The Cellular Stress and Cutaneous Manifestations in Renal Cell Carcinomas—A Narrative Review DOI Open Access
Corina Daniela Ene, Ilinca Nicolae, Mircea Tampa

и другие.

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(13), С. 3640 - 3640

Опубликована: Июнь 21, 2024

The carcinomas originating from the renal cortex are most aggressive malignancies, with a high tendency for metastasis. Understanding incidence of cutaneous manifestations caused by is challenge. In first part, this article summarizes series factors that promote oncogenesis, invasiveness, and ability cell carcinoma (RCC) to develop secondary manifestations. It postulated cellular stress response one leading causes developing dermatological events induced cancers located at distant sites. Furthermore, paper provides an overview complications associated cancer, categorized as malignant (metastases, synchronous or metachronous malignancies cancer), non-malignant indirect treatment consequences. data presented in suggest recognizing certain disorders could assist physician early identification neoplasms lead better prognosis.

Язык: Английский

Role of SLC7A11/xCT in Ovarian Cancer DOI Open Access
Sonia Fantone, Federica Piani, Fabiola Olivieri

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(1), С. 587 - 587

Опубликована: Янв. 2, 2024

Ovarian cancer is one of the most dangerous gynecologic cancers worldwide and has a high fatality rate due to diagnosis at an advanced stage disease as well recurrence occurrence chemotherapy resistance. In fact, chemoresistance weakens therapeutic effects, worsening outcome this pathology. Solute Carrier Family 7 Member 11 (SLC7A11, also known xCT) functional subunit Xc− system, anionic L-cystine/L-glutamate antiporter expressed on cell surface. SLC7A11 expression significantly upregulated in several types which it can inhibit ferroptosis favor proliferation, invasion chemoresistance. increased ovarian tissues, suggesting possible role protein target. review, we provide overview current literature regarding new insights modulation evaluate potential

Язык: Английский

Процитировано

55
The molecular code of kidney cancer: A path of discovery for gene mutation and precision therapy DOI Creative Commons
Deqian Xie,

Guandu Li,

Zhonghua Zheng

и другие.

Molecular Aspects of Medicine, Год журнала: 2025, Номер 101, С. 101335 - 101335

Опубликована: Янв. 1, 2025

Renal cell carcinoma (RCC) is a malignant tumor with highly heterogeneous and complex molecular mechanisms. Through systematic analysis of TCGA, COSMIC other databases, 24 mutated genes closely related to RCC were screened, including VHL, PBRM1, BAP1 SETD2, which play key roles in signaling pathway transduction, chromatin remodeling DNA repair. The PI3K/AKT/mTOR particularly important the pathogenesis RCC. Mutations such as PIK3CA, MTOR PTEN are associated metabolic abnormalities proliferation. Clinically, mTOR inhibitors VEGF-targeted drugs have shown significant efficacy personalized therapy. Abnormal regulation reprogramming, especially glycolysis glutamine pathways, provides cells continuous energy supply survival advantages, GLS1 promising results preclinical studies. This paper also explores potential immune checkpoint combination targeted drugs, well application nanotechnology drug delivery In addition, unique mechanisms revealed individualized therapeutic strategies explored for specific subtypes TFE3, TFEB rearrangement type SDHB mutant type. review summarizes common gene mutations their mechanisms, emphasizes diagnosis, treatment prognosis, looks forward prospects multi-pathway therapy, immunotherapy treatment, providing theoretical support clinical guidance new development.

Язык: Английский

Процитировано

2
Cuproptosis, the novel type of oxidation-induced cell death in thoracic cancers: can it enhance the success of immunotherapy? DOI Creative Commons

Ruiwen Zhao,

Olga Sukocheva, Edmund C. M. Tse

и другие.

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Июль 27, 2024

Abstract Copper is an important metal micronutrient, required for the balanced growth and normal physiological functions of human organism. Copper-related toxicity dysbalanced metabolism were associated with disruption intracellular respiration development various diseases, including cancer. Notably, copper-induced cell death was defined as cuproptosis which also observed in malignant cells, representing attractive anti-cancer instrument. Excess copper leads to aggregation lipoylation proteins toxic stress, ultimately resulting activation death. Differential expression cuproptosis-related genes detected tissues. Cuproptosis-related linked regulation oxidative immune responses, composition tumor microenvironment. Activation increased redox-metabolism-regulating genes, such ferredoxin 1 (FDX1), lipoic acid synthetase (LIAS), lipoyltransferase (LIPT1), dihydrolipoamide dehydrogenase (DLD), drolipoamide S-acetyltransferase (DLAT), pyruvate E1 subunit alpha (PDHA1), beta (PDHB)). Accordingly, copper-activated network suggested target cancer therapy. Mechanisms different cancers microenvironment are discussed this study. The analysis current findings indicates that therapeutic signaling, targets may provide effective tool improvement immunotherapy regimens. Graphical

Язык: Английский

Процитировано

7
Differential expression analysis identifies a prognostically significant extracellular matrix–enriched gene signature in hyaluronan-positive clear cell renal cell carcinoma DOI Creative Commons
Otto Jokelainen, Teemu Rintala, Vittorio Fortino

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Май 9, 2024

Abstract Hyaluronan (HA) accumulation in clear cell renal carcinoma (ccRCC) is associated with poor prognosis; however, its biology and role tumorigenesis are unknown. RNA sequencing of 48 HA-positive HA-negative formalin-fixed paraffin-embedded (FFPE) samples was performed to identify differentially expressed genes (DEG). The DEGs were subjected pathway gene enrichment analyses. Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma (TCGA-KIRC) data used for the cluster analysis. In total, 129 identified. tumors exhibited enhanced expression related extracellular matrix (ECM) organization ECM receptor interaction pathways. Gene set analysis showed that epithelial–mesenchymal transition-associated highly enriched phenotype. A protein–protein network constructed, 17 hub discovered. Heatmap TCGA-KIRC identified two prognostic clusters corresponding phenotypes. These verify levels conduct survival genes, 11 which linked prognosis. findings enhance our understanding hyaluronan ccRCC.

Язык: Английский

Процитировано

4
Nrf2 Signaling in Renal Cell Carcinoma: A Potential Candidate for the Development of Novel Therapeutic Strategies DOI Open Access
Valentina Schiavoni, Monica Emanuelli, Giulio Milanese

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(24), С. 13239 - 13239

Опубликована: Дек. 10, 2024

Renal cell carcinoma (RCC) is the most common type of kidney cancer arising from renal tubular epithelial cells and characterized by a high aggressive behavior invasiveness that lead to poor prognosis mortality rate. Diagnosis RCC generally incidental occurs when stage advanced disease already metastatic. The management further complicated an intrinsic resistance this malignancy chemotherapy radiotherapy, which aggravates prognosis. For these reasons, there intense research focused on identifying novel biomarkers may be useful for better prognostic assessment, as well molecular markers could utilized targeted therapy. Nuclear factor erythroid 2-related 2 (Nrf2) transcriptional has been identified key modulator oxidative stress response, its overexpression considered negative feature in several types cancers including RCC, since it involved various cancer-promoting functions such proliferation, anabolic metabolism chemotherapy. Given role Nrf2 promoting tumor progression, enzyme promising biomarker more accurate prediction course can also represent valuable therapeutic target. In review, we provide comprehensive literature analysis studies have explored underlining possible implications

Язык: Английский

Процитировано

4
The HOX Gene Family’s Role as Prognostic and Diagnostic Biomarkers in Hematological and Solid Tumors DOI Open Access
Kaci Kopec,

Danielle Quaranto,

Nicole R. DeSouza

и другие.

Cancers, Год журнала: 2025, Номер 17(2), С. 262 - 262

Опубликована: Янв. 15, 2025

The HOX gene family encodes for regulatory transcription factors that play a crucial role in embryogenesis and differentiation of adult cells. This highly conserved genes consists thirty-nine humans are located four clusters, A–D, on different chromosomes. While early studies the have been focused embryonic development its related disorders, research has shifted to examine aberrant expression subsequent implication cancer prediction progression. Due their encoding master factors, abnormal shown affect all stages tumorigenesis metastasis. review highlights novel family’s clinical relevance as both prognostic diagnostic biomarkers hematological solid tumors.

Язык: Английский

Процитировано

0
Role of Natural Compounds as Anti-Cancer Agents DOI
Giovanni Tossetta

Anti-Cancer Agents in Medicinal Chemistry, Год журнала: 2025, Номер 25(5), С. 293 - 294

Опубликована: Янв. 28, 2025

Язык: Английский

Процитировано

0
Cuproptosis Regulation by Long Noncoding RNAs: Mechanistic Insights and Clinical Implications in Cancer DOI

Nahla E. El‐Ashmawy,

Eman G. Khedr, Mariam A. Abo-Saif

и другие.

Archives of Biochemistry and Biophysics, Год журнала: 2025, Номер unknown, С. 110324 - 110324

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
The Role and Mechanisms of Aurora Kinases in Kidney Diseases DOI Creative Commons
Mei‐Ying Chang, Qiuyi Li,

Zhonghong Shi

и другие.

Clinical Pharmacology & Therapeutics, Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

Aurora kinases are a family of serine/threonine that includes kinase A, B, and C. These play crucial roles in mitotic spindle formation cell proliferation. Over the past several decades, extensive research has elucidated multifaceted cancer development progression. Recent studies have also highlighted significant involvement various kidney diseases, such as renal carcinoma, diabetic nephropathy, chronic disease, polycystic disease. The mechanisms by which contribute to diseases complex influenced both specific pathological conditions environmental factors. In this review, we comprehensively summarize role through operate discuss efficacy application existing inhibitors targeting these managing disorders animal models.

Язык: Английский

Процитировано

0
Differentiating between renal medullary and clear cell renal carcinoma with a machine learning radiomics approach DOI Creative Commons
Rahim Jiwani, Koustav Pal, Iwan Paolucci

и другие.

The Oncologist, Год журнала: 2025, Номер 30(2)

Опубликована: Фев. 1, 2025

Abstract Background The objective of this study was to develop and validate a radiomics-based machine learning (ML) model differentiate between renal medullary carcinoma (RMC) clear cell (ccRCC). Methods This retrospective Institutional Review Board -approved analyzed CT images clinical data from patients with RMC (n = 87) ccRCC 93). Patients without contrast-enhanced scans obtained before nephrectomy were excluded. A standard volumetric software package (MIM 7.1.4, MIM Software Inc.) used for contouring, after which 949 radiomics features extracted PyRadiomics 3.1.0. Radiomics analysis then performed RadAR differential analysis. ML extreme gradient boosting (XGBoost 2.0.3) ccRCC. Three separate models created RMC. These based on demographics, radiomics, incorporating hemoglobin electrophoresis sickle trait, respectively. Results Performance metrics the 3 developed as follows: demographic factors only (AUC 0.777), calibrated 0.915), trait incorporated 1.0). top 4 ranked radiomic analysis, by their importance, run entropy (preprocessing filter original, AUC 0.67), dependence wavelet, zone 0.66). Conclusion effectively differentiates tool can facilitate radiologist’s ability suspicion decrease misdiagnosis rate

Язык: Английский

Процитировано

0