Obstructive
sleep
apnea
(OSA)
is
a
prevalent
sleep-related
breathing
disorder
that
results
in
multiple
bouts
of
intermittent
hypoxia.
OSA
has
many
neurologic
and
systemic
comorbidities
including
dysphagia,
or
disordered
swallow
discoordination
with
breathing.
However,
the
mechanism
which
chronic
hypoxia
(CIH)
causes
dysphagia
unknown.
Recently
we
showed
Postinspiratory
complex
(PiCo)
acts
as
an
interface
between
pattern
generator
(SPG)
inspiratory
rhythm
generator,
preBötzinger
Complex,
to
regulate
proper
swallow-breathing
coordination
(A.
D.
Huff
et
al.,
2023).
PiCo
characterized
by
interneurons
co-expressing
transporters
for
glutamate
(Vglut2)
acetylcholine
(ChAT).
Here
show
optogenetic
stimulation
ChATcre:Ai32,
Vglut2cre:Ai32,
ChATcre:Vglut2FlpO:ChR2
mice
exposed
CIH
does
not
alter
coordination,
but
unexpectedly
generation
motor
was
significantly
disturbed.
This
suggests,
glutamatergic-cholinergic
neurons
are
only
critical
gating
postinspiratory
activity,
also
play
important
roles
pattern.
Our
study
suggests
disruption,
seen
involves
central
nervous
mechanisms
interfering
laryngeal
activation.
These
findings
crucial
understanding
underlying
other
neurological
disorders.
Obstructive
sleep
apnea
(OSA)
is
a
prevalent
sleep-related
breathing
disorder
that
results
in
multiple
bouts
of
intermittent
hypoxia.
OSA
has
many
neurological
and
systemic
comorbidities,
including
dysphagia,
or
disordered
swallow,
discoordination
with
breathing.
However,
the
mechanism
which
chronic
hypoxia
(CIH)
causes
dysphagia
unknown.
Recently,
we
showed
postinspiratory
complex
(PiCo)
acts
as
an
interface
between
swallow
pattern
generator
(SPG)
inspiratory
rhythm
generator,
preBötzinger
complex,
to
regulate
proper
swallow-breathing
coordination
(Huff
et
al.,
2023).
PiCo
characterized
by
interneurons
co-expressing
transporters
for
glutamate
(Vglut2)
acetylcholine
(ChAT).
Here
show
optogenetic
stimulation
ChATcre:Ai32,
Vglut2cre:Ai32,
ChATcre:Vglut2FlpO:ChR2
mice
exposed
CIH
does
not
alter
coordination,
but
unexpectedly
disrupts
behavior
via
triggering
variable
motor
patterns.
This
suggests
glutamatergic-cholinergic
neurons
are
only
critical
regulation
also
play
important
role
modulation
patterning.
Our
study
disruption,
seen
OSA,
involves
central
nervous
mechanisms
interfering
patterning
laryngeal
activation.
These
findings
crucial
understanding
underlying
both
other
disorders.
Journal of Clinical Sleep Medicine,
Год журнала:
2023,
Номер
20(4), С. 515 - 520
Опубликована: Дек. 6, 2023
Cancer
is
one
of
the
main
causes
death
in
world,
and
sleep
disorders
are
a
serious
public
health
problem,
especially
large
cities;
these,
insomnia
obstructive
apnea
(OSA)
most
common.
In
last
decade,
studies
have
pointed
to
possible
association
between
cancer.
The
aim
this
study
evaluate
whether
there
any
In
recent
years,
the
relationship
between
obstructive
sleep
apnea
(OSA)
and
cancer
has
emerged
as
a
new
field
of
investigation.
Animal
studies
on
OSA
have
been
performed
more
than
10
years
ago,
while
clinical
are
recent.
The
current
state
knowledge
is
steadily
growing,
but
several
topics
still
represent
areas
uncertainty,
including
mechanisms
specific
for
each
type,
epidemiological
aspects
OSA-cancer
association.
To
date,
melanoma
type
better
characterized
from
both
biological
points
view.
This
updated
narrative
review
summarizes
results
experimental
biology
cancer,
incidence
in
patients,
potential
negative
effects
patients
with
head
neck
lung
cancer.
few
positive
airway
pressure
treatment
aggressiveness
or
mortality
critically
examined,
particles
volatile
organic
compounds
released
by
PAP
devices.
Finally,
future
perspectives
briefly
outlined.
conclusion,
complex,
insufficiently
studied.
While
data
indicate
plausibility
intermittent
hypoxia
fragmentation
risk
factors
too
to
draw
conclusions,
question
possible
protective
effect
remains
unanswered.
Obstructive
sleep
apnea
(OSA)
is
a
prevalent
sleep-related
breathing
disorder
that
results
in
multiple
bouts
of
intermittent
hypoxia.
OSA
has
many
neurologic
and
systemic
comorbidities
including
dysphagia,
or
disordered
swallow,
discoordination
with
breathing.
However,
the
mechanism
which
chronic
hypoxia
(CIH)
causes
dysphagia
unknown.
Recently
we
showed
Postinspiratory
complex
(PiCo)
acts
as
an
interface
between
swallow
pattern
generator
(SPG)
inspiratory
rhythm
generator,
preBötzinger
Complex,
to
regulate
proper
swallow-breathing
coordination
(Huff
et
al.,
2023).
PiCo
characterized
by
interneurons
co-expressing
transporters
for
glutamate
(Vglut2)
acetylcholine
(ChAT).
Here
show
optogenetic
stimulation
ChATcre:Ai32,
Vglut2cre:Ai32,
ChATcre:Vglut2FlpO:ChR2
mice
exposed
CIH
does
not
alter
coordination,
but
unexpectedly
triggers
variable
motor
patterns.
This
suggests,
glutamatergic-cholinergic
neurons
are
only
critical
regulation
also
play
important
role
modulation
patterning.
Our
study
suggests
disruption,
seen
OSA,
involves
central
nervous
mechanisms
interfering
patterning
laryngeal
activation.
These
findings
crucial
understanding
underlying
other
neurological
disorders.
Obstructive
sleep
apnea
(OSA)
is
a
prevalent
sleep-related
breathing
disorder
that
results
in
multiple
bouts
of
intermittent
hypoxia.
OSA
has
many
neurological
and
systemic
comorbidities,
including
dysphagia,
or
disordered
swallow,
discoordination
with
breathing.
However,
the
mechanism
which
chronic
hypoxia
(CIH)
causes
dysphagia
unknown.
Recently,
we
showed
postinspiratory
complex
(PiCo)
acts
as
an
interface
between
swallow
pattern
generator
(SPG)
inspiratory
rhythm
generator,
preBötzinger
complex,
to
regulate
proper
swallow-breathing
coordination
(Huff
et
al.,
2023).
PiCo
characterized
by
interneurons
co-expressing
transporters
for
glutamate
(Vglut2)
acetylcholine
(ChAT).
Here
show
optogenetic
stimulation
ChATcre:Ai32,
Vglut2cre:Ai32,
ChATcre:Vglut2FlpO:ChR2
mice
exposed
CIH
does
not
alter
coordination,
but
unexpectedly
disrupts
behavior
via
triggering
variable
motor
patterns.
This
suggests
glutamatergic–cholinergic
neurons
are
only
critical
regulation
also
play
important
role
modulation
patterning.
Our
study
disruption,
seen
OSA,
involves
central
nervous
mechanisms
interfering
patterning
laryngeal
activation.
These
findings
crucial
understanding
underlying
both
other
disorders.
European Respiratory Journal,
Год журнала:
2024,
Номер
64(5), С. 2401591 - 2401591
Опубликована: Ноя. 1, 2024
Extract
There
is
an
expanding
literature
on
the
association
between
obstructive
sleep
apnoea
(OSA)
and
cancer
risk
[1,
2].
Evidence
growing
from
population-
clinic-based
cohort
studies
that
severity
of
OSA
sleep-related
hypoxaemia
may
adversely
affect
both
overall
incidence
certain
cancers
[3–7].
These
clinical
findings
are
supported
by
identification
intermediate
mechanisms
which
intermittent
hypoxia
fragmentation,
hallmark
features
OSA,
might
promote
oncogenesis,
tumour
growth
metastasis
[8].
Although
have
shown
a
relationship
cancer,
few
evaluated
whether
development
or
progression
in
patients
with
modified
continuous
positive
airway
pressure
(CPAP)
therapy
(the
primary
treatment
for
OSA)
