Neuroprotective Effects of Curcumin in Neurodegenerative Diseases

Foods, Год журнала: 2024, Номер 13(11), С. 1774 - 1774

Опубликована: Июнь 5, 2024

Curcumin, a hydrophobic polyphenol extracted from the rhizome of Curcuma longa, is now considered candidate drug for treatment neurological diseases, including Parkinson’s Disease (PD), Alzheimer’s (AD), Huntington’s (HD), Multiple Sclerosis (MS), Amyotrophic Lateral (ALS), and prion disease, due to its potent anti-inflammatory, antioxidant potential, anticancerous, immunomodulatory, neuroprotective, antiproliferative, antibacterial activities. Traditionally, curcumin has been used medicinal dietary purposes in Asia, India, China. However, low water solubility, poor stability blood, high rate metabolism, limited bioavailability, little capability cross blood–brain barrier (BBB) have clinical application curcumin, despite important pharmacological activities this drug. A variety nanocarriers, liposomes, micelles, dendrimers, cubosome nanoparticles, polymer solid lipid nanoparticles developed with great success effectively deliver active brain cells. Functionalization on surface brain-specific ligands makes them target-specific, which should significantly improve bioavailability reduce harmful effects. The aim review summarize studies and/or containing most common neurodegenerative highlighting neuroprotective potential nutraceutical.

Язык: Английский

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Phytochemicals Involved in Mitigating Silent Toxicity Induced by Heavy Metals

Foods, Год журнала: 2024, Номер 13(7), С. 978 - 978

Опубликована: Март 22, 2024

Heavy metals (HMs) are natural elements present in the Earth’s crust, characterised by a high atomic mass and density more than five times higher water. Despite their origin from sources, extensive usage processing of raw materials presence as silent poisons our daily products diets have drastically altered biochemical balance, making them threat to environment human health. Particularly, food chain polluted with toxic represents crucial route exposure. Therefore, impact HMs on health has become matter concern because severe chronic effects induced excessive levels body. Chelation therapy is an approved valid treatment for HM poisoning; however, despite efficacy demonstrated chelating agents, various dramatic side may occur. Numerous data demonstrate that dietary components phytoantioxidants play significant role preventing or reducing damage HMs. This review summarises phytochemicals, plant herbal extracts probiotics promoting mitigating different

Язык: Английский

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Dioscin inhibits non-small cell lung cancer cells and activates apoptosis by downregulation of Survivin

Journal of Cancer, Год журнала: 2024, Номер 15(5), С. 1366 - 1377

Опубликована: Янв. 1, 2024

Human malignancies exhibit elevated levels of survivin, and have been linked to poor prognosis.Targeting survivin expression is a promising therapeutic strategy against cancer cells.Natural compounds become hot topic in research due their non-toxic, non-invasive, efficient treatment multiple diseases.In this current investigation, it was discovered that Dioscin, as natural compound, exerted profound antitumor activity NSCLC cell lines, inhibiting viability promoting apoptosis.Further mechanistic studies showed Dioscin promoted ubiquitination-mediated degradation via strengthening the interaction between E3 ubiquitin ligase Fbxl7.Furthermore, exhibited strong tumor suppressive effect xenograft models, led notable decrease volume weight.Based on our findings, expected be potential agent for non-small lung treatment.

Язык: Английский

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Phytocompounds and Nanoformulations for Anticancer Therapy: A Review

Molecules, Год журнала: 2024, Номер 29(16), С. 3784 - 3784

Опубликована: Авг. 9, 2024

Cancer is a complex disease that affects millions of people and remains major public health problem worldwide. Conventional cancer treatments, including surgery, chemotherapy, immunotherapy, radiotherapy, have limited achievements multiple drawbacks, among which are healthy tissue damage multidrug-resistant phenotype onset. Increasing evidence shows many plants’ natural products, as well their bioactive compounds, promising anticancer activity exhibit minimal toxicity compared to conventional drugs. However, widespread use in therapy severely restricted by limitations terms water solubility, absorption, lack stability, bioavailability, selective targeting. The nanoformulations for product transportation delivery could be helpful overcoming these limitations, thus enhancing therapeutic efficacy providing the basis improved treatment strategies. present review aimed at an update on some phytocompounds (curcumin, resveratrol, quercetin, cannabinoids, others) main showing antitumor activities, both vitro vivo, against such different human types breast colorectal cancer, lymphomas, malignant melanoma, glioblastoma multiforme, osteosarcoma. intracellular pathways underlying phytocompound advantages nanoformulation employment also examined. Finally, this critically analyzes research gaps causing success phytocompounds’ nanoformulations’ clinical translation.

Язык: Английский

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Computational identification of potential natural terpenoid inhibitors of MDM2 for breast cancer therapy: molecular docking, molecular dynamics simulation, and ADMET analysis

Frontiers in Chemistry, Год журнала: 2025, Номер 13

Опубликована: Апрель 16, 2025

Background Breast cancer (BC) remains a leading cause of cancer-related mortality in women. The oncoprotein MDM2 negatively regulates the tumor suppressor p53, and its overexpression BC promotes progression resistance to therapy. Targeting MDM2-p53 interaction represents promising therapeutic approach. However, many existing inhibitors suffer from poor pharmacokinetics off-target toxicity, necessitating discovery novel, more selective alternatives. This study aims identify natural terpenoid compounds with potent inhibitory potential through computational approaches. Methods A library 398 terpenoids was sourced NPACT database filtered based on Lipinski’s Rule Five. two-stage docking strategy applied: 1) rigid protein-flexible ligand screen for high-affinity binders, followed by 2) ensemble using multiple conformations derived molecular dynamics (MD) simulations. top candidates were further evaluated their pharmacokinetic toxicity profiles ADMET analysis. Finally, 150 ns MD simulations binding free energy (MM-PBSA) calculations performed assess stability strength protein-ligand interactions. Results Three compounds, olean-12-en-3-beta-ol, cabralealactone, 27-deoxyactein demonstrated strong affinities toward studies. analysis confirmed favorable properties. Further indicated that these formed highly stable complexes MDM2. Notably, exhibited lowest (−154.514 kJ/mol), outperforming reference inhibitor Nutlin-3a (−133.531 suggesting superior strength. Conclusion Our findings highlight as affinity, stability, profile. provides foundation experimental validation, supporting terpenoid-based

Язык: Английский

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Anti-inflammatory, antithrombotic and anti-oxidant bioactives of beer and brewery by-products, as ingredients of bio-functional foods, nutraceuticals, cosmetics, cosmeceuticals and pharmaceuticals with health promoting properties

AIMS Agriculture and Food, Год журнала: 2024, Номер 9(2), С. 568 - 606

Опубликована: Янв. 1, 2024

<abstract> <p>Fermented alcoholic beverages and their by-products, including beer breweries' bio-wastes like spent yeasts, grain, hops, contain a plethora of natural bioactive compounds that have recently gained attention for valorization as functional ingredients in several novel foods nutraceuticals, well drugs cosmetics applications. Within this article, the bio-functional fermented product by-products with anti-inflammatory, antithrombotic, anti-oxidant bioactivities are thoroughly reviewed. The important roles yeasts involved such bioactives to be present brewery also outlined. health promoting benefits moderate consumption resulting from these bioactives, part balanced diet, against inflammation-related chronic disorders is discussed, along detrimental effects abuse potential alternative non-alcoholic beers. mechanisms action synergism anti-thrombotic, antioxidant properties presented. Current research future perspectives on valorizing grain hops health-promoting foods, supplements, nutraceuticals cosmetics, cosmeceuticals, pharmaceuticals evaluated, while limitations use discussed.</p> </abstract>

Язык: Английский

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New insights of LncRNAs fingerprints in breast cancer progression: Tumorigenesis, drug resistance, and therapeutic opportunities

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 287, С. 138589 - 138589

Опубликована: Дек. 9, 2024

Breast cancer (BC) is one of the common female cancers and it characterized by considerable problems regarding its development therapy. Long non-coding RNAs (lncRNAs) have been identified as significant modulators in BC development, especially, tumorigenicity chemoresistance. We therefore endeavor to present an up-to-date understanding lncRNAs their impact on progression treatment, concerning molecular processes, treatment options, use a therapeutic opportunity. LncRNAs are novel regulators genes that cause resistance directly functioning both coding patients, but little known about mechanisms actions. Thus, additional study required deeper modes action possible roles disease. This aims investigate functions BC, with particular attention role tumorigenesis, drug mechanisms, targets. will help identify targets improve effectiveness treatment.

Язык: Английский

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Potential anti-cancer activity of Moringa oleifera derived bio-active compounds targeting hypoxia-inducible factor-1 alpha in breast cancer

Journal of Complementary and Integrative Medicine, Год журнала: 2023, Номер 21(3), С. 282 - 294

Опубликована: Сен. 15, 2023

Breast cancer (BC) will become a highly detected malignancy in females worldwide 2023, with over 2 million new cases. Studies have established the role of hypoxia-inducible factor-1α (HIF1α), transcription factor that controls cellular response to hypoxic stress, and is essential for BC spread. HIF-1 implicated nearly every critical stage metastatic progression, including invasion, EMT, intravasation, extravasation, angiogenesis, formation niches. overexpression has been associated poor prognosis increased mortality patients. This accomplished by controlling expression target genes involved cell survival, metabolism, treatment resistance. indicated inhibiting an anti-cancer effect on its own HIF-1-mediated signaling improves efficacy therapy. Approximately 74 % recognized drugs are sourced from plant species. characteristics phytochemicals derived Moringa oleifera (MO), also known as 'Tree Life', revealed high therapeutic potential BC. In this review, we highlighted various mechanisms through which bioactive compounds present MO may modulate HIF regulatory genes/pathways, prove their treating preventing

Язык: Английский

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The cytotoxic potential of sinapic acid on luminal A breast cancer; a computational and experimental pharmacology approach

Journal of Biomolecular Structure and Dynamics, Год журнала: 2023, Номер 42(23), С. 13216 - 13231

Опубликована: Окт. 30, 2023

Breast cancer is a highly concerning and prevalent disease that impacts significant proportion of women worldwide, whose repeated exposure to therapies leads resistance for drugs; making it alarming identify novel chemotherapeutic agents. Sinapic acid phenolic occurs naturally known exhibit cytotoxic action in variety cell types. In the present study, we utilized cytotoxicity assays assess potential sinapic on various breast subtypes. addition, assessed migration rate, apoptosis, cycle phases. Moreover, multiple system biology tools predict targets, molecular docking was performed hub targets followed by dynamic (MD) simulations. Cytotoxicity assay lines MCF7, T47D, MDA-MB-468, SKBR3 at different time exposures 24, 48, 96 h. Our results revealed be potent MCF7 T47D lines. The analysis apoptotic cause death apoptosis majorly G0/G1 phase. Computational KIF18B VKORC1 possess highest binding affinity −6.5 −7.5 kcal/mol; displayed stable trajectories MD run. luminal A may due modulation with major However, mechanism has been proposed via silico tools, which need further validation using wet lab protocols.

Язык: Английский

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Exploring the potential of tocopherols: mechanisms of action and perspectives in the prevention and treatment of breast cancer

Medical Oncology, Год журнала: 2024, Номер 41(9)

Опубликована: Июль 26, 2024

Язык: Английский

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