ECD, a novel androgen receptor target promotes prostate cancer tumorigenesis by regulating glycolysis
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Abstract
Androgen
receptor
(AR)-mediated
signaling
is
essential
for
PC
tumorigenesis.
In
TCGA
database
we
observed
a
positive
correlation
between
ECD
and
AR
expression.
Consistently,
Dihydrotestosterone
(DHT)
treatment
of
cell
lines
increased
mRNA
protein
levels,
knockdown
(KD)
reduced
Bioinformatic
analysis
predicted
three
consensus
androgen
response
elements
in
the
promoter,
DHT
occupancy
at
enhanced
promoter
activity.
Enzalutamide
decreased
knockout
(KO)
cells
oncogenic
traits,
suggesting
functional
role
to
maintain
oncogenesis.
are
overexpressed
patient
tissues,
its
overexpression
predicts
shorter
survival.
Overexpression
traits
vitro
developed
faster
larger
highly
proliferative
xenograft
tumors.
RNA-seq
mouse
tumors
revealed
increase
levels
several
glycolytic
genes.
associates
with
key
genes
required
their
stability,
consistent
our
recent
demonstration
as
an
RNA
binding
protein.
Higher
glucose
uptake
glycolysis
was
seen
upon
OE
cells.
Together,
demonstrate
novel
target
gene
Язык: Английский
DLGAP5 upregulates E2F1 to promote prostate adenocarcinoma neuroendocrine differentiation
Life Sciences,
Год журнала:
2025,
Номер
unknown, С. 123442 - 123442
Опубликована: Фев. 1, 2025
Язык: Английский
Cell Progression and Survival Functions of Enzymes Secreted in Extracellular Vesicles Associated with Breast and Prostate Cancers
Cells,
Год журнала:
2025,
Номер
14(7), С. 468 - 468
Опубликована: Март 21, 2025
Extracellular
vesicles
(EVs)
are
membrane-bound
cargoes
secreted
by
normal
and
pathological
cells.
Through
their
protein,
nucleic
acid,
lipid
cargoes,
EVs
mediate
several
cellular
processes,
such
as
cell–cell
communication,
cell
development,
immune
response,
tissue
repair.
Most
importantly,
through
enzyme
cargo,
pathophysiological
including
the
pathogenesis
of
cancer.
In
this
review,
we
enumerate
enzymes
in
(EV
cargo)
from
cells
patient
clinical
samples
breast
prostate
cancers
detail
contributions
to
progression
survival
both
cancers.
Findings
review
reveal
that
EV
cargo
could
exert
functions
via
adhesion,
proliferation,
migration,
invasion,
metastasis.
The
might
also
influence
chemoresistance,
radioresistance,
angiogenesis,
death
inhibition,
colony
formation,
evasion.
While
current
literature
provides
evidence
possible
mechanisms
cancers,
future
studies
required
validate
these
effects
modified
provide
insights
into
applications
Язык: Английский