Hyaluronic acid-functionalized nanomedicines for CD44-receptors-mediated targeted cancer therapy: A review of selective targetability and biodistribution to tumor microenvironment

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142486 - 142486

Опубликована: Март 1, 2025

Язык: Английский

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Chitosan Approaches in Colon Cancer Therapy: Understanding its Macromolecular Interactions and Structure-Property Relationships

Journal of Macromolecular Science Part B, Год журнала: 2025, Номер unknown, С. 1 - 12

Опубликована: Янв. 9, 2025

Colon cancer is still a significant cause of cancer-related deaths and, therefore, new treatment approaches are required. As naturally derived polysaccharide, Chitosan has become one the most promising materials in polymer-based drug delivery systems because its outstanding biocompatibility, biodegradability, and pH-responsive release. This review explores expanding roles chemical modifications colon therapy, emphasizing relationship between macromolecular interactions structure-property dynamics. Recent progress Chitosan-based nanocarriers, including nanoparticles, nanogels hybrid systems, highlights their potential to overcome multidrug resistance minimize off-target toxicity. These advancements closely aligned with developments precision medicine, incorporating stimuli-responsive components targeted ligands for enhanced efficacy. While preclinical clinical studies yield results, critical challenges such as scalability, reproducibility regulatory compliance remain obstacles translation. emphasizes transformative addressing therapeutic barriers treatment. Looking ahead, future should focus on utilizing cutting-edge technologies, artificial intelligence 3D bioprinting, enhance formulations develop personalized solutions that more effective tailored individual needs.

Язык: Английский

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ALDH1A1 as a marker for metastasis initiating cells: a mechanistic insight

Experimental Cell Research, Год журнала: 2024, Номер 442(1), С. 114213 - 114213

Опубликована: Авг. 22, 2024

Язык: Английский

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Elucidating a Tumor‐Selective Nanoparticle Delivery Mechanism at the Colorectal Lumen–Tumor Interface for Precise Local Cancer Therapy

Small, Год журнала: 2025, Номер unknown

Опубликована: Янв. 19, 2025

Abstract Although various colorectal cancer (CRC)‐targeted nanoparticles have been developed to selectively deliver anticancer agents tumor tissues, severe off‐target side effects still persist due unwanted systemic nanoparticle distribution, limiting the therapeutic outcome. Here, by elucidating a tumor‐selective delivery mechanism occurring at lumen–tumor interface, an alternative CRC‐targeted route is proposed, which enables highly without through direct drug from outside of body (colorectal lumen) tumors in colorectum. Owing presence accessible tumor‐specific receptors such as CD44 but not lumen–normal tissue luminal surface (CLS)‐targeting ligand‐functionalized accumulate CRC tissues resulting successful local therapy. The findings suggest that CLS‐targeted lumen‐to‐tumor can be suitable strategy for CRC‐specific precise

Язык: Английский

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Gene Expression Profiling Identifies CAV1, CD44, and TFRC as Potential Diagnostic Markers and Therapeutic Targets for Multiple Myeloma

Cell Biochemistry and Biophysics, Год журнала: 2025, Номер unknown

Опубликована: Апрель 17, 2025

Язык: Английский

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Design strategies for hyaluronic acid-based drug delivery systems in cancer immunotherapy

Journal of Controlled Release, Год журнала: 2025, Номер 383, С. 113784 - 113784

Опубликована: Апрель 26, 2025

Язык: Английский

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The use of hyaluronic acid in a 3D biomimetic scaffold supports spheroid formation and the culture of cancer stem cells

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Авг. 22, 2024

Three-dimensional (3D) bioprinting culture models capable of reproducing the pathological architecture diseases are increasingly advancing. In this study, 3D scaffolds were created using extrusion-based method with alginate, gelatin, and hyaluronic acid to investigate effects on physical properties bioscaffold as well formation liver cancer spheroids. Conformational analysis, rheological characterization, swelling-degradation tests performed characterize scaffolds. After generating spheroids from hepatocellular carcinoma cells scaffolds, cell viability proliferation assays performed. Flow cytometry immunofluorescence microscopy used into examine expression albumin, CD44, E-cadherin demonstrate functional capability maturation levels spheroid-forming cells. The results show that in correlates spheroid provides high survival rates. It is also associated an increase CD44 a decrease E-cadherin, while there no significant change albumin Overall, findings hydrogel scaffold supports may induce stemness. We present promising model for enhancing mimicking solid tumors. This has potential further studies stem models.

Язык: Английский

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Signalling and molecular pathways, overexpressed receptors of colorectal cancer and effective therapeutic targeting using biogenic silver nanoparticles

Gene, Год журнала: 2024, Номер unknown, С. 149099 - 149099

Опубликована: Ноя. 1, 2024

Язык: Английский

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