DIA/SWATH-Mass Spectrometry Revealing Melanoma Cell Proteome Transformations with Silver Nanoparticles: An Innovative Comparative Study DOI Open Access
Simona Martano, Jakub Faktor, Sachin Kote

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 2029 - 2029

Опубликована: Фев. 26, 2025

Melanoma is an aggressive cancer with rising incidence and high mortality rates, largely due to chemotherapy resistance molecular dysregulation. Nanotechnology, particularly silver nanoparticles (AgNPs), has emerged as a promising therapeutic avenue because of the nanoparticles' ability induce oxidative stress apoptosis in cells. However, conventional colloidal AgNPs lack selectivity, often causing significant damage healthy In this study, we introduce green synthesis using plant extracts, providing eco-friendly alternative improved antitumor selectivity compared traditional AgNPs. Leveraging label-free Data-Independent Acquisition/Sequential Window Acquisition All Theoretical Mass Spectrometry (DIA/SWATH MS) quantitative proteomics, investigated effects green-synthesized versus on A375 melanoma cells at 24 48 h. Our findings reveal that selectively reduced cell viability while sparing keratinocytes (HaCaT), benefit not observed Proteomic analysis highlighted significantly downregulated oncogenes, enhanced carbohydrate metabolism, disrupted copper homeostasis This marks first study explore differential integrated proteomic approach, underscoring potential targeted sustainable option for therapy.

Язык: Английский

Development of curcumin-loaded ultra deformable lipid vesicles for enhanced anti-melanoma activity: in vitro, ex-vivo, and cell line studies DOI
Malleswara Rao Peram, S. Vidyadhara, S. R. Patil

и другие.

Journal of Dispersion Science and Technology, Год журнала: 2025, Номер unknown, С. 1 - 18

Опубликована: Фев. 4, 2025

Язык: Английский

Процитировано

0
Enhanced delivery of Dacarbazine using Nanosponge loaded Hydrogel for Targeted Melanoma Treatment: Formulation, Statistical Optimization and Pre-clinical Evaluation DOI

Sarah Vankudre,

Nisha Shirkoli, Ranjit Hawaldar

и другие.

Journal of Pharmaceutical Innovation, Год журнала: 2025, Номер 20(1)

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Epidemiological Characteristics and Temporal Trends of Malignant Melanoma from 1990 to 2021, with Projections until 2044 DOI Creative Commons
Ling Yao, Yonghai Li,

H H Li

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Фев. 6, 2025

Abstract OBJECTIVE Malignant melanoma, one of the most metastatic human cancers, is on rise globally. However, its low prevalence leads to insufficient concern and latest worldwide burden remains unclear. This study aims update epidemiological features prompt timely impactful interventions. METHODS Weanalysed malignant melanoma incidence, disability-adjusted life years (DALYs), mortality trends from 1990 2021 across 204 countries using GBD data. We also projected incidence rates for next two decades. RESULTS Globally, age-standardized rate (ASIR) in was 3.6 per 100,000 people with estimated annual percentage change (EAPC) ASIR 1990–2021 0.6%. The DALYs (ASDR) 19.6 ASDR EAPC -0.7%. rate（ASMR）of 0.7 ASMR -0.4%. Australia remained region highest ASIR, ASDR, 2021. Older adult males had higher than females all three measures. MM predicted remain stable over twenty while will significantly decline. CONCLUSION global increased 2021, decreased during same period. High-SDI older require enhanced measures prevention control melanoma.

Язык: Английский

Процитировано

0
Clinical and histopathological melanoma correlates: staging associations and prognostic implications DOI

Hadiya Sibghatullah,

Sibghatullah Sangi,

Safdar Ali Shaikh

и другие.

Journal Of Advanced Pharmacy Education And Research, Год журнала: 2025, Номер 15(1), С. 84 - 89

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
DIA/SWATH-Mass Spectrometry Revealing Melanoma Cell Proteome Transformations with Silver Nanoparticles: An Innovative Comparative Study DOI Open Access
Simona Martano, Jakub Faktor, Sachin Kote

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 2029 - 2029

Опубликована: Фев. 26, 2025

Melanoma is an aggressive cancer with rising incidence and high mortality rates, largely due to chemotherapy resistance molecular dysregulation. Nanotechnology, particularly silver nanoparticles (AgNPs), has emerged as a promising therapeutic avenue because of the nanoparticles' ability induce oxidative stress apoptosis in cells. However, conventional colloidal AgNPs lack selectivity, often causing significant damage healthy In this study, we introduce green synthesis using plant extracts, providing eco-friendly alternative improved antitumor selectivity compared traditional AgNPs. Leveraging label-free Data-Independent Acquisition/Sequential Window Acquisition All Theoretical Mass Spectrometry (DIA/SWATH MS) quantitative proteomics, investigated effects green-synthesized versus on A375 melanoma cells at 24 48 h. Our findings reveal that selectively reduced cell viability while sparing keratinocytes (HaCaT), benefit not observed Proteomic analysis highlighted significantly downregulated oncogenes, enhanced carbohydrate metabolism, disrupted copper homeostasis This marks first study explore differential integrated proteomic approach, underscoring potential targeted sustainable option for therapy.

Язык: Английский

Процитировано

0