Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 53 - 69
Опубликована: Янв. 1, 2025
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(2), С. 1291 - 1291
Опубликована: Янв. 9, 2023
Nano-hydroxyapatite (n-HAp) is similar to human bone mineral in structure and biochemistry is, therefore, widely used as biomaterial a drug carrier. Further, n-HAp composite scaffolds have great potential role regeneration. Loading bioactive factors drugs onto composites has emerged promising strategy for defect repair tissue engineering. With local delivery of agents drugs, biological materials may be provided with the activity they lack improve This review summarizes classification composites, application loaded engineering loading methods scaffolds, research direction future prospected.
Язык: Английский
Процитировано
100
Pharmaceutics, Год журнала: 2022, Номер 14(8), С. 1748 - 1748
Опубликована: Авг. 22, 2022
Encompassing a group of complex and heterogeneous diseases, cancer continues to be challenge for patients healthcare systems worldwide. Thus, it is vital importance develop advanced treatment strategies that could reduce the trends cancer-associated morbidity mortality rates. Scientists have focused on creating performant delivery vehicles anti-cancer agents. Among possible materials, cyclodextrins (CDs) attracted increasing interest over past few years, leading emergence promising anti-tumor nanomedicines. Tackling their advantageous chemical structure, ease modification, natural origin, biocompatibility, low immunogenicity, commercial availability, researchers investigated CD-based therapeutical formulations against many types cancer. In this respect, in paper, we briefly present properties CDs designing nanocarriers, further reviewing some most recent potential applications management.
Язык: Английский
Процитировано
46
ONCOLOGIE, Год журнала: 2025, Номер unknown
Опубликована: Март 10, 2025
Язык: Английский
Процитировано
1
Carbohydrate Polymers, Год журнала: 2022, Номер 300, С. 120264 - 120264
Опубликована: Окт. 26, 2022
Язык: Английский
Процитировано
33
Critical Reviews in Oncology/Hematology, Год журнала: 2024, Номер 196, С. 104291 - 104291
Опубликована: Фев. 10, 2024
Язык: Английский
Процитировано
7
Materials, Год журнала: 2021, Номер 14(22), С. 6812 - 6812
Опубликована: Ноя. 11, 2021
Polymer-based nanoparticles of tailored size, morphology, and surface properties have attracted increasing attention as carriers for drugs, biomolecules, genes. By protecting the payload from degradation maintaining sustained controlled release drug, polymeric can reduce drug clearance, increase their cargo’s stability solubility, prolong its half-life, ensure optimal concentration at target site. The inherent immunomodulatory specific polymer nanoparticles, coupled with encapsulation ability, raised particular interest in vaccine delivery. This paper aims to review current emerging delivery applications both branched linear, natural, synthetic nanostructures, focusing on role development.
Язык: Английский
Процитировано
40
Drug Delivery, Год журнала: 2022, Номер 29(1), С. 1631 - 1647
Опубликована: Май 25, 2022
Primary bone tumors especially, sarcomas affect adolescents the most because it originates from osteoblasts cells responsible for growth. Chemotherapy, surgery, and radiation therapy are often used clinical treatments. Regrettably, surgical resection frequently fails to entirely eradicate tumor, which is primary cause of metastasis postoperative recurrence, leading a high death rate. Additionally, penetrate significant regions bone, rendering them incapable self-repair, impairing patients' quality life. As result, treating regenerating in clinic difficult. In recent decades, numerous sorts alternative approaches have been investigated due lack approved Among novel therapeutic approaches, hydrogel-based anticancer has cleared way development new targeted techniques cancer regeneration. They include strategies such as co-delivery several drug payloads, enhancing their biodistribution transport capabilities, normalizing accumulation, optimizing release profiles decrease limitations current therapy. This review discusses advances functionalized hydrogels develop technique by reducing tumor recurrence promoting tissue repair.
Язык: Английский
Процитировано
27
Free Radical Biology and Medicine, Год журнала: 2022, Номер 189, С. 32 - 41
Опубликована: Июль 14, 2022
High-dose systemic chemotherapy constitutes a main strategy in the management of bone metastases, employing drugs like doxorubicin (DOX), related with severe side effects. To solve this issue, Cold Atmospheric Plasmas (CAP) have been proposed as potential non-invasive anti-cancer agents capable improving efficacy traditional drugs. Here, we investigate cytotoxic effects Plasma Conditioned Medium (PCM) combination DOX prostate cancer cells from metastases (PC-3) well non-malignant bone-cells. PCM was able to enhance both monolayer and 3D bioengineered model mimicking matrix. The combined treatment + resulted profound downregulation redox defenses (CAT1, SOD2, GPX1) drug resistance genes (MRP1, MDR1, BCRP1), resulting an enhanced uptake coupled overload intracellular ROS. Besides, improved interfering on migratory clonogenic PC-3 cells. Importantly, were unaffected by DOX. Overall, these new findings may represent therapeutic approach for metastatic future.
Язык: Английский
Процитировано
26
Molecules, Год журнала: 2023, Номер 28(2), С. 841 - 841
Опубликована: Янв. 14, 2023
The blood–brain barrier (BBB) serves as a protective for the central nervous system (CNS) against drugs that enter bloodstream. BBB is key clinical in treatment of CNS illnesses because it restricts drug entry into brain. To bypass this and release relevant brain matrix, nanotechnology-based delivery systems have been developed. Given unstable nature NPs, an appropriate amount biocompatible polymer coating on NPs thought to role reducing cellular cytotoxicity while also boosting stability. Human serum albumin (HSA), poly (lactic-co-glycolic acid) (PLGA), Polylactide (PLA), (alkyl cyanoacrylate) (PACA), gelatin, chitosan are only few significant polymers mentioned. In review article, we categorized polymer-coated nanoparticles from basic complex discussed their application novel carriers
Язык: Английский
Процитировано
16
Scientific Reports, Год журнала: 2023, Номер 13(1)
Опубликована: Апрель 25, 2023
Bone cancer has traditionally been treated using surgery, radiotherapy, and/or chemotherapy. The nonspecific distribution of chemotherapy and implantable infections are significant risk factors for the failure bone to heal. Multifunctional zinc silver co-doped bioactive glass nanoparticles (yAg-xZn-BGNPs) with a diameter 150 ± 30 nm were successfully synthesized modified sol-gel two-step post-functionalization processes, tailored provide antibacterial anticancer activity whilst maintaining osteogenesis ability. Co-doped BGNPs Zn Ag did not significantly alter physicochemical properties, including size, morphology, network, amorphous nature. Apatite-like layer was observed on surface yAg-xZn-BGNPs resorbed in simulated body fluid solution, which could increase their bioactivity. Human fetal osteoblast cell line (hFOB 1.19) particles showed calcified tissue formation alkaline phosphatase absence osteogenic supplements vitro, especially 0.5Ag-1Zn-BGNPs. Moreover, these preferentially disrupted metabolic cells (MG-63) had an effect against B. subtilis, E. coli, S. aureus via disc diffusion method. This novel 0.5Ag-1Zn-BGNP 1Ag-1Zn-BGNPs, wide-ranging ability stimulate regeneration, inhibit proliferation, prevent bacterial growth may feasible strategy treatment. 0.5Ag-1Zn-BGNPs 1Ag-1Zn-BGNPs can be applied preparation scaffolds or filler composites engineering.
Язык: Английский
Процитировано
16