Clinical Kidney Journal, Год журнала: 2023, Номер 17(1)
Опубликована: Дек. 9, 2023
Язык: Английский
Computers in Biology and Medicine, Год журнала: 2023, Номер 165, С. 107356 - 107356
Опубликована: Авг. 14, 2023
Язык: Английский
Процитировано
71
British Journal of Cancer, Год журнала: 2024, Номер 130(7), С. 1078 - 1082
Опубликована: Фев. 29, 2024
Abstract Cancer research has played a pivotal role in improving patient outcomes. However, despite the significant investment fundamental cancer over past few decades, translation of funding into substantial advancements treatment been limited. This perspective article employs detailed analysis to outline strategies for promoting innovation and facilitating discoveries within field research.
Язык: Английский
Процитировано
15
TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 177, С. 117783 - 117783
Опубликована: Май 21, 2024
In the field of cancer detection, development affordable, quick, and user-friendly sensors capable detecting various biomarkers, including those for lung (LC), holds utmost significance. Sensors are expected to play a crucial role in early-stage diagnosis diseases. Among range options, emerge as particularly appealing diseases, owing their cost-effectiveness, simplicity, promising analytical performance. There is growing interest application molecularly imprinted polymers (MIPs) recognition elements gas sensors. MIPs, leading technology sensing analytes where no suitable bioreceptor exists, commonly used artificial that can be applied key fields like early disease diagnostics, based on detection volatile biomarkers. an extensive demand early, non-invasive diseases self-monitoring health conditions. Detection biomarkers point-of-care mode remains challenging limited by factors. Hence, breath analysis has received enormous attention healthcare due its relatively low cost, sampling method, rapid capabilities. The latest developments MIP-based utility through comprehensively critically evaluated this review. Furthermore, challenges perspectives elaborated upon, with view towards introduction market successful commercialization.
Язык: Английский
Процитировано
8
Archives of Pediatrics and Pediatric Surgery, Год журнала: 2025, Номер 2(3), С. 4 - 9
Опубликована: Фев. 3, 2025
A team of authors have conducted a study on the influence multifactorial diseases relatives three generations two lines descent formation perinatal pathology in children. To conduct study, special questionnaire was developed, consisting 8 blocks, one which allows to identify family problems. The analysis data obtained showed that an unfavorable period parents increases risk having child with pathology, and history preterm birth frequency premature child. revealed highest impact development adulthood is exerted by health disorders period, such as prematurity, intrauterine hypoxia/asphyxia during childbirth, respiratory trauma. In turn, relatives, among most common are hypertension (18.7%), coronary heart disease (17.3%) gastric ulcer (10.5%) burden increasing from generation generation, serves factor for pathology.
Язык: Английский
Процитировано
0
ACS Sensors, Год журнала: 2025, Номер unknown
Опубликована: Фев. 17, 2025
This study focuses on the surface functionalization of citrate-stabilized gold nanoparticles (AuNPs) with disease-specific aptamers to enhance detection multifactorial disease (MD) biomarkers. MDs, characterized by complex pathophysiology involving multiple genetic and environmental factors, present significant diagnostic challenges. Aptamers, which are short, single-stranded oligonucleotides high specificity affinity for target molecules, have emerged as promising tools biomarker detection. By utilizing response methodology (RSM) face-centered central composite design (FCCCD), this research systematically optimized bioconjugation process AuNPs different aptamer sequences, focusing parameters such AuNP size concentration. The developed protocol in demonstrated that aptamer-functionalized can be yield, efficiency, stability, coverage, making them suitable applications, particularly surface-enhanced Raman spectroscopy (SERS). findings provide a foundation development customizable nanoprobes adapted various biomarkers associated potentially improving early diagnosis therapeutic outcomes.
Язык: Английский
Процитировано
0
Journal of the American Heart Association, Год журнала: 2025, Номер unknown
Опубликована: Фев. 26, 2025
There existed bidirectional associations of cardiovascular disease (CVD) and type 2 diabetes (T2D) with cancer, partly attributed to their shared risk factors. We aimed explore the role health (CVH) in transitions between CVD, T2D, cancer. Based on UK Biobank, we used subcohorts: a disease-free cohort 277 997 individuals without T2D; survivor consisting 61 971 cases T2D at baseline. The CVH was assessed basis Life's Essential 8 score. conducted multistate model Cox proportional hazards cancer cohorts, respectively. High significantly associated lower transition from CVD (hazard ratio, 0.822 [95% CI, 0.693-0.975]). On other hand, increased related reduced risks progression (both P for trend<0.001), particularly high group. For per 10-point increase >10% cases, 16% 42% reduction incident among survivors, decreased This highlighted significance maintaining throughout life span primary prevention
Язык: Английский
Процитировано
0
International Journal of Radiation Biology, Год журнала: 2024, Номер 100(9), С. 1283 - 1296
Опубликована: Янв. 5, 2024
The radiation protection community has been particularly attentive to the risks of delayed effects on offspring from low dose or dose-rate exposures ionizing radiation. Despite this, current epidemiologic studies and scientific data are still insufficient provide necessary evidence for improving risk assessment guidelines. This literature review aims inform future multigenerational transgenerational effects. It primarily focuses animal involving
Язык: Английский
Процитировано
2
BMJ Open, Год журнала: 2024, Номер 14(4), С. e082414 - e082414
Опубликована: Апрель 1, 2024
Objectives To compare metabolic dysfunction-associated profiles between patients with diabetes who developed different obesity-related site-specific cancers and those remained free of cancer during follow-up. Design Retrospective cohort study. Setting Public general outpatient clinics in Hong Kong. Participants Patients without a history malignancy (n=391 921). Primary outcome measures The outcomes interest were diagnosis (colon rectum, liver, pancreas, bladder, kidney stomach) Cox proportional hazards regression was applied to assess the associations dysfunction other clinical factors each cancer. Results Each 0.1 increase waist-to-hip ratio associated an 11%–35% elevated risk colorectal, bladder liver cancers. 1% glycated haemoglobin linked 4%–9% higher pancreatic While low-density lipoprotein cholesterol triglycerides inversely cancers, high-density negatively pancreatic, gastric but positively Furthermore, cirrhosis 56% increased No significant association hypertension found. Conclusions Metabolic contribute differentially among diabetes. This study may provide evidence help identify prevention targets routine care.
Язык: Английский
Процитировано
2
Journal of Cardiovascular Development and Disease, Год журнала: 2024, Номер 11(8), С. 240 - 240
Опубликована: Авг. 5, 2024
To study the relationships of cardiovascular risk factors with cancer and mortality in a cohort middle-aged men followed-up for 61 years.
Язык: Английский
Процитировано
2
2022 9th International Conference on Computing for Sustainable Global Development (INDIACom), Год журнала: 2024, Номер unknown
Опубликована: Фев. 28, 2024
The paper presents a novel approach to multifactorial disorder risk assessment through the development and deployment of cross-platform application empowered by edge computing technology. Multifactorial disorders pose significant challenges public health, necessitating accurate tools for early detection prevention. Leveraging dataset sourced from Behavioral Risk Factor Surveillance System (BRFSS), selected 17 relevant features seven diseases analysis, converting them into binary classification variables. Our study focused on training models within the. NET Maui framework, achieving promising results with best-performing model exhibiting macro-accuracy 73.93%. Additionally, this developed tool framework that integrates enhance performance accessibility. incorporates feature selection engineering techniques, optimizing process. guides users self-check process, allowing input personal information obtain percentage assessments. Through innovative approach, our contributes efforts while addressing limitations existing methods. findings underscore potential technology in revolutionizing healthcare applications, paving way more effective accessible tools.
Язык: Английский
Процитировано
1