Thermal effects and biological response of breast and pancreatic cancer cells undergoing gold nanorod-assisted photothermal therapy
Journal of Photochemistry and Photobiology B Biology,
Год журнала:
2024,
Номер
259, С. 112993 - 112993
Опубликована: Июль 20, 2024
Язык: Английский
Numerical study of the induction of intratumoral apoptosis under microwave ablation by changing slot length of microwave coaxial antenna
Medical & Biological Engineering & Computing,
Год журнала:
2024,
Номер
62(7), С. 2177 - 2187
Опубликована: Март 15, 2024
Язык: Английский
Evaluation of the equivalent thermal dose and power requirement for pulsed hyperthermia
Thermal Science and Engineering Progress,
Год журнала:
2024,
Номер
50, С. 102586 - 102586
Опубликована: Апрель 17, 2024
Язык: Английский
Thermosensitive Liposomes for Gemcitabine Delivery to Pancreatic Ductal Adenocarcinoma
Cancers,
Год журнала:
2024,
Номер
16(17), С. 3048 - 3048
Опубликована: Сен. 1, 2024
Treatment
of
pancreatic
ductal
adenocarcinoma
with
gemcitabine
is
limited
by
an
increased
desmoplasia,
poor
vascularization,
and
short
plasma
half-life.
Heat-sensitive
liposomes
modified
polyethylene
glycol
(PEG;
PEGylated
liposomes)
can
increase
stability,
reduce
clearance,
decrease
side
effects.
Nevertheless,
translation
heat-sensitive
to
the
clinic
has
been
hindered
low
loading
efficiency
difficulty
inducing
hyperthermia
in
vivo.
This
study
was
designed
investigate
effect
phospholipid
content
on
stability
at
37
°C
their
release
under
conditions;
this
accomplished
employing
a
two-stage
heating
approach.
First
were
heated
fast
rate,
then
they
transferred
holding
bath.
Thermosensitive
formulated
DPPC:
DSPC:
PEG2k
(80:15:5,
mole%)
exhibited
minimal
carboxyfluorescein
over
30
min,
indicating
physiological
conditions.
However,
upon
exposure
hyperthermic
conditions
(43
45
°C),
these
demonstrated
rapid
significant
encapsulated
content.
The
encapsulation
for
calculated
16.9%.
Additionally,
fluorescent
analysis
during
removal
unencapsulated
revealed
pH.
In
vitro
tests
BxPC3
KPC
cell
models
showed
that
thermosensitive
induced
heat-dependent
cytotoxic
comparable
free
temperatures
above
41
°C.
highlights
effectiveness
mechanism
understanding
current
challenges
developing
gemcitabine-loaded
liposomes.
Язык: Английский
Protocol for building a user-friendly temperature control system to support microscopes, microfluidic chambers, and custom incubators
STAR Protocols,
Год журнала:
2024,
Номер
5(1), С. 102862 - 102862
Опубликована: Янв. 30, 2024
Biological
experiments
require
precise
temperature
control,
necessitating
an
integrated
adjustable
system
for
instruments
such
as
microscopes,
microfluidic
chambers,
or
custom
incubators.
We
present
a
protocol
building
user-friendly
control
suitable
both
in
vitro
and
vivo
assays.
describe
steps
preparing
materials,
assembling
the
printed
circuit
board
enclosure,
fine-tuning
heating
algorithm
accuracy.
This
can
maintain
stable
of
up
to
60°C
with
stabilities
under
0.06°C.
Язык: Английский
Studies on the thermal sensitivity of lung cancer cells exposed to an alternating magnetic field and magnesium-doped maghemite nanoparticles
Cancer Nanotechnology,
Год журнала:
2024,
Номер
15(1)
Опубликована: Июль 22, 2024
Abstract
Background
Magnetic
fluid
hyperthermia
(MFH)
represents
a
promising
therapeutic
strategy
in
cancer
utilizing
the
heating
capabilities
of
magnetic
nanoparticles
when
exposed
to
an
alternating
field
(AMF).
Because
efficacy
and
safety
MFH
treatments
depends
on
numerous
intrinsic
extrinsic
factors,
therefore,
proper
setups
should
focus
thermal
energy
dosed
into
cells.
Methods
In
this
study,
we
performed
experiments
using
human
lung
A549
cells
(in
vitro)
NUDE
Balb/c
mice
bearing
(A549)
vivo).
these
two
experimental
models,
heat
was
induced
by
magnesium-doped
iron(III)
oxide
coated
with
mPEG-silane
(Mg
0.1
-γ-Fe
2
O
3
(mPEG-silane)
0.5
)
AMF.
Results
We
observed
that
treated
Mg
(0.25
mg·mL
−1
magnetized
for
30
min
at
14.4
kA·m
yielded
satisfactory
outcome
reducing
cell
viability
up
ca.
21%
vitro).
The
activation
calculated
strength
estimated
349
kJ·mol
.
Both
volumetric
measurements
tumor
mass
assessments
confirmed
resonance
imaging
(MRI)
showed
superior
effect
injected
intratumorally
(3
subjected
AMF
(18.3
four
times
weekly
intervals.
Research
demonstrated
undergoing
exhibited
marked
suppression
growth
(V
=
169
±
94
mm
;
p
<
0.05)
comparison
control
group
untreated
mice.
CEM43
(cumulative
number
equivalent
minutes
43
°C)
value
were
9.6
specific
absorption
rate
(SAR)
level
ranging
from
100
150
W·g
Conclusions
as-obtained
results,
both
cytotoxic
those
related
calculations
SAR,
may
contribute
advancement
therapies,
concurrently
indicating
proposed
holds
great
potential
further
testing
context
medical
applications.
Graphical
Язык: Английский
Personalized Plasma Medicine for Cancer: Transforming Treatment Strategies with Mathematical Modeling and AI Algorithms
Опубликована: Авг. 22, 2023
Plasma
technology
shows
tremendous
potential
for
revolutionizing
oncology
research
and
treatment.
Reactive
oxygen
nitrogen
species,
electromagnetic
emissions
generated
through
gas
plasma
jets,
have
attracted
significant
attention
due
to
their
selective
cytotoxicity
towards
cancer
cells.
To
leverage
the
full
of
medicine,
researchers
explored
use
mathematical
models
various
subsets
machine
learning,
such
as
reinforcement
deep
learning.
This
review
emphasizes
application
AI
algorithms
in
adaptive
system,
paving
way
precision
dynamic
Realizing
requires
efforts,
data
sharing
interdisciplinary
collaborations.
Unravelling
complex
mechanisms,
developing
real-time
diagnostics,
optimizing
will
be
crucial
harness
true
power
oncology.
The
integration
personalized
therapies,
alongside
diagnostic
sensors,
presents
a
transformative
approach
treatment
with
improve
outcomes
globally.
Язык: Английский