination with chemotherapy or surgery during treatment. Nevertheless, non-specific application of generates various undesirable side-effects, such that nano-magnetic arisen possible solution this problem. This technique induce based on the intrinsic capacity magnetic nanoparticles accumulate given target area respond alternating fields (AMFs) by releasing heat, different principles physics. Unfortunately, clinical implementation not been fluid few trials have carried out. In review, we want demonstrate need for more systematic basic research area, many sub-cellular molecular mechanisms associated approach remain unclear. As such, shall consider here biological effects occur why theoretically well-designed nano-system fails physiological conditions. Moreover, will offer some guidelines may help establish successful strategies through rational design hyperthermia.

Язык: Английский

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New Insights into YAP/TAZ-TEAD-Mediated Gene Regulation and Biological Processes in Cancer

Cancers, Год журнала: 2023, Номер 15(23), С. 5497 - 5497

Опубликована: Ноя. 21, 2023

The Hippo pathway is conserved across species. Key mammalian kinases, including MST1/2 and LATS1/2, inhibit cellular growth by inactivating the TEAD coactivators, YAP, TAZ. Extensive research has illuminated roles of signaling in cancer, development, regeneration. Notably, dysregulation components not only contributes to tumor metastasis, but also renders tumors resistant therapies. This review delves into recent on YAP/TAZ-TEAD-mediated gene regulation biological processes cancer. We focus several key areas: newly identified molecular patterns YAP/TAZ activation, emerging mechanisms that contribute metastasis cancer therapy resistance, unexpected suppression, advances therapeutic strategies targeting this pathway. Moreover, we provide an updated view YAP/TAZ's functions, discuss ongoing controversies, offer perspectives specific debated topics rapidly evolving field.

Язык: Английский

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Harnessing Hyperthermia: Molecular, Cellular, and Immunological Insights for Enhanced Anticancer Therapies

Integrative Cancer Therapies, Год журнала: 2024, Номер 23

Опубликована: Янв. 1, 2024

Hyperthermia, the raising of tumor temperature (≥39°C), holds great promise as an adjuvant treatment for cancer therapy. This review focuses on 2 key aspects hyperthermia: its molecular and cellular effects impact immune system. Hyperthermia has profound critical biological processes. Increased temperatures inhibit DNA repair enzymes, making cells more sensitive to chemotherapy radiation. Elevated also induce cell cycle arrest trigger apoptotic pathways. Furthermore, hyperthermia modifies expression heat shock proteins, which play vital roles in therapy, including enhancing responses. Hyperthermic treatments have a significant body’s response against tumors, potentially improving efficacy checkpoint inhibitors. Mild systemic (39°C-41°C) mimics fever, activating metabolic rates. Intense above 50°C can release antigens, reactions. Using photothermal nanoparticles targeted heating drug delivery modulate response. emerges cost-effective well-tolerated therapy when integrated with immunotherapy. comprehensive serves valuable resource selection patient-specific guidance future experimental studies.

Язык: Английский

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Hyperthermia combined with immune checkpoint inhibitor therapy: Synergistic sensitization and clinical outcomes

Cancer Medicine, Год журнала: 2022, Номер 12(3), С. 3201 - 3221

Опубликована: Июль 31, 2022

Abstract Background Within the field of oncotherapy, research interest regarding immunotherapy has risen to point that it is now seen as a key application. However, inherent disadvantages immune checkpoint inhibitors (ICIs), such their low response rates and immune‐related adverse events (irAEs), currently restrict clinical Were these be overcome, more patients could derive prolonged benefits from ICIs. At present, many basic experiments studies using hyperthermia combined with ICI treatment (HIT) have been performed shown potential address above challenges. Therefore, this review extensively summarizes knowledge progress HIT for analysis discusses effect feasibility. Methods In review, we explored PubMed clinicaltrials.gov databases, regard searching terms “immune inhibitor, immunotherapy, hyperthermia, ablation, photothermal therapy”. Results By reviewing literature, analyzed how influences tumor immunology improves efficacy ICI. Hyperthermia can trigger series multifactorial molecular cascade reactions between tumors immunization significantly induce cytological modifications within microenvironment (TME). The pharmacological potency ICIs enhanced greatly through immunomodulatory amelioration immunosuppression, activation immunostimulation. Emerging trials outcome verified enriched theoretical foundation synergistic sensitization. Conclusion starting transition preclinical investigations. Several sensitization mechanisms reflected demonstrated significant survival pioneering trials. Further into basis practical standards HIT, larger‐scale involving cancer types, will necessary future

Язык: Английский

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Pt-Au Nanoparticles in Combination with Near-Infrared-Based Hyperthermia Increase the Temperature and Impact on the Viability and Immune Phenotype of Human Hepatocellular Carcinoma Cells

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1574 - 1574

Опубликована: Фев. 13, 2025

Near-infrared light (NIR)-responsive metal-based nanoparticles (NPs) could be used for tumour therapy. We examined how platinum (Pt), gold (Au), and core-shell Pt-Au NPs affect the viability of human hepatocellular carcinoma (HCC) cell lines (Hep3B, HepG2, Huh7D-12) alone in combination with NIR exposure. In addition, expression immune checkpoint molecules (ICMs) on cells was analysed. revealed that cytotoxicity programmed death induction Au toward HCC enhanced by 960 nm a different way. were only particles resulted an additional temperature increase up to 2 °C after NIR. Regarding phenotype, not all experienced changes phenotype. itself trigger alterations, while did significantly most ICMs, such as PD-L1, HVEM, CD70, ICOS-L, Ox40-L, TNFRSF9. The prominent ICMs HepG2 cells. conclude thermotherapeutic effect NP application beneficial multimodal therapy settings liver cancer selected patients.

Язык: Английский

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Advances and applications of hyperthermia in tumor therapy: Mechanisms, techniques, and clinical integration

International Communications in Heat and Mass Transfer, Год журнала: 2025, Номер 164, С. 108895 - 108895

Опубликована: Март 29, 2025

Язык: Английский

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