Antioxidants,
Год журнала:
2023,
Номер
12(10), С. 1845 - 1845
Опубликована: Окт. 11, 2023
Several
studies
report
that
breast
cancer
survivors
(BCS)
tend
to
have
a
poor
diet,
as
fruit,
vegetable,
and
legume
consumption
is
often
reduced,
resulting
in
decreased
intake
of
nutraceuticals.
Moreover,
weight
gain
has
been
commonly
described
among
BCS
during
treatment,
increasing
recurrence
rate
mortality.
Improving
lifestyle
nutrition
after
the
diagnosis
BC
may
important
benefits
on
patients’
general
health
specific
clinical
outcomes.
The
Mediterranean
diet
(MD),
known
for
its
multiple
beneficial
effects
health,
can
be
considered
nutritional
pool
comprising
several
nutraceuticals:
bioactive
compounds
foods
with
anti-inflammatory
antioxidant
effects.
Recent
scientific
advances
led
identification
nutraceuticals
could
amplify
MD
favorably
influence
gene
expression
these
patients.
Nutraceuticals
postdiagnostic
phase
BC,
including
helping
mitigate
adverse
chemotherapy
radiotherapy.
valid
easy-to-follow
option
managing
excess
weight.
aim
this
narrative
review
evaluate
recent
literature
possible
consuming
functional
nutraceutical
framework
BCS.
Biomedicines,
Год журнала:
2025,
Номер
13(2), С. 422 - 422
Опубликована: Фев. 10, 2025
The
intricate
relationship
between
anticancer
drugs
and
the
gut
microbiome
influences
cancer
treatment
outcomes.
This
review
paper
focuses
on
role
of
integrity
in
enhancing
efficacy
safety
drug
therapy,
emphasizing
pharmacokinetic
interactions
microbiota.
It
explores
how
disruptions
to
composition,
or
dysbiosis,
can
alter
metabolism,
immune
responses,
side
effects.
By
examining
mechanisms
disruption
caused
by
drugs,
this
highlights
specific
case
studies
like
cyclophosphamide,
5-fluorouracil,
irinotecan,
their
impact
microbial
diversity
clinical
also
discusses
microbiome-targeted
strategies,
including
prebiotics,
probiotics,
postbiotics,
fecal
microbiota
transplantation
(FMT),
as
promising
interventions
enhance
treatment.
Furthermore,
potential
profiling
personalizing
therapy
integrating
these
into
practice
is
explored.
Finally,
proposes
future
research
directions,
developing
novel
biomarkers
a
deeper
comprehension
drug-microbiome
interactions,
respond
current
gaps
knowledge
improve
patient
outcomes
care.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 24, 2025
Abstract
Breast
cancer
is
a
widespread
with
high
death
rate
globally.
The
incidence
of
breast
expected
to
increase,
particularly
in
low
and
middle-income
countries
due
environmental
factors
lifestyle
changes.
Several
risk
factors,
such
as
age,
family
history,
hormonal
reproductive
have
been
identified
influence
development.
Metabolic
syndrome,
metabolic
disorder
that
has
also
linked
risk.
gut
microbiome
suggested
one
the
leading
cancer.
human
mainly
colonized
intestine
by
various
bacterial
species,
including
Lactobacillus
,
Bifidobacterium
Streptococcus
protect
host
against
pathogenic
microorganisms
regulate
immune
system.
This
study
included
50
female
patients
healthy
controls
matched
ages.
Stool
fresh
samples
were
taken
from
test
control
groups
stored
at
−
20
°C
until
further
investigations.
DNA
bacteria
stool
was
extracted
using
reverse
transcription-quantitative
polymerase
chain
reaction
check
for
16s
rRNA
gene.
exclusion
criteria
other
malignancies,
recent
intestinal
surgery,
infectious
diarrhea,
prolonged
use
antibiotics,
substance
addiction,
pregnancy
or
lactation.
Our
findings
exhibited
had
higher
syndrome
(60%)
compared
cancer-free
(40%).
Furthermore,
significantly
lower
counts
than
controls.
No
significant
difference
found
between
groups.
These
support
relationship
suggest
potential
involvement
pathophysiology.
supports
relation
suggests
Further
research
necessary
investigate
complex
interactions
genes,
environment,
Understanding
these
could
lead
progress
novel
strategies
prevention
treatment.
iScience,
Год журнала:
2024,
Номер
27(6), С. 109893 - 109893
Опубликована: Май 3, 2024
Recent
advances
in
cancer
research
have
unveiled
a
significant
yet
previously
underappreciated
aspect
of
oncology:
the
presence
and
role
intratumoral
microbiota.
These
microbial
residents,
encompassing
bacteria,
fungi,
viruses
within
tumor
tissues,
been
found
to
exert
considerable
influence
on
development,
progression,
efficacy
therapeutic
interventions.
This
review
aims
synthesize
these
groundbreaking
discoveries,
providing
an
integrated
overview
identification,
characterization,
functional
roles
microbiota
biology.
We
focus
elucidating
complex
interactions
between
microorganisms
microenvironment,
highlighting
their
potential
as
novel
biomarkers
targets.
The
purpose
this
is
offer
comprehensive
understanding
dimension
cancer,
paving
way
for
innovative
approaches
diagnosis
treatment.
Life,
Год журнала:
2023,
Номер
13(7), С. 1466 - 1466
Опубликована: Июнь 28, 2023
Alzheimer’s
disease
(AD)
is
characterized
by
the
accumulation
of
specific
proteins
in
brain.
A
recent
study
revealed
that
manipulating
gut
microbiota
(GM)
significantly
reduced
tau
pathology
and
neurodegeneration
an
apolipoprotein
E
isoform-dependent
manner.
The
resilience
a
healthy
protects
it
from
variety
dysbiosis-related
pathologies.
Convincing
evidence
has
demonstrated
roles
GM
pathogenesis
AD,
which
are
partly
mediated
modified
microglial
activity
Therefore,
modulation
may
be
promising
therapeutic
option
for
AD
prevention.
In
addition
to
providing
cells
with
energy
affecting
maturation,
these
microbial
metabolites
appear
influence
neuronal
function.
One
potential
approaches
targeting
involve
using
probiotics.
Additionally,
human
its
have
also
become
targets
developing
interventions
prevention
disorders.
Synbiotics
postbiotics
can
used
treat
modulating
GM.
addition,
physical
activity,
exercise,
fitness
being
considered
as
nonpharmacological
therapies
reduce
signaling
pathways
related
neuroinflammation.
might
strategies
health
promotion.
Clinical & Translational Oncology,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 18, 2024
Abstract
Breast
cancer
(BC)
is
one
of
the
most
diagnosed
cancers
in
women.
Based
on
histological
characteristics,
they
are
classified
as
non-invasive,
or
situ
(tumors
located
within
milk
ducts
lobules)
and
invasive.
BC
may
develop
from
carcinomas
over
time.
Determining
prognosis
predicting
response
to
treatment
essential
tools
manage
this
disease
reduce
its
incidence
mortality,
well
promote
personalized
therapy
for
patients.
However,
half
cases
not
associated
with
known
risk
factors.
In
addition,
some
patients
resistance
relapse.
Therefore,
it
necessary
identify
new
biomarkers
strategies
that
improve
existing
therapies.
regard,
role
microbiome
being
researched
could
play
a
carcinogenesis
efficacy
This
review
aims
describe
specific
patterns
BC.
For
this,
literature
search
was
carried
out
PubMed
database
using
MeSH
terms
“Breast
Neoplasms”
“Gastrointestinal
Microbiome”,
including
29
publications.
Most
studies
have
focused
characterizing
gut
breast
tissue
Likewise,
animal
models
vitro
investigated
impact
microbiota
(GM)
treatments
effects
tumor
cells
were
included.
results
included
articles,
be
an
imbalance
GM.
varied
depending
molecular
type,
stage
grade
cancer,
menopause,
menarche,
body
mass
index,
physical
activity.
microbial
profile
identified
biomarker.
On
other
hand,
suggest
GM
influence
microorganisms
bacterial
metabolites
therapies
development.
Metabolites,
Год журнала:
2023,
Номер
13(6), С. 703 - 703
Опубликована: Май 28, 2023
The
most
common
cancer
in
women
is
breast
cancer,
which
also
the
second
leading
cause
of
death
this
group.
It
is,
however,
important
to
note
that
some
will
develop
or
not
regardless
whether
certain
known
risk
factors
are
present.
On
other
hand,
compounds
produced
by
bacteria
gut,
such
as
short-chain
fatty
acids,
secondary
bile
and
metabolites
may
be
linked
development
mediate
chemotherapy
response.
Modeling
microbiota
through
dietary
intervention
identifying
directly
associated
with
its
complications
useful
identify
actionable
targets
improve
effect
antiangiogenic
therapies.
Metabolomics
therefore
a
complementary
approach
metagenomics
for
purpose.
As
result
combination
both
techniques,
better
understanding
molecular
biology
oncogenesis
can
obtained.
This
article
reviews
recent
literature
about
influence
bacterial
patients,
well
diet.
