Curcumin nanoparticles alleviate brain mitochondrial dysfunction and cellular senescence in γ-irradiated rats

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 31, 2025

Despite the diverse applications of γ radiation in radiotherapy, industrial processes, and sterilization, it causes hazardous effects on living organisms, such as cellular senescence, persistent cell cycle arrest, mitochondrial dysfunction. This study evaluated efficacy curcumin nanoparticles (CNPs) mitigating dysfunction senescence induced by rat brain tissues. Four groups male Wistar albino rats (n = 8 per group) were included: (Gr1) control group; (Gr2) CNPs group (healthy receiving oral administration at a dose 10 mg/kg/day, three times week for eight weeks); (Gr3) irradiated (rats exposed to single Gy head irradiation); (Gr4) + (irradiated treated with CNPs). The data obtained demonstrated that weeks attenuated oxidative stress γ-irradiated lowering brain's lipid peroxidation level [malondialdehyde (MDA)] enhancing antioxidant markers [superoxide dismutase (SOD), reduced glutathione (GSH), total capacity (TAC)] (P < 0.05). In addition, significantly increased function improving complex I, II, ATP production levels compared group. rats, also showed anti-neuroinflammatory reducing interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α), nuclear factor-kappa B (NF-ĸB) Moreover, administered β-galactosidase activity expression p53, p21, p16 genes 0.05) while concurrently inducing significant increase AMPK mRNA conclusion, ameliorated neurotoxicity hold promise novel agent delay via their combined antioxidant, anti-inflammatory, mitochondrial-enhancing properties.

Язык: Английский

---

Phytochemicals in Breast Cancer Prevention and Treatment: A Comprehensive Review

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(1), С. 30 - 30

Опубликована: Янв. 6, 2025

Extensive investigation has been conducted on plant-based resources for their pharmacological usefulness, including various cancer types. The scope of this review is wider than several studies with a particular focus breast cancer, which an international health concern while studying sources flavonoids, carotenoids, polyphenols, saponins, phenolic compounds, terpenoids, and glycosides apart from focusing nursing. Important findings prior are synthesized to explore these compounds' sources, mechanisms action, complementary synergistic effects, associated side effects. It was reviewed that the exposure certain doses catechins, piperlongumine, lycopene, isoflavones cucurbitacinfor sufficient period can provide profound anticancer benefits through biological events such as cell cycle arrest, cells undergoing apoptosis disruption signaling pathways including, but not limited JAK-STAT3, HER2-integrin, MAPK. Besides, study also covers potential adverse effects phytochemicals. Regarding mechanisms, widest attention paid Complementary strategies discussed indicate it would be realistic alter dosage delivery systems liposomes, nanoparticles, nanoemulsions, films enhance efficacy. Future research directions include refining approaches, further elucidating molecular conducting clinical trials validate findings. These efforts could significantly advance role phytocompounds in management.

Язык: Английский

---

Targeting the Hippo and Rap1 signaling pathways: the anti-proliferative effects of curcumin in colorectal cancer cell lines

Medical Oncology, Год журнала: 2025, Номер 42(2)

Опубликована: Янв. 8, 2025

Язык: Английский

---

Curcumin-Based Nanoparticles: Advancements and Challenges in Tumor Therapy

Pharmaceutics, Год журнала: 2025, Номер 17(1), С. 114 - 114

Опубликована: Янв. 15, 2025

Curcumin, a bioactive compound derived from the rhizome of Curcuma longa L., has garnered significant attention for its potent anticancer properties. Despite promising therapeutic potential, poor bioavailability, rapid metabolism, and low water solubility hinder curcumin’s clinical application. Nanotechnology offers viable solution to these challenges by enabling development curcumin-based nanoparticles (CNPs) that enhance bioavailability efficacy. This review provides comprehensive overview recent advancements in design synthesis CNPs cancer therapy. We discuss various NP formulations, including polymeric, lipid-based, inorganic nanoparticles, highlighting their role improving pharmacokinetic pharmacodynamic profiles. The mechanisms which exert effects, such as inducing apoptosis, inhibiting cell proliferation, modulating signaling pathways, are explored details. Furthermore, we examine preclinical studies have demonstrated efficacy treating different types tumors, breast, colorectal, pancreatic cancers. Finally, addresses current future perspectives translation CNPs, emphasizing need further research optimize targeted delivery outcomes. By synthesizing latest research, this underscores potential avenue advancing

Язык: Английский

---

Fmoc-FF Nanogel-Mediated Delivery of Doxorubicin and Curcumin in Thyroid Cancer Cells

Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 263 - 263

Опубликована: Фев. 17, 2025

Background: Thyroid cancer (TC) is the most prevalent endocrine malignancy, and categorized into well-differentiated aggressive anaplastic types. Novel therapeutic modalities are needed for TC. Nanomedicine a promising strategy development of precision medicine. In this context, we investigated use nanogels (NGs) to deliver agents with different physicochemical properties, specifically hydrophilic agent doxorubicin (DOX) hydrophobic compound curcumin (CUR), in TC cell lines. Methods: Nα-9-fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) peptide-based NGs loaded DOX CUR were formulated using solvent-switch method. DOX-loaded previously characterized. CUR-loaded characterized through rheology, scanning electron microscopy (SEM), dynamic light scattering (DLS), nanoparticle tracking analysis (NTA), Fourier transform infrared (FT-IR) spectroscopy. Confocal microscopy, q-RT-PCR, ATP lite assays performed evaluate uptake delivery DOX- on Results: exhibited mean diameter approximately 204.3 nm zeta potential -34.6 mV, indicative good stability. vitro release studies revealed sustained profile over 72 h. Functional analyses demonstrated that Fmoc-FF-loaded internalized They primarily localized cytoplasm rather than early endosomes, thereby ensuring intracellular Furthermore, Fmoc-FF reduced nuclear kinetics cells, suggesting reduction dose-limiting toxicity. Comparative similar internalization delayed uptake, highlighting efficacy delivering agents. Conclusions: Overall, data suggest represent diverse properties TC, enhancing their safety warranting further investigation.

Язык: Английский

---

The Bright Side of Curcumin: A Narrative Review of Its Therapeutic Potential in Cancer Management

Cancers, Год журнала: 2024, Номер 16(14), С. 2580 - 2580

Опубликована: Июль 18, 2024

Curcumin, a polyphenolic compound derived from Curcuma longa, exhibits significant therapeutic potential in cancer management. This review explores curcumin’s mechanisms of action, the challenges related to its bioavailability, and enhancement through modern technology approaches. Curcumin demonstrates strong antioxidant anti-inflammatory properties, contributing ability neutralize free radicals inhibit inflammatory mediators. Its anticancer effects are mediated by inducing apoptosis, inhibiting cell proliferation, interfering with tumor growth pathways various colon, pancreatic, breast cancers. However, clinical application is limited poor bioavailability due rapid metabolism low absorption. Novel delivery systems, such as curcumin-loaded hydrogels nanoparticles, have shown promise improving curcumin efficacy. Additionally, photodynamic therapy has emerged complementary approach, where light exposure enhances modulating molecular crucial for survival. Studies highlight that combining concentrations visible irradiation significantly boosts antitumor efficacy compared alone. The interaction cytochromes or drug transporters may play role altering pharmacokinetics conventional medications, which necessitates careful consideration settings. Future research should focus on optimizing understanding fully harness treatment.

Язык: Английский

---

Harnessing nature's therapeutic potential: A review of natural products in prostate cancer management

Urologic Oncology Seminars and Original Investigations, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

---

Unravelling the epigenetic based mechanism in discovery of anticancer phytomedicine: Evidence based studies

Cellular Signalling, Год журнала: 2025, Номер unknown, С. 111743 - 111743

Опубликована: Март 1, 2025

Язык: Английский

---

Nanoparticle-Based Delivery Systems for Phytochemicals in Cancer Therapy: Molecular Mechanisms, Clinical Evidence, and Emerging Trends

Drug Development and Industrial Pharmacy, Год журнала: 2025, Номер unknown, С. 1 - 31

Опубликована: Март 21, 2025

This review examines recent advancements in nanoparticle-based delivery systems for phytochemicals, focusing on their role overcoming multidrug resistance, improving therapeutic efficacy, and facilitating clinical translation. highlights advances nanoparticle-enabled phytochemical to enhance bioavailability, improve outcomes, enable targeted applications. By comparing various nanoparticle systems, formulation methods, efficacy data, it identifies gaps current research guides the development of more effective, next-generation phytochemical-loaded nanocarriers. A systematic literature published between 2000 2024 was conducted using PubMed, Scopus, Web Science. Articles cancer therapy were included. Compounds such as curcumin, resveratrol, quercetin, epigallocatechin gallate demonstrate enhanced anti-cancer when encapsulated nanoparticles, leading improved increased tumor cell targeting, reduced toxicity. Clinical trials indicate regression fewer adverse effects. Emerging approaches-such nanogels, hybrid combination therapies with immune checkpoint inhibitors-further refine treatment efficacy. Nanoparticle-based significantly potential making them promising candidates safer, effective treatments. However, challenges related regulatory guidelines, scalability, long-term safety must be addressed fully realize potential.

Язык: Английский

---

In Silico Discovery of a Novel Natural Product Targeting PI3Kα for the Treatment of Head and Neck Squamous Cell Carcinoma

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(8), С. 3565 - 3565

Опубликована: Апрель 10, 2025

Head and neck squamous cell carcinoma (HNSCC) remains a major health burden, with abnormal activation of phosphatidylinositol 3-kinase alpha (PI3Kα) strongly implicated in its pathogenesis. Targeting PI3Kα represents promising therapeutic strategy. In this study, we employed structure-based virtual screening to identify natural small-molecule inhibitors PI3Kα. A total 12,800 molecules were screened, five compounds selected for further evaluation based on binding affinity interaction patterns. Pharmacokinetic properties assessed using ADMET predictions, molecular dynamics (MD) simulations conducted validate the stability. Among candidates, Apigetrin demonstrated favorable properties, high safety profile, stable within ATP-binding pocket These findings suggest that is inhibitor potential relevance HNSCC.

Язык: Английский

---