Pioneering molecular screening for cervical precursor lesions and cervical cancer in sera

Frontiers in Oncology, Год журнала: 2024, Номер 14

Опубликована: Ноя. 14, 2024

Cervical cancer is a significant public health issue in Mexico and many developing countries. Early detection crucial for combating this disease. The official screening test cervical cytology, but technique faces several barriers, including methodological, educational, sociocultural challenges. Liquid-based cytology an improved version of test, however it does not address the aforementioned complications. Biomarkers precursor lesions can improve timely A previous study from our group identified four circulating human proteins as potential biomarkers these conditions. For molecular screening, we selected GAPDH biomarker HNRNPA1 -chosen three previously options based on antibody availability- to be detected sera. Participants underwent comprehensive panel tests, liquid-based PCR Human papillomavirus (HPV), colposcopy, histopathology -when applicable-. last two tests were used references determining sensitivity specificity, with being gold standard diagnosis. All participants successfully received colposcopies (n = 99) only those women visible or suspected lesions/malignancies biopsied 62). subset randomly biopsies p16 INK4a immunohistochemistry 36). This compares performance screening. With colposcopy reference, showed 30% 96% while 90% 43% specificity. 21% 93% 85% 61% outperformed areas, detecting true-positive cases, reducing false-negative cases by 34.62%, application time, simplicity result´s categories, acceptance among participants. An ideal requires high sensitivity, maintains moderate minimizes false negatives. Our proposed meets criteria, making complement -or alternative-

Язык: Английский

Disruption of CADM1-dependent cell-cell adhesion in human oral squamous cell carcinoma cells results in tumor progression, possibly through an increase of MMP-2 and MMP-9 expression

Journal of Oral Biosciences, Год журнала: 2023, Номер 66(1), С. 151 - 159

Опубликована: Ноя. 28, 2023

Язык: Английский

Therapies in Cervical Cancer—Editorial

Cancers, Год журнала: 2023, Номер 15(2), С. 537 - 537

Опубликована: Янв. 16, 2023

George Papanikolaou is famously quoted as saying "the first observation of cancer cells in the smear uterine cervix gave me one greatest thrills I ever experienced during my scientific career" [...].

Язык: Английский