Starting points for the development of new targeted therapies for glioblastoma multiforme

Translational Oncology, Год журнала: 2024, Номер 51, С. 102187 - 102187

Опубликована: Ноя. 11, 2024

Язык: Английский

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The Precision Oncology Approach to Molecular Cancer Therapeutics Targeting Oncogenic Signaling Pathways is a Means to an End

Опубликована: Янв. 23, 2024

Cancer is a deadly genetic disease with diverse aspects of complexity, including cancer immune evasion, treatment resistance, and recurrence requiring optimized to be cured. Molecular studies have revealed that tumors are profoundly heterogeneous in nature, leading the complexity progression ultimately linked its machinery. It important note patients same types respond differently treatments, indicating need for patient-specific options. This requires an in-depth genomic study patient's fully understand driving factors effective targeted therapy. Precision oncology has evolved as form therapy focused on profiling identify molecular alterations involved development tailored individualized disease. Whole genome sequencing, tumor cell-free DNA profiling, transcriptomics, proteomics exploration system basis this field research treatment. article aims briefly explain foundations frontiers precision context ongoing technological advancements related fields assess scope importance achieving cure against cancer.

Язык: Английский

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Targeted Therapy with Polymeric Nanoparticles in PBRM1-Mutant Biliary Tract Cancers: Harnessing DNA Damage Repair Mechanisms

Critical Reviews in Oncology/Hematology, Год журнала: 2024, Номер 204, С. 104505 - 104505

Опубликована: Сен. 8, 2024

Язык: Английский

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Detection of pan-cancer surface protein biomarkers via a network-based approach on transcriptomics data

Briefings in Bioinformatics, Год журнала: 2022, Номер 23(5)

Опубликована: Авг. 24, 2022

Cell surface proteins have been used as diagnostic and prognostic markers in cancer research targets for the development of anticancer agents. Many these lie at top signaling cascades regulating cell responses gene expression, therefore acting 'signaling hubs'. It has previously demonstrated that integrated network analysis on transcriptomic data is able to infer protein activity breast cancer. Such an approach implemented a publicly available method called 'SURFACER'. SURFACER implements network-based focusing overall curated proteins, with final aim identify those driving major phenotypic changes level, named hubs. Here, we show ability discover relevant knowledge within across datasets. We also how different cancers can be stratified surface-activity-specific groups. Our strategy may cancer-wide design targeted therapies biomarker-based approaches.

Язык: Английский

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Biomarkers in the Era of Precision Oncology

Cancers, Год журнала: 2023, Номер 15(6), С. 1782 - 1782

Опубликована: Март 15, 2023

Cancer heterogeneity provides a formidable obstacle to optimizing clinical protocols achieve durable responses [...]

Язык: Английский

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The Precision Oncology Approach to Molecular Cancer Therapeutics Targeting Oncogenic Signaling Pathways is a Means to an End

SSRN Electronic Journal, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Cancer is a deadly genetic disease with diverse aspects of complexity, including cancer immune evasion, treatment resistance, and recurrence requiring optimized to be cured. Molecular studies have revealed that tumors are profoundly heterogeneous in nature, leading the complexity progression ultimately linked its machinery. It important note patients same types respond differently treatments, indicating need for patient-specific options. This requires an in-depth genomic study patient's fully understand driving factors effective targeted therapy. Precision oncology has evolved as form therapy focused on profiling identify molecular alterations involved development tailored individualized disease. Whole genome sequencing, tumor cell-free DNA profiling, transcriptomics, proteomics exploration system basis this field research treatment. article aims briefly explain foundations frontiers precision context ongoing technological advancements related fields assess scope importance achieving cure against cancer.

Язык: Английский

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The Precision Oncology Approach to Molecular Cancer Therapeutics Targeting Oncogenic Signaling Pathways is a Means to an End

Опубликована: Янв. 25, 2024

Cancer is a fatal genetic disease with different aspects of complexity, including cancer immune evasion, treatment resistance and recurrence, requiring optimized for proper cure. Molecular studies have revealed that tumors are hugely heterogeneous in nature, leading to the complexity progression ultimately linked its machinery. In recent decades, there has been deluge large-scale production anticancer agents, primarily due advances genomic technologies enabling precise targeting oncogenic pathways involved development. It important note patients same types respond differently treatments, indicating need patient-specific options. An in-depth study will be needed fully understand driving factors initiation effective targeted therapy. Precision oncology evolved as form therapy focused on profiling patients’ identify molecular alterations manifestation tailored individualized disease. This article aims briefly explain foundations frontiers precision review tools techniques process assess scope importance achieving cures against cancer.

Язык: Английский

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Targeting Cancer Cell Signaling Using Precision Oncology Towards a Holistic Approach to Cancer Therapeutics

Опубликована: Фев. 7, 2024

Cancer is a complex and multifaceted disease having number of composite problems to be considered including cancer immune evasion, therapy resistance, recurrence for prevention cure. Fundamentally it remains genetic as diverse aspects the complexity tumor growth development relate its machinery requires addressing at level genome epigenome. Presumably, mutational changes occurring in regulatory genes responsible maintaining optimal cell growth, proliferation, differentiation gradually lead progression metastasis. Importantly, patients with same types respond differently therapies, indicating need patient-specific treatment option Precision oncology form that focuses on profiling individual tumors identify molecular alterations involved custom-tailored personalized disease. It rely upon genomic study cells get clear picture prognosis pathways look means selectively target them ensure effective deadly now combines diagnosis followed by designing regimen precise different stages times. Recent advances technologies have indeed accelerated implementation precision management, leading improved clinical outcomes selected cohorts patients. This article aims briefly explain foundations frontiers context ongoing technological this regard assess scope importance realization proper cure cancer.

Язык: Английский

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Precision Oncology, Signaling Pathways Reprogramming and Targeted Therapy: A Holistic Approach to Molecular Cancer Therapeutics

Опубликована: Май 6, 2024

Cancer is a fatal genetic disease with different aspects of complexity, including cancer immune evasion, treatment resistance and recurrence, requiring optimized for proper cure. Molecular studies have revealed that tumors are extremely heterogeneous in nature, leading to the complexity progression ultimately linked its machinery. It important note patients same types respond differently treatments, indicating need options specific each patient. Thus, in-depth genomic study patient’s tumor will be needed fully understand determinants initiation effective targeted therapy. Precision oncology has evolved as form therapy focused on profiling identify molecular alterations involved manifestation tailored individualized disease. There been deluge formulation mass production anticancer agents recent years, mainly due advances technologies enabling precise targeting oncogenic pathways This article aims briefly explain foundations frontiers precision context advancements tools techniques exploited process order assess scope importance realize intended goals.

Язык: Английский

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Precision Oncology, Cell Signaling and Targeted Therapy: A Holistic Approach to Molecular Cancer Therapeutics

Опубликована: Май 13, 2024

Cancer is a fatal genetic disease with different aspects of complexity, including cancer immune evasion, treatment resistance and recurrence, requiring optimized for proper cure. Molecular studies have revealed that tumors are extremely heterogeneous in nature, leading to the complexity progression ultimately linked its machinery. It important note patients same types respond differently treatments, indicating need options specific each patient. Thus, in-depth genomic study patient’s tumor will be needed fully understand determinants initiation effective targeted therapy. Precision oncology has evolved as form therapy focused on profiling identify molecular alterations involved manifestation tailored individualized disease. There been deluge formulation mass production anticancer agents recent years, mainly due advances technologies enabling precise targeting oncogenic pathways This article aims briefly explain foundations frontiers precision context advancements tools techniques exploited process order assess scope importance realize intended goals.

Язык: Английский

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