Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Год журнала:
2024,
Номер
unknown, С. 29 - 52
Опубликована: Дек. 17, 2024
Tumor
formation
and
progression
are
caused
by
neoplastic
cells,
which
take
advantage
of
interfere
with
cellular
processes
that
control
growth,
survival,
division.
New
research
emphasizes
the
critical
role
tumor
microenvironment
(TME)
in
cancer
initiation
metastasis,
even
though
genetic
epigenetic
changes
well-known
malignant
transformation.
The
influences
metagenesis,
angiogenesis,
immune
tolerance,
helps
cells
proliferate
rapidly.
It
also
plays
a
origin,
progression,
invasion
cancer.
With
variety
roles,
including
matrix
deposition
remodeling,
extensive
reciprocal
signaling
connections
crosstalk
invading
leukocytes,
cancer-associated
fibroblasts
(CAFs)
an
essential
part
microenvironment.
This
chapter
reveals
origins
CAFs
heterogeneity
CAF
function,
wherein
it
is
preferable
to
preserve
some
antitumorigenic
properties.
ABSTRACT
Cancer
is
a
complex
and
heterogeneous
disease
characterised
by
uncontrolled
cell
growth
proliferation.
One
hallmark
of
cancer
cells
their
ability
to
undergo
metabolic
reprogramming,
which
allows
them
sustain
rapid
survival.
This
reprogramming
creates
an
immunosuppressive
microenvironment
that
facilitates
tumour
progression
evasion
the
immune
system.
In
this
article,
we
review
mechanisms
underlying
in
discuss
how
these
alterations
contribute
establishment
microenvironment.
We
also
explore
potential
therapeutic
strategies
targeting
vulnerabilities
enhance
immune‐mediated
anti‐tumour
responses.
Trial
Registration
ClinicalTrials.gov
identifier:
NCT02044861,
NCT03163667,
NCT04265534,
NCT02071927,
NCT02903914,
NCT03314935,
NCT03361228,
NCT03048500,
NCT03311308,
NCT03800602,
NCT04414540,
NCT02771626,
NCT03994744,
NCT03229278,
NCT04899921
The
following
narrative
review
embarks
on
a
comprehensive
exploration
of
the
pivotal
role
played
by
gut
microbiome
within
Diet-Microbiota-Immunity
(DMI)
tripartite,
aiming
to
enhance
anti-cancer
immunotherapy
efficacy.
While
revolutionizing
cancer
treatment,
resistance
and
immune-related
adverse
events
(irAEs)
remain
challenges.
tumor
microenvironment
(TME),
shaped
cells,
influences
resistance.
microbiome,
influenced
genetics,
environment,
diet,
interventions,
emerges
as
critical
player
in
TME
reshaping,
thereby
modulating
immune
responses
treatment
outcomes.
Dietary
patterns
like
Mediterranean
caloric
restriction
modifications,
specific
nutritional
components
show
promise
influencing
for
better
Antibiotics,
disrupting
microbiota
diversity,
may
compromise
efficacy.
This
emphasizes
need
tailored
strategies
manipulate
microbial
communities,
regulation,
improve
accessibility
while
minimizing
side
effects.
Ongoing
studies
investigate
impact
dietary
interventions
immunotherapy,
pointing
towards
promising
developments
personalized
care.
synthesizes
existing
knowledge
charts
course
future
investigations,
presenting
holistic
perspective
dynamic
interplay
between
DMI
tripartite.
Metabolites,
Год журнала:
2024,
Номер
14(1), С. 51 - 51
Опубликована: Янв. 13, 2024
The
major
liver
cancer
subtype
is
hepatocellular
carcinoma
(HCC).
Studies
have
indicated
that
a
better
prognosis
related
to
the
presence
of
tumor-infiltrating
lymphocytes
(TILs)
in
HCC.
However,
molecular
pathways
drive
immune
cell
variation
tumor
microenvironment
(TME)
remain
poorly
understood.
Glycosylation
(GLY)-related
genes
vital
function
pathogenesis
numerous
tumors,
including
This
study
aimed
develop
GLY/TME
classifier
based
on
glycosylation-related
gene
scores
and
provide
novel
prognostic
model
improve
prediction
clinical
outcomes.
reliability
signatures
was
assessed
using
receiver
operating
characteristic
(ROC)
survival
analyses
verified
with
external
datasets.
Furthermore,
correlation
between
other
cells
environment,
signature
classifier,
efficacy
immunotherapy
were
also
investigated.
GLY
score
low/TME
high
subgroup
showed
favorable
therapeutic
response
significant
differences
immune-related
molecules
signaling
mechanisms.
We
evaluated
role
demonstrated
overall
significance
for
before
treatment,
which
may
new
options
creating
best
possible
approaches
patients.
Interdisciplinary cancer research,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
The
chapter
examines
and
analyses
scientific
publications
devoted
to
the
role
of
mitochondria
in
support
life
transformed
cells
study
characteristics
structural
functional
dysfunctions
mitochondria.
Issues
mitochondrial
control
cellular
redox
homeostasis
sites
reactive
oxygen
species
(ROS)
production
inner
membrane
are
considered.
features
reorganisation
malignant
tumour
mechanisms
reprogramming
energy
metabolism,
increasing
ROS
production,
adaptation
conditions
hypoxia
metabolic
stress
analysed.
Mitochondrial
dysfunction,
activation
oncogenes,
inactivation
anti-oncogenes,
cell
microenvironment
have
a
profound
effect
on
metabolism
cancer
determine
heterogeneity
profiles
between
different
types.
importance
identifying
specific
changes
each
is
clear
given
need
effectively
influence
its
growth.
Understanding
dysfunction
very
important
for
studying
pathophysiology
many
other
common
diseases.
This
gives
impetus
development
pharmacology
using
as
targets
types
effects,
which
can
serve
biochemical
basis
new
antitumour
agents.
Perhaps
combined
use
modulators
agents
will
contribute
emergence
direction
therapy
that
significantly
increase
effectiveness
treatment
patients.
The
role
of
nutrition
in
shaping
the
immune
system
is
a
critical
aspect
maintaining
overall
health,
particularly
during
vulnerable
periods
like
early
lactation
dairy
cows.
Various
nutrients,
including
glucose,
glutamine
(Gln),
and
ketones,
have
been
found
to
impact
cell
function.
Gln,
versatile
amino
acid,
serves
as
precursor
for
DNA
RNA
synthesis,
NADPH
production,
energy
generation,
all
crucial
responses.
Gln
plays
pivotal
cytokine
synthesis
phagocytosis,
macrophages
monocytes.
Glucose
essential
proliferation,
survival,
differentiation
cells,
with
activated
cells
relying
on
it
their
primary
metabolic
fuel.
Restricting
glucose
uptake
phagocytic
has
shown
impair
function,
which
highlights
importance
availability
when
mounting
an
effective
response.
Ketones,
especially
β-hydroxybutyrate
(BHBA),
associated
compromised
function
Elevated
BHBA
levels
can
hinder
chemotaxis
respiratory
burst
activity
neutrophils,
potentially
increases
risk
infections
mastitis.
Additionally,
may
lymphocyte
proliferation
antibody
secretion
further
compromise
defenses.
Non-esterified
fatty
acids
(NEFAs)
complex
effects
both
stimulatory
inhibitory
observed.
NEFAs
phagocyte
immunoglobulin
(Ig)M
secretion,
production.
type
concentration
circulation
determine
whether
they
enhance
or
suppress
Energy
balance
these
interactions,
negative
(NEB)
exacerbating
immunosuppression.
Epidemiological
studies
linked
metabolites
characteristic
NEB
mastitis
risk,
suggests
that
multiple
blood
serve
better
indicators
than
individual
markers.
Integrative Cancer Therapies,
Год журнала:
2024,
Номер
23
Опубликована: Янв. 1, 2024
The
following
narrative
review
embarks
on
a
comprehensive
exploration
of
the
role
played
by
gut
microbiome
within
Diet-Microbiota-Immunity
(DMI)
tripartite,
aiming
to
enhance
anti-cancer
immunotherapy
efficacy.
While
revolutionizing
cancer
treatment,
resistance
and
immune-related
adverse
events
(irAEs)
remain
challenges.
tumor
microenvironment
(TME),
shaped
cells,
influences
resistance.
microbiome,
influenced
genetics,
environment,
diet,
interventions,
emerges
as
critical
player
in
TME
reshaping,
thereby
modulating
immune
responses
treatment
outcomes.
Dietary
patterns
like
Mediterranean
caloric
restriction
modifications,
specific
nutritional
components
show
promise
influencing
for
better
Antibiotics,
disrupting
microbiota
diversity,
may
compromise
This
emphasizes
need
tailored
strategies
manipulate
microbial
communities,
regulation,
improve
accessibility
while
minimizing
side
effects.
Ongoing
studies
investigate
impact
dietary
interventions
immunotherapy,
pointing
toward
promising
developments
personalized
care.
synthesizes
existing
knowledge
charts
course
future
investigations,
presenting
holistic
perspective
dynamic
interplay
between
DMI
tripartite.
Journal of Cellular Physiology,
Год журнала:
2024,
Номер
240(1)
Опубликована: Сен. 8, 2024
Neoplastic
transformation
reprograms
tumor
and
surrounding
host
cell
metabolism,
increasing
nutrient
consumption
depletion
in
the
microenvironment.
Tumors
uptake
nutrients
from
neighboring
normal
tissues
or
bloodstream
to
meet
energy
anabolic
demands.
Tumor-induced
chronic
inflammation,
a
high-energy
process,
also
consumes
sustain
its
dysfunctional
activities.
These
tumor-related
metabolic
physiological
changes,
including
negatively
impact
systemic
metabolism
physiology.
Furthermore,
adverse
effects
of
antitumor
therapy
obstruction
impair
endocrine,
neural,
gastrointestinal
systems,
thereby
confounding
status
patients.
alterations
result
decreased
appetite,
impaired
absorption,
shift
catabolic
metabolism.
Consequently,
cancer
patients
often
suffer
malnutrition,
which
worsens
prognosis
increases
susceptibility
secondary
events.
This
review
explores
how
neoplastic
affects
microenvironment
leading
poor
prognosis,
discusses
potential
strategies
clinical
interventions
improve
patient
outcomes.
Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Год журнала:
2024,
Номер
unknown, С. 29 - 52
Опубликована: Дек. 17, 2024
Tumor
formation
and
progression
are
caused
by
neoplastic
cells,
which
take
advantage
of
interfere
with
cellular
processes
that
control
growth,
survival,
division.
New
research
emphasizes
the
critical
role
tumor
microenvironment
(TME)
in
cancer
initiation
metastasis,
even
though
genetic
epigenetic
changes
well-known
malignant
transformation.
The
influences
metagenesis,
angiogenesis,
immune
tolerance,
helps
cells
proliferate
rapidly.
It
also
plays
a
origin,
progression,
invasion
cancer.
With
variety
roles,
including
matrix
deposition
remodeling,
extensive
reciprocal
signaling
connections
crosstalk
invading
leukocytes,
cancer-associated
fibroblasts
(CAFs)
an
essential
part
microenvironment.
This
chapter
reveals
origins
CAFs
heterogeneity
CAF
function,
wherein
it
is
preferable
to
preserve
some
antitumorigenic
properties.
