Journal of drug targeting,
Год журнала:
2024,
Номер
unknown, С. 1 - 23
Опубликована: Ноя. 18, 2024
Glioblastoma
multiforme
(GBM),
the
most
aggressive
form
of
brain
cancer,
poses
substantial
challenges
to
effective
treatment
due
its
complex
and
infiltrative
nature,
making
it
difficult
manage.
Photodynamic
therapy
(PDT)
sonodynamic
(SDT),
have
emerged
as
promising
individual
options
against
GBM
their
least-invasive
approach.
However,
both
PDT
SDT
drawbacks
that
require
careful
consideration.
A
combination
using
light
sound
waves
has
gained
attention,
offering
new
avenues
overcome
from
therapies.
Sono-photodynamic
(SPDT)
been
used
various
tumors.
Researchers
are
considering
SPDT
a
favorable
alternative
conventional
therapies
for
GBM.
offers
complementary
mechanisms
action,
including
production
ROS,
disruption
cellular
structures,
induction
apoptosis,
leading
enhanced
tumor
cell
death.
This
review
gives
an
insight
about
PDT/SDT
limitations
in
need
therapy.
We
try
unveil
process
explore
mechanism
behind
improved
SPDT-meditated
death
cells
by
focusing
on
ROS-mediated
response
occurring
result
discussing
current
modifications
existing
sensitizers
optimal
use
Analytical Chemistry,
Год журнала:
2024,
Номер
96(6), С. 2406 - 2414
Опубликована: Фев. 3, 2024
Glioblastoma
multiforme
(GBM)
is
a
highly
aggressive
primary
brain
tumor
associated
with
limited
treatment
options
and
high
drug
resistance,
presenting
significant
challenges
in
the
pursuit
of
effective
strategies.
Epigenetic
modifications
have
emerged
as
promising
diagnostic
biomarkers
therapeutic
targets
for
GBM.
For
instance,
histone
deacetylase
6
(HDAC6)
has
been
identified
potential
pharmacological
target
Furthermore,
overexpression
monoamine
oxidase
A
(MAO
A)
glioma
linked
to
progression,
making
it
an
attractive
therapy.
In
this
study,
we
successfully
engineered
HDAC-MB,
activatable
multifunctional
small-molecule
probe
goal
efficiently
detecting
killing
cells.
HDAC-MB
can
be
selectively
activated
by
HDAC6,
leading
"turn
on"
near-infrared
fluorescence
inhibition
MAO
A,
along
potent
photodynamic
therapy
(PDT)
effects.
Consequently,
not
only
enables
imaging
HDAC6
live
cells
but
also
exhibits
synergistic
effect
PDT,
effectively
inhibiting
invasion
inducing
cellular
apoptosis.
The
distinctive
combination
features
displayed
positions
versatile
tool
accurate
diagnosis
This
opens
up
opportunities
enhance
outcomes
explore
future
applications
theranostics.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(11), С. 6118 - 6118
Опубликована: Июнь 1, 2024
Glioblastoma
is
a
highly
aggressive
neoplasm
and
the
most
common
primary
malignant
brain
tumor.
Endothelial
tissue
plays
critical
role
in
glioblastoma
growth
progression,
facilitating
angiogenesis,
cellular
communication,
tumorigenesis.
In
this
review,
we
present
an
up-to-date
comprehensive
summary
of
endothelial
cells
glioblastomas,
along
with
overview
recent
developments
therapies
tumor
marker
identification.
Glioblastoma
(GBM)
is
a
highly
invasive,
aggressive
brain
cancer
that
carries
median
survival
of
15
months
and
resistant
to
standard
therapeutics.
Recent
studies
have
demonstrated
intratumoral
heterogeneity
plays
critical
role
in
promoting
resistance
by
mediating
tumor
adaptation
through
microenvironmental
cues.
GBM
can
be
separated
into
two
distinct
regions—a
core
rim,
which
are
thought
drive
specific
aspects
evolution.
These
differences
progression
regulated
the
diverse
biomolecular
biophysical
signals
these
regions,
but
acellular
characteristics
remain
poorly
described.
This
study
investigates
mechanical
ultrastructural
extracellular
matrix
(ECM)
patient-matched
rim
tissues.
Seven
samples
one
non-neoplastic
control
were
analyzed
using
atomic
force
microscopy,
scanning
electron
immunofluorescence
imaging
quantify
mechanical,
ultrastructural,
ECM
composition
changes.
The
results
reveal
significant
parameters
between
core,
stiffer,
denser,
rich
proteins
hyaluronic
acid
tenascin-C
when
compared
alterations
intimately
related
prognostic
effect
with
stiff,
dense
tissue
correlating
longer
progression-free
survival.
findings
new
insights
spatial
microenvironment
identify
set
may
correlate
patient
prognosis.
In
long
term,
aid
development
strategies
combat
therapeutic
resistance.
Journal of drug targeting,
Год журнала:
2024,
Номер
unknown, С. 1 - 23
Опубликована: Ноя. 18, 2024
Glioblastoma
multiforme
(GBM),
the
most
aggressive
form
of
brain
cancer,
poses
substantial
challenges
to
effective
treatment
due
its
complex
and
infiltrative
nature,
making
it
difficult
manage.
Photodynamic
therapy
(PDT)
sonodynamic
(SDT),
have
emerged
as
promising
individual
options
against
GBM
their
least-invasive
approach.
However,
both
PDT
SDT
drawbacks
that
require
careful
consideration.
A
combination
using
light
sound
waves
has
gained
attention,
offering
new
avenues
overcome
from
therapies.
Sono-photodynamic
(SPDT)
been
used
various
tumors.
Researchers
are
considering
SPDT
a
favorable
alternative
conventional
therapies
for
GBM.
offers
complementary
mechanisms
action,
including
production
ROS,
disruption
cellular
structures,
induction
apoptosis,
leading
enhanced
tumor
cell
death.
This
review
gives
an
insight
about
PDT/SDT
limitations
in
need
therapy.
We
try
unveil
process
explore
mechanism
behind
improved
SPDT-meditated
death
cells
by
focusing
on
ROS-mediated
response
occurring
result
discussing
current
modifications
existing
sensitizers
optimal
use
