Seminars in Musculoskeletal Radiology,
Год журнала:
2024,
Номер
28(01), С. 049 - 061
Опубликована: Фев. 1, 2024
Abstract
Sarcomas
are
heterogeneous
rare
tumors
predominantly
affecting
the
musculoskeletal
(MSK)
system.
Due
to
significant
variations
in
their
natural
history
and
variable
response
conventional
treatments,
discovery
of
novel
diagnostic
prognostic
biomarkers
guide
therapeutic
decision-making
is
an
active
ongoing
field
research.
As
new
cellular,
molecular,
metabolic
continue
be
discovered,
quantitative
radiologic
imaging
becoming
increasingly
important
sarcoma
management.
Radiomics
offers
potential
for
discovering
predictive
using
standard-of-care
medical
imaging.
In
this
review,
we
detail
core
concepts
radiomics
application
date
MSK
Also
described
specific
challenges
related
radiomic
studies,
as
well
viewpoints
on
clinical
adoption
future
perspectives
field.
Biomarker Research,
Год журнала:
2023,
Номер
11(1)
Опубликована: Март 9, 2023
Abstract
Immune
checkpoint
inhibitors
(ICIs)
targeting
PD-1
or
PD-L1
have
emerged
as
a
revolutionary
treatment
strategy
for
human
cancer
patients.
However,
the
response
rate
to
ICI
therapy
varies
widely
among
different
types
of
tumours,
we
are
beginning
gain
insight
into
mechanisms
well
biomarkers
therapeutic
and
resistance.
Numerous
studies
highlighted
dominant
role
cytotoxic
T
cells
in
determining
ICIs.
Empowered
by
recent
technical
advances,
such
single-cell
sequencing,
tumour-infiltrating
B
been
identified
key
regulator
several
solid
tumours
affecting
tumour
progression
In
current
review,
summarized
advances
regarding
underlying
therapy.
Some
shown
that
B-cell
abundance
is
positively
associated
with
favourable
clinical
outcomes,
while
others
indicated
they
tumour-promoting,
implying
biological
function
complex
landscape.
The
molecular
involved
multiple
aspects
functions
cells,
including
activation
CD8+
secretion
antibodies
cytokines,
facilitation
antigen
presentation
process.
addition,
other
crucial
mechanisms,
regulatory
(Bregs)
plasma
discussed.
Here,
summarizing
dilemmas
studies,
depicted
landscape
cancers
paved
way
future
research
this
field.
Graphical
Cardiometry,
Год журнала:
2022,
Номер
24, С. 58 - 60
Опубликована: Ноя. 30, 2022
Identification
of
the
molecular
genetic
phenotype
breast
carcinomas
is
an
important
prognostic
factor
disease,
and
helps
to
personalize
treatment
such
patients.
According
evidence
data
from
reference
literature,
cancer
(BC)
with
a
triple
negative
among
all
subtypes
accounts
for
about
10-24%,
showing
most
aggressive
progression
and,
as
result,
has
worst
prognosis.
Cardiometry,
Год журнала:
2022,
Номер
24, С. 56 - 58
Опубликована: Ноя. 30, 2022
Low
survival
and
poor
quality
of
life
in
patients
with
high-grade
brain
gliomas
(HGG)
dictate
the
need
to
develop
promote
new
approaches,
including
accompanying
transcranial
magnetic
therapy
(TMT)
pulse-type
field
(PT
MF)
ultra-low-frequency
fields
(ULF
MF),
characterized
by
their
non-invasiveness
safety
applied
procedures.
The
key
point
these
original
wave
technologies
is
construction
algorithms
actions
based
on
principles
activation
therapy,
which
was
developed
as
a
result
discovery
“Pattern
development
qualitatively
differing
general
nonspecific
adaptational
reactions
organism”
(Scientific
Discovery
Registration
Certificate
No.
158
issued
Committee
Inventions
Discoveries
at
Council
Ministers
USSR,
1975).
Cardiometry,
Год журнала:
2022,
Номер
24, С. 26 - 27
Опубликована: Ноя. 30, 2022
Genetically
modified
T
cells
expressing
chimeric
receptors
(CAR-T)
have
become
an
important
tool
for
the
treatment
of
CD19+
hematological
tumors.
Due
to
a
single-chain
variable
fragment
antibody
as
part
CAR
receptor,
acquire
their
specificity
against
selected
tumorassociated
antigens.
The
3rd
generation
also
includes
transmembrane,
co-stimulatory
domains,
and
tyrosine
activation
motifs
derived
from
CD3z.
Cardiometry,
Год журнала:
2022,
Номер
24, С. 36 - 37
Опубликована: Ноя. 30, 2022
Molecules
containing
the
N-acetylgalactosamine
residue
are
capable
to
bind
asialoglycoprotein
receptor,
a
protein
presented
on
surface
of
liver
tumor
cells;
therefore
it
is
suggested
that
doxorubicin
conjugates
such
fragment
can
be
delivered
hepatocellular
carcinoma
cells
as
target,
and
then,
upon
hydrazone
link
splitting,
in
acidic
environment
release
active
substance.
Cardiometry,
Год журнала:
2022,
Номер
24, С. 48 - 49
Опубликована: Ноя. 30, 2022
The
thyroid
and
the
gonadal
(HPG)
regulatory
axes
are
interconnected
act
together
as
a
single
system
their
imbalance
leads
to
pathological
responses
of
organism
[1,
2].
involvement
sex
hormones
in
development
malignant
process
has
been
discussed
for
many
decades.
Cancers,
Год журнала:
2022,
Номер
14(5), С. 1293 - 1293
Опубликована: Март 2, 2022
Soft-tissue
sarcomas
are
biologically
heterogenous
tumors
arising
from
connective
tissues
with
over
100
subtypes.
Although
account
for
<1%
of
all
adult
malignancies,
retroperitoneal
a
distinct
subgroup
accounting
<10%
sarcomatous
tumors.
There
have
been
considerable
advancements
in
the
understanding
and
treatment
sarcoma
last
decade,
standard
consisting
upfront
primary
surgical
resection.
The
evidence
surrounding
addition
radiation
therapy
remains
controversial.
no
regards
to
systemic
therapy,
including
immunotherapy.
Adjunctive
largely
dictated
by
expert
consensus
preferences
at
individual
centers
or
participation
clinical
trials.
In
this
2021
review,
we
detail
anatomical
boundaries
retroperitoneum,
characteristics,
contemporary
care
well
as
recent
care.
Ongoing
international
collaborations
encouraged
advance
our
complex
disease.
Theranostics,
Год журнала:
2022,
Номер
12(14), С. 6106 - 6129
Опубликована: Янв. 1, 2022
Sarcomas
are
uncommon
malignancies
of
mesenchymal
origin
that
can
arise
throughout
the
human
lifespan,
at
any
part
body.Surgery
remains
optimal
treatment
modality
whilst
response
to
conventional
treatments,
such
as
chemotherapy
and
radiation,
is
minimal.Immunotherapy
has
emerged
a
novel
approach
treat
different
cancer
types
but
efficacy
in
soft
tissue
sarcoma
bone
limited
distinct
subtypes.Growing
evidence
shows
cancer-stroma
cell
interactions
their
microenvironment
play
key
role
effectiveness
immunotherapy.However,
pathophysiological
immunological
properties
tumor
relation
immunotherapy
advances,
not
been
broadly
reviewed.Here,
we
provide
an
up-to-date
overview
modalities
potential
treatments
for
sarcoma,
identify
barriers
posed
by
immunotherapy,
highlight
relevance
impeding
effectiveness,
suggest
mechanisms
overcome
these
barriers.
Biomarker Research,
Год журнала:
2023,
Номер
11(1)
Опубликована: Авг. 23, 2023
Abstract
Sarcomas
are
a
group
of
diverse
and
complex
cancers
mesenchymal
origin
that
remains
poorly
understood.
Recent
developments
in
cancer
immunotherapy
have
demonstrated
potential
for
better
outcomes
with
immune
checkpoint
inhibition
some
sarcomas
compared
to
conventional
chemotherapy.
Immune
inhibitors
(ICIs)
key
agents
immunotherapy,
demonstrating
improved
many
tumor
types.
However,
most
patients
sarcoma
do
not
benefit
from
treatment,
highlighting
the
need
identification
development
predictive
biomarkers
response
ICIs.
In
this
review,
we
first
discuss
United
States
(US)
Food
Drug
Administration
(FDA)-approved
European
Medicines
Agency
(EMA)-approved
biomarkers,
as
well
limitations
their
use
sarcomas.
We
then
review
eight
rationalize
utility
These
include
gene
expression
signatures
(GES),
circulating
neutrophil-to-lymphocyte
ratio
(NLR),
indoleamine
2,3-dioxygenase
(IDO),
lymphocyte
activation
3
(LAG-3),
T
cell
immunoglobin
mucin
domain-containing
protein
(TIM-3),
TP53
mutation
status,
B
cells,
tertiary
lymphoid
structures
(TLS).
Finally,
TLS
both
prognostic
biomarker
ICI
be
implemented
clinic.
