Mini-Reviews in Medicinal Chemistry,
Год журнала:
2024,
Номер
24(21), С. 1953 - 1969
Опубликована: Апрель 19, 2024
:
Glioblastoma
multiforme
(GBM),
a
solid
tumor
that
develops
from
astrocytes,
is
one
of
the
most
aggressive
types
brain
cancer.
While
there
have
been
improvements
in
efficacy
treating
GBM,
many
problems
remain,
especially
with
traditional
therapy
methods.
Therefore,
recent
studies
extensively
focused
on
developing
novel
therapeutic
agents
for
combating
glioblastoma.
Natural
polyphenols
studied
their
potential
as
chemopreventive
and
chemotherapeutic
due
to
wide
range
positive
qualities,
including
antioxidant,
antiinflammatory,
cytotoxic,
antineoplastic,
immunomodulatory
activities.
These
natural
compounds
suggested
act
via
modulated
various
macromolecules
within
cells,
microRNAs
(miRNAs),
which
play
crucial
role
molecular
milieu.
In
this
article,
we
focus
how
may
inhibit
growth
by
influencing
expression
key
miRNAs
regulate
oncogenes
suppressor
genes
International Journal of Biological Sciences,
Год журнала:
2023,
Номер
19(6), С. 1813 - 1830
Опубликована: Янв. 1, 2023
Damage
to
vascular
endothelial
cells
(VECs)
and
smooth
muscle
(VSMCs)
caused
by
oxidized
low-density
lipoprotein
(oxLDL)
contributes
cardiovascular
cerebrovascular
diseases.
Protection
effects
of
Berberine
(BBR)
on
the
system
have
been
reported,
however,
molecular
mechanism
protection
is
still
unclear.
In
this
study,
we
established
two
hyperlipidemia
models
in
zebrafish
VEC-VSMC
co-culture
using
high-cholesterol
food
(HCF)
oxLDL,
respectively.
We
demonstrated
that
HCF
doubled
total
cholesterol
glyceride
levels,
BBR
decreased
these
indices
a
concentration-dependent
manner.
Lipid
staining
hematoxylin-eosin
revealed
inhibited
oxLDL-induced
VSMC
bulge-like
proliferation
migration
toward
VECs
prevented
HCF-induced
trunk
obstruction
zebrafish.
Immunoblot
analysis,
cell
immunofluorescence,
co-immunoprecipitation
assays,
transmission
electron
microscopy
showed
oxLDL/HCF
increased
lectin-like
oxLDL
receptor-1
(LOX-1)
expression
at
least
5-fold
significantly
autophagolysosome
formation
blood
vessel
These
observations
were
associated
with
endothelial-to-mesenchymal
transition
(EMT)
triggered
VE-cadherin
ectopic
VSMCs,
they
responsible
for
aberrant
occlusion.
However,
BBR,
promoting
autolysosome
degradation
LOX-1,
reversed
above
events
maintained
intracellular
homeostasis
integrity.
conclusion,
regulation
autophagy
may
be
an
effective
approach
treating
diseases
reducing
LOX-1
protein
level.
can
protect
vessels
adjusting
oxLDL-LOX-1-EMT-autophagy
axis.
This
study
step
development
new
applications
BBR.
Microorganisms,
Год журнала:
2024,
Номер
12(3), С. 450 - 450
Опубликована: Фев. 23, 2024
Addressing
pressing
health
concerns,
modern
medical
research
seeks
to
identify
new
antimicrobials
combat
drug
resistance,
novel
molecules
for
cancer
treatment,
and
antioxidants
inflammation-related
diseases.
Pisolithus
(Basidiomycota)
is
a
ubiquitous
widely
distributed
fungal
genus
in
forest
ecosystems,
known
establishing
ectomycorrhizal
associations
with
range
of
host
plants,
enhancing
their
growth,
conferring
protection
against
biotic
abiotic
stresses.
Beyond
ecological
applications,
yields
bioactive
compounds
medicinal
potential.
This
comprehensive
review
explores
the
transversal
biological
activity
fungi,
aiming
provide
thorough
overview
antimicrobial,
anticancer,
antioxidant
The
focus
on
elucidating
within
trigger
further
innovative
applications.
Compounds
from
displayed
antimicrobial
broad
spectrum
microorganisms,
including
antibiotic-resistant
bacteria.
efficacy
Pisolithus-derived
matched
established
medications,
emphasizing
therapeutic
In
anticancer
research,
triterpene
pisosterol
stood
out
documented
cytotoxicity
various
cell
lines,
showcasing
promise
therapies.
was
also
recognized
as
potential
source
antioxidants,
basidiocarps
exhibiting
high
activity.
vivo
validation
studies
broader
compounds,
together
mechanistic
insights
into
mode
action
are
compelling
areas
future
research.
Mini-Reviews in Medicinal Chemistry,
Год журнала:
2024,
Номер
24(21), С. 1953 - 1969
Опубликована: Апрель 19, 2024
:
Glioblastoma
multiforme
(GBM),
a
solid
tumor
that
develops
from
astrocytes,
is
one
of
the
most
aggressive
types
brain
cancer.
While
there
have
been
improvements
in
efficacy
treating
GBM,
many
problems
remain,
especially
with
traditional
therapy
methods.
Therefore,
recent
studies
extensively
focused
on
developing
novel
therapeutic
agents
for
combating
glioblastoma.
Natural
polyphenols
studied
their
potential
as
chemopreventive
and
chemotherapeutic
due
to
wide
range
positive
qualities,
including
antioxidant,
antiinflammatory,
cytotoxic,
antineoplastic,
immunomodulatory
activities.
These
natural
compounds
suggested
act
via
modulated
various
macromolecules
within
cells,
microRNAs
(miRNAs),
which
play
crucial
role
molecular
milieu.
In
this
article,
we
focus
how
may
inhibit
growth
by
influencing
expression
key
miRNAs
regulate
oncogenes
suppressor
genes
