Theranostics in Lung Neuroendocrine Tumors

Seminars in Nuclear Medicine, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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A clinical perspective on ectopic Cushing’s syndrome

Trends in Endocrinology and Metabolism, Год журнала: 2023, Номер 35(4), С. 347 - 360

Опубликована: Дек. 23, 2023

Cushing's syndrome (CS) refers to the clinical features of prolonged pathological glucocorticoid excess. About 10–20% individuals with CS have ectopic (ECS), that is, an adrenocorticotropin (ACTH)-producing tumour outside pituitary gland. ACTH-secreting neuroendocrine neoplasia (NENs) can arise from many organs, although bronchial NEN, small cell lung cancer (SCLC), pancreatic thymic medullary thyroid (MTC), and pheochromocytoma are most common. Patients ECS frequently present severe hypercortisolism. The risk life-threatening complications is high in cases, unless hypercortisolism effectively treated. A good outcome requires a methodical approach, incorporating prompt diagnosis, localization, control cortisol excess, resection primary when possible.

Язык: Английский

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Raising the bar: evaluating quality and consistency in clinical guidelines for surgical management of pulmonary carcinoid

European Journal of Cancer Prevention, Год журнала: 2025, Номер unknown

Опубликована: Янв. 7, 2025

Leading societies have established guidelines that vary significantly regarding recommendations for the surgical management of pulmonary carcinoids (PC). We aimed to assess current and PC management, benchmark their methodological quality, identify factors may influence effectiveness in guiding practice. Literature was sought relevant PC. Each guideline evaluated using Appraisal Guidelines Research Evaluation (AGREE II) tool rated on a seven-point scale items domains. Five observers assessed four (developed by ENETS 2015, ESMO 2021, NANETS NCCN 2020). In Scope Purpose Stakeholder Involvement, achieved highest score. Rigor Development, Clarity Presentation, scored For applicability, received All got score Development Presentation domains, whereas Applicability domain lowest The quality varies significantly. findings underscore need future prioritize practical implementation clinical practice, ensuring reflect best practices effectively meet surgeons’ needs. Based our AGREE II appraisal, might be recommended as model developing guidelines.

Язык: Английский

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Promising Short-Term Outcomes of Pulmonary Resections from Low-Volume Centre in Tier II City in India

Indian Journal of Surgical Oncology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Abstract Lung cancer is one of the leading causes cancer-related deaths in world. Surgery offers best potential cure, but as any surgery, there are some complications that will be minimised with improvement surgical practice and treatment protocols. This study aims to analyse short-term outcomes thoracoscopic open lung resections a low volume centre at Visakhapatnam, India. Twelve patients who underwent or for primary metastatic tumors from September 2022 December 2023 Homi Bhabha Cancer Hospital & Research Centre (HBCH&RC), were analysed retrospectively. Data was collected Electronic Medical Records including demographic data, neo-adjuvant adjuvant therapy, procedure performed, histopathology type, time chest drain removal, length hospital stay, perioperative mortality morbidity occurring within 30 days after surgery. Statistical analysis performed using SPSS version 26. A total 12 pulmonary during period. Median age 48.5 years. Surgical procedures 4-bilobectomies, 7-lobectomies 1-metastasectomy. Chest wall resection 2 cases, pericardial diaphragm excision case. approaches video-assisted surgery (VATS), VATS converted open—4 each. Major common air leak collapse which occurred 33.3% patients. duration stay 6.5 days. There no 30-day mortality. Safe achievable (both procedures) low-volume trained dedicated surgeons, anaesthesiologists proper patient selection.

Язык: Английский

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Development and Evaluation of a Multivariable Prediction Model for Overall Survival in Advanced Stage Pulmonary Carcinoid Using Machine Learning

European Journal of Surgical Oncology, Год журнала: 2025, Номер unknown, С. 109729 - 109729

Опубликована: Фев. 1, 2025

Язык: Английский

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Pathological & radiological variables in the diagnosis of bronchopulmonary carcinoids (BPCs) with a focus on Antigen Kiel 67 (Ki-67) proliferation index

Lung Cancer, Год журнала: 2025, Номер 202, С. 108493 - 108493

Опубликована: Март 11, 2025

Язык: Английский

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Endocrine paraneoplastic syndromes in lung cancer: A call for clinical vigilance (Review)

Molecular and Clinical Oncology, Год журнала: 2025, Номер 22(4), С. 1 - 10

Опубликована: Март 5, 2025

Endocrine paraneoplastic syndromes (PNS) are uncommon but clinically impactful manifestations associated with malignancies, particularly lung cancer, most notably small-cell cancer. These arise from ectopic hormone production by malignant cells, causing systemic effects that independent of direct tumor invasion or metastasis. Their presentation often precedes signals recurrence the primary underscoring importance early recognition and targeted intervention. Common endocrine PNS in cancer include syndrome inappropriate antidiuretic secretion, hypercalcemia, Cushing syndrome, carcinoid other hormonal imbalances such as non-islet cell hypoglycemia, gynecomastia acromegaly. The pathophysiology these conditions involves secretion bioactive substances hormones cytokines, leading to diverse clinical manifestations. Accurate diagnosis necessitates a combination biochemical assessments, imaging modalities, histopathological evaluations differentiate processes disorders. Management strategies emphasize treating underlying malignancy, through chemotherapy, radiotherapy, surgical intervention, alongside symptomatic therapies tailored specific abnormality. Multidisciplinary care is critical for optimizing outcomes enhancing patients' quality life. current review highlights need heightened vigilance systematic approach diagnosing managing By fostering detection comprehensive management, clinicians can significantly improve prognostic affected individuals.

Язык: Английский

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ANALYSIS OF THE OUTCOMES OF SURGICAL TREATMENT IN PATIENTS WITH BRONCHOPULMONARY CARCINOID TUMORS

Clinical and Preventive Medicine, Год журнала: 2025, Номер 1, С. 65 - 71

Опубликована: Янв. 20, 2025

Inroduction. Surgical resection of bronchopulmonary carcinoid tumors remains the primary treatment modality and provides good outcomes. There exists debate, however, about optimal extent for this disease. Lung-sparing bronchial sleeve resections have been priority approach in past decades. Aim. Statistical analysis to determine long-term outcomes different surgical approaches was conducted. Materials methods. From 2005 through 2022, 124 patients who underwent pulmonary were reviewed. Results processed using mathematical statistics (descriptive statistics, exploratory data analysis, Student's correlation t-test, chi quadrant test Kaplan-Meier analysis) IBM SPSS v23 statistical package. Results. from 2022. All received complete their tumors, with 32,3% (40/124) undergoing isolated resection, 4,0% (5/124) parenchyma-sparing resection. In case peripheral 15,3% (19/124) sublobar 4,8% (6/124) lobectomy 0,8% (1/124) segmentectomy. no peri-operative mortalities. Median follow-up 1949 days. Overall 5- 10-year survival 75,1 % 73,4 respectively. typical atypical 69,3 73,2 When comparing lobar according function, t test, Spearman's correlation, risk metastases tumor recurrence does not depend on type surgery that performed. Conclusions. Excellent can be achieved following tumors. central localization, there is significant difference or recurrence. The decreases over time, regardless

Язык: Английский

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Absence of orthopaedia homeobox protein (OTP) expression is associated with disease spread and adverse outcome in pulmonary carcinoid tumour patients

Virchows Archiv, Год журнала: 2024, Номер unknown

Опубликована: Июнь 19, 2024

Abstract Pulmonary carcinoid (PC) tumours typically have a good prognosis, although metastases occur, and the disease may progress after long period of time. Expression orthopaedia homeobox protein (OTP) has been recognized as possible independent prognostic marker in PCs. Immunohistochemical (IHC) OTP expression associated with better but staining yet to be implemented routine clinical diagnostics. In response this, two new monoclonal antibodies were recently developed. This retrospective study included 164 PC patients operated on at Helsinki University Hospital between 1990 2020. Tissue microarray slides, prepared from formalin-fixed paraffin-embedded primary tumour samples, stained IHC using one polyclonal novel antibodies. Absence was shorter disease-specific survival (DSS) progression ( p < 0.001). Patients without had 5-year DSS 73–79%, whereas 91–94% expression, depending antibody. univariable Cox regression model, absence adverse outcome along atypical histological subtype, metastatic disease, Ki-67 proliferation index > 1%, larger size. multivariable only lymph node involvement time diagnosis risk worse prognosis. All three showed concordance each other. Our findings support role an PCs applicability use

Язык: Английский

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Perioperative Management of a Patient With Multiple Comorbidities Undergoing Lung Resection for Bronchopulmonary Carcinoid Complicated by SARS-CoV-2 Infection: A Case Report

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Апрель 15, 2024

We report a case of high-risk patient with multiple comorbidities who underwent right median lobectomy and lymph node resection due to carcinoid tumor. The patient's course was complicated by hospital-acquired severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection postoperative chest hematoma requiring urgent thoracotomy. Multidisciplinary timely management resulted in favorable outcome.

Язык: Английский

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