Baicalein, a natural flavonoid in gastrointestinal cancers treatment: recent trends and future perspectives DOI
Añil Sharma, Deeksha Pal,

Anita Rani Gill

и другие.

Medical Oncology, Год журнала: 2024, Номер 42(1)

Опубликована: Дек. 24, 2024

Язык: Английский

Mapping the knowledge domains of literature on hepatocellular carcinoma and liver failure: a bibliometric approach DOI Creative Commons
Jun Pu,

Zhao Ya-min,

Siming Zhang

и другие.

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Апрель 16, 2025

Hepatocellular carcinoma (HCC) accounts for 75-85% of primary liver cancers, with its incidence continually rising, posing a threat to socio-economic development. Currently, resection is the standard treatment HCC. However, post-hepatectomy failure (PHLF) severe and formidable postoperative complication that increases patients' medical expenses mortality risk. Additionally, can occur at any stage HCC development, severely affecting quality life prognosis. Using Web Science Core Collection, this bibliometric study analyzed English articles reviews on from 2003 2023. Bibliometric tools like CiteSpace, VOSviewer, R-studio were employed data visualization analysis, focusing publication trends, citation metrics, explosive intensity, collaborative networks. Use Comparative Toxicogenomics Genecards databases screen genes related failure, perform enrichment analyses using Gene Ontology, Kyoto Encyclopedia Genes Genomes, PubMed identified differentially expressed genes. The significant increase in publications key contributions journals such as World Journal Gastroenterology Hepatology. United States, China, Japan leading countries research output. Prominent authors institutions, including Kudo Masatoshi Sun Yat-sen University, identified. Enrichment analysis showed drug metabolism, oxidative stress, lipid other pathways are closely field. Research hotspots included risk prediction models novel therapies. This highlights growing interest advancements failure. Future should focus improving prediction, developing new therapies, enhancing international collaboration address these critical health issues.

Язык: Английский

Процитировано

0
Recent advancements in the small-molecule drugs for hepatocellular carcinoma (HCC): Structure-activity relationships, pharmacological activities, and the clinical trials DOI Open Access

Qichuan Deng,

Yü Huang, Jing Zeng

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 179, С. 117343 - 117343

Опубликована: Авг. 24, 2024

BACKGROUND AND AIMS: Hepatocellular carcinoma (HCC) is one of the most common malignancies in world and sixth leading cause cancer death worldwide, it urgent to find safe effective drugs for treatment. As an important therapeutic method, small-molecule are continually being updated achieve improved effects. The purpose this study was investigate structural effects various FDA-listed sorafenib, cabozantinib, lenvatinib, regorafenib on corresponding HCC targets possible optimization methods, explore mechanism identifying potential that offer better efficacy fewer side

Язык: Английский

Процитировано

3
The role of inflammasomes in hepatocellular carcinoma: Mechanisms and therapeutic insights DOI Creative Commons

Valentina Arrè,

Roberto Negro, Gianluigi Giannelli

и другие.

Annals of Hepatology, Год журнала: 2024, Номер unknown, С. 101772 - 101772

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

0
Baicalein, a natural flavonoid in gastrointestinal cancers treatment: recent trends and future perspectives DOI
Añil Sharma, Deeksha Pal,

Anita Rani Gill

и другие.

Medical Oncology, Год журнала: 2024, Номер 42(1)

Опубликована: Дек. 24, 2024

Язык: Английский

Процитировано

0