Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Фев. 15, 2023
Lung
cancer
is
the
common
malignant
tumor
with
highest
mortality
rate.
patients
have
achieved
benefits
from
immunotherapy,
including
immune
checkpoint
inhibitors
(ICIs)
therapy.
Unfortunately,
acquire
adaptive
resistance,
leading
to
poor
prognosis.
Tumor
microenvironment
(TME)
has
been
demonstrated
play
a
critical
role
in
participating
acquired
resistance.
TME
associated
molecular
heterogeneity
of
immunotherapy
efficacy
lung
cancer.
In
this
article,
we
discuss
how
cell
types
are
correlated
Moreover,
describe
driven
gene
mutations
cancer,
KRAS,
TP53,
EGFR,
ALK,
ROS1,
KEAP1,
ZFHX3,
PTCH1,
PAK7,
UBE3A,
TNF-α,
NOTCH,
LRP1B,
FBXW7,
and
STK11.
We
also
emphasize
that
modulation
could
be
promising
strategy
for
improving
resistance
Frontiers in Cell and Developmental Biology,
Год журнала:
2022,
Номер
10
Опубликована: Май 12, 2022
As
one
of
the
main
appendages
skin,
hair
follicles
play
an
important
role
in
process
skin
regeneration.
Hair
follicle
is
a
tiny
organ
formed
by
interaction
between
epidermis
and
dermis,
which
has
complex
fine
structure
periodic
growth
characteristics.
The
cycle
divided
into
three
continuous
stages,
(anagen),
apoptosis-driven
regression
(catagen)
relative
quiescence
(telogen).
And
Morphogenesis
are
regulated
variety
signal
pathways.
When
molecules
pathways
abnormal,
it
will
affect
development
follicles,
lead
to
follicle-related
diseases.This
article
review
structure,
development,
molecular
regulation
order
provide
new
ideas
for
solving
diseases
forming
functional
follicle.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Авг. 7, 2024
Multicellular
organisms
are
composed
of
diverse
cell
types
that
must
coordinate
their
behaviors
through
communication.
Cell-cell
communication
(CCC)
is
essential
for
growth,
development,
differentiation,
tissue
and
organ
formation,
maintenance,
physiological
regulation.
Cells
communicate
direct
contact
or
at
a
distance
using
ligand-receptor
interactions.
So
cellular
encompasses
two
processes:
signal
conduction
generation
intercellular
transmission
signals,
transduction
reception
procession
signals.
Deciphering
networks
critical
understanding
metabolism.
First,
we
comprehensively
review
the
historical
milestones
in
CCC
studies,
followed
by
detailed
description
mechanisms
molecule
importance
main
signaling
pathways
they
mediate
maintaining
biological
functions.
Then
systematically
introduce
series
human
diseases
caused
abnormalities
progress
clinical
applications.
Finally,
summarize
various
methods
monitoring
interactions,
including
imaging,
proximity-based
chemical
labeling,
mechanical
force
analysis,
downstream
analysis
strategies,
single-cell
technologies.
These
aim
to
illustrate
how
functions
depend
on
these
interactions
complexity
regulatory
regulate
crucial
processes,
homeostasis,
immune
responses
diseases.
In
addition,
this
enhances
our
processes
occur
after
cell-cell
binding,
highlighting
its
application
discovering
new
therapeutic
targets
biomarkers
related
precision
medicine.
This
collective
provides
foundation
developing
targeted
drugs
personalized
treatments.
Acta Pharmaceutica Sinica B,
Год журнала:
2022,
Номер
12(10), С. 3877 - 3890
Опубликована: Май 26, 2022
Metastasis
is
crucial
for
the
mortality
of
non-small
cell
lung
carcinoma
(NSCLC)
patients.
The
epithelial-mesenchymal
transition
(EMT)
plays
a
critical
role
in
regulating
tumor
metastasis.
Glioma-associated
oncogene
1
(Gli1)
aberrantly
active
series
tissues.
However,
molecular
regulatory
relationships
between
Gli1
and
NSCLC
metastasis
have
not
yet
been
identified.
Herein,
we
reported
promoted
High
expression
was
associated
with
poor
survival
Ectopic
low
metastatic
A549
NCI-H460
cells
enhanced
their
migration,
invasion
abilities
facilitated
EMT
process,
whereas
knock-down
high
NCI-H1299
NCI-H1703
showed
an
opposite
effect.
Notably,
overexpression
accelerated
liver
intravenously
injected
model.
Further
research
that
positively
regulated
Snail
by
binding
to
its
promoter
enhancing
protein
stability,
thereby
facilitating
NSCLC.
In
addition,
administration
GANT-61,
inhibitor,
obviously
suppressed
Collectively,
our
study
reveals
regulator
suggests
targeting
prospective
therapy
strategy
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(2), С. 1321 - 1321
Опубликована: Янв. 10, 2023
Hedgehog–GLI
(HH)
signaling
plays
an
essential
role
in
embryogenesis
and
tissue
homeostasis.
Aberrant
activation
of
the
pathway
through
mutations
or
other
mechanisms
is
involved
development
progression
numerous
types
cancer,
including
basal
cell
carcinoma,
medulloblastoma,
melanoma,
breast,
prostate,
hepatocellular
pancreatic
carcinomas.
Activation
HH
sustains
proliferation,
suppresses
death
signals,
enhances
invasion
metastasis,
deregulates
cellular
metabolism
promotes
angiogenesis
tumor
inflammation.
Targeted
inhibition
has
therefore
emerged
as
attractive
therapeutic
strategy
for
treatment
a
wide
range
cancers.
Currently,
Smoothened
(SMO)
receptor
downstream
GLI
transcriptional
factors
have
been
investigated
targeted
drugs.
Recent
studies
revealed
that
also
immune
evasion
poor
responses
to
cancer
immunotherapy.
Here
we
focus
on
effects
major
components
adaptive
innate
systems,
present
recent
discoveries
elucidating
how
immunosuppressive
function
engaged
by
cells
prevent
surveillance.
In
addition,
discuss
future
prospect
options
combining
checkpoint
inhibitors.
Cell Proliferation,
Год журнала:
2021,
Номер
55(1)
Опубликована: Дек. 16, 2021
Abstract
Bone
formation
is
a
complex
regeneration
process
that
was
regulated
by
many
signalling
pathways,
such
as
Wnt,
Notch,
BMP
and
Hedgehog
(Hh).
All
of
these
have
been
demonstrated
to
participate
in
the
bone
repair
process.
In
particular,
one
promising
pathway
involved
homeostasis
Hh
pathway.
According
present
knowledge,
plays
vital
role
development
various
tissues
organs
embryo.
adults,
dysregulation
has
verified
be
bone‐related
diseases
terms
osteoarthritis,
osteoporosis
fracture;
during
processes,
could
reactivated
further
modulate
formation.
this
chapter,
we
summarize
our
current
understanding
on
function
homeostasis.
Additionally,
therapeutic
strategies
targeting
cascade
coordinate
mediate
osteogenesis
reviewed.
Molecular Biomedicine,
Год журнала:
2022,
Номер
3(1)
Опубликована: Дек. 15, 2022
Notch
and
Hedgehog
signaling
are
involved
in
cancer
biology
pathology,
including
the
maintenance
of
tumor
cell
proliferation,
stem-like
cells,
microenvironment.
Given
complexity
tumors,
its
role
as
both
a
promoter
suppressor,
crosstalk
between
pathways,
goal
developing
clinically
safe,
effective,
tumor-specific
Notch-targeted
drugs
has
remained
intractable.
Drugs
developed
against
pathway
have
affirmed
definitive
therapeutic
effects
basal
carcinoma;
however,
some
contexts,
challenges
resistance
recurrence
leap
to
forefront.
The
efficacy
is
very
limited
for
other
types.
In
recent
years,
we
witnessed
an
exponential
increase
investigation
recognition
critical
roles
pathways
cancers,
these
vast
space
value
explore.
A
series
clinical
trials
targeting
been
launched
continually.
this
review,
introduce
current
advances
understanding
specific
populations
microenvironments.
Moreover,
also
discuss
potential
therapy,
intending
promote
from
bench
bedside.
ACS Pharmacology & Translational Science,
Год журнала:
2023,
Номер
6(5), С. 671 - 682
Опубликована: Апрель 21, 2023
Breast
cancer
is
one
of
the
most
common
cancers
in
women
worldwide,
yet
conventional
treatments
have
several
shortcomings,
including
low
specificity,
systemic
toxicity,
and
drug
resistance.
Nanomedicine
technologies
provide
a
promising
alternative
while
also
overcoming
limitations
posed
by
therapies.
This
mini-Review
highlights
important
signaling
pathways
related
to
occurrence
development
breast
current
therapies,
followed
an
analysis
various
nanomedicine
developed
for
diagnosis
treatment
cancers.
